Oxime Esters of 2,6-Diazaanthracene-9,10-dione and 4,5-Diazafluoren-9-one as Photo-induced DNA-Cleaving Agents
Two series of oxime esters containing the 2,6-diazaanthracene-9,10-dione bis-(O-benzoyloxime) and 4,5-diazafluoren-9-one O-9-benzoyloxime moieties have been synthesized and tested as photo-induced DNA cleaving agents. All these compounds were found to cleave DNA upon irradiation with 312 nm UV light...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2012-03-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/17/3/3370/ |
| _version_ | 1819210778654277632 |
|---|---|
| author | Shang-Shing P. Chou Jui-Chi Juan Shwu-Chen Tsay Kuei Pin Huang Jih Ru Hwu |
| author_facet | Shang-Shing P. Chou Jui-Chi Juan Shwu-Chen Tsay Kuei Pin Huang Jih Ru Hwu |
| author_sort | Shang-Shing P. Chou |
| collection | DOAJ |
| description | Two series of oxime esters containing the 2,6-diazaanthracene-9,10-dione bis-(O-benzoyloxime) and 4,5-diazafluoren-9-one O-9-benzoyloxime moieties have been synthesized and tested as photo-induced DNA cleaving agents. All these compounds were found to cleave DNA upon irradiation with 312 nm UV light. The structure-activity relationship of these molecules for DNA cleavage was established. A plausible reaction mechanism is also proposed. |
| first_indexed | 2024-12-23T06:16:35Z |
| format | Article |
| id | doaj.art-bd47bf80642c4230817baf412c5a8014 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-23T06:16:35Z |
| publishDate | 2012-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-bd47bf80642c4230817baf412c5a80142022-12-21T17:57:17ZengMDPI AGMolecules1420-30492012-03-011733370338210.3390/molecules17033370Oxime Esters of 2,6-Diazaanthracene-9,10-dione and 4,5-Diazafluoren-9-one as Photo-induced DNA-Cleaving AgentsShang-Shing P. ChouJui-Chi JuanShwu-Chen TsayKuei Pin HuangJih Ru HwuTwo series of oxime esters containing the 2,6-diazaanthracene-9,10-dione bis-(O-benzoyloxime) and 4,5-diazafluoren-9-one O-9-benzoyloxime moieties have been synthesized and tested as photo-induced DNA cleaving agents. All these compounds were found to cleave DNA upon irradiation with 312 nm UV light. The structure-activity relationship of these molecules for DNA cleavage was established. A plausible reaction mechanism is also proposed.http://www.mdpi.com/1420-3049/17/3/3370/photo-induced DNA-cleavageoxime esters2,6-diazaanthracene-9,10-dione4,5-diazafluoren-9-one |
| spellingShingle | Shang-Shing P. Chou Jui-Chi Juan Shwu-Chen Tsay Kuei Pin Huang Jih Ru Hwu Oxime Esters of 2,6-Diazaanthracene-9,10-dione and 4,5-Diazafluoren-9-one as Photo-induced DNA-Cleaving Agents Molecules photo-induced DNA-cleavage oxime esters 2,6-diazaanthracene-9,10-dione 4,5-diazafluoren-9-one |
| title | Oxime Esters of 2,6-Diazaanthracene-9,10-dione and 4,5-Diazafluoren-9-one as Photo-induced DNA-Cleaving Agents |
| title_full | Oxime Esters of 2,6-Diazaanthracene-9,10-dione and 4,5-Diazafluoren-9-one as Photo-induced DNA-Cleaving Agents |
| title_fullStr | Oxime Esters of 2,6-Diazaanthracene-9,10-dione and 4,5-Diazafluoren-9-one as Photo-induced DNA-Cleaving Agents |
| title_full_unstemmed | Oxime Esters of 2,6-Diazaanthracene-9,10-dione and 4,5-Diazafluoren-9-one as Photo-induced DNA-Cleaving Agents |
| title_short | Oxime Esters of 2,6-Diazaanthracene-9,10-dione and 4,5-Diazafluoren-9-one as Photo-induced DNA-Cleaving Agents |
| title_sort | oxime esters of 2 6 diazaanthracene 9 10 dione and 4 5 diazafluoren 9 one as photo induced dna cleaving agents |
| topic | photo-induced DNA-cleavage oxime esters 2,6-diazaanthracene-9,10-dione 4,5-diazafluoren-9-one |
| url | http://www.mdpi.com/1420-3049/17/3/3370/ |
| work_keys_str_mv | AT shangshingpchou oximeestersof26diazaanthracene910dioneand45diazafluoren9oneasphotoinduceddnacleavingagents AT juichijuan oximeestersof26diazaanthracene910dioneand45diazafluoren9oneasphotoinduceddnacleavingagents AT shwuchentsay oximeestersof26diazaanthracene910dioneand45diazafluoren9oneasphotoinduceddnacleavingagents AT kueipinhuang oximeestersof26diazaanthracene910dioneand45diazafluoren9oneasphotoinduceddnacleavingagents AT jihruhwu oximeestersof26diazaanthracene910dioneand45diazafluoren9oneasphotoinduceddnacleavingagents |