Heterozygous mutations in factor H aggravate pathological damage in a stable IgA deposition model induced by Lactobacillus casei cell wall extract

Heterozygous mutations in factor H aggravate pathological damage in a stable IgA deposition model induced by Lactobacillus casei cell wall extract

IntroductionActivation of complement through the alternative pathway (AP) has a key role in the pathogenesis of IgA nephropathy (IgAN). We previously showed, by intraperitoneal injection of Lactobacillus casei cell wall extract (LCWE), C57BL/6 mice develop mild kidney damage in association with glom...

Full description

Bibliographic Details
Main Authors: Jingyi Li, Yaping Dong, Feifei Chen, Hongyu Yang, Pei Chen, Hongyu Li, Sufang Shi, Xujie Zhou, Li Zhu, Yuemiao Zhang, Lijun Liu, Xinfang Xie, Feng Yu, Jing Jin, Jicheng Lv, Hong Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
IgA nephropathy
complement factor H
mouse model
the alternative complement pathway
proteinuria
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1368322/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1368322/full

Similar Items