Influence of ω-3 polyunsaturated fatty acids on oxidative stress and cytochrome P450 2E1 expression in rat liver
Polyunsaturated fatty acids (PUFAs), ω-3 ones in particular, form phospholipid layer of biological membranes, which provides normal functioning of membrane-associated complexes of enzymes and transmembrane transport. Free ω-3 PUFAs regulate the transcription of many genes, and thereby have an effect...
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| Format: | Article |
| Language: | English |
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National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2014-08-01
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| Series: | The Ukrainian Biochemical Journal |
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| _version_ | 1797641775238610944 |
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| author | O. V. Maksymchuk |
| author_facet | O. V. Maksymchuk |
| author_sort | O. V. Maksymchuk |
| collection | DOAJ |
| description | Polyunsaturated fatty acids (PUFAs), ω-3 ones in particular, form phospholipid layer of biological membranes, which provides normal functioning of membrane-associated complexes of enzymes and transmembrane transport. Free ω-3 PUFAs regulate the transcription of many genes, and thereby have an effect on the level of metabolic processes, particularly control of lipid and carbohydrate metabolism in the liver. Cytochrome P450 2E1 (1.14.14.1) causes the transformation of lipophilic exogenous and endogenous substances, as well as involvement in homeostasis, both at the cellular and systemic levels. The aim is to study changes in expression of cytochrome P450 2E1, and to assess the antioxidant system and the level of peroxidation processes in the liver of experimental animals under the chronic action of ω-3 PUFAs. During experiment more than two-fold increase in the content of cytochrome P450 2E1 was observed in the liver of rats which additionally received ω-3 PUFAs for 4 weeks in the standard daily diet. At the same time, such changes in the enzyme expression did not lead to an imbalance of pro- and antioxidant processes in the liver |
| first_indexed | 2024-03-11T13:50:30Z |
| format | Article |
| id | doaj.art-bd4908725a9f4a3594632cb9710188bd |
| institution | Directory Open Access Journal |
| issn | 2409-4943 2413-5003 |
| language | English |
| last_indexed | 2024-03-11T13:50:30Z |
| publishDate | 2014-08-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | The Ukrainian Biochemical Journal |
| spelling | doaj.art-bd4908725a9f4a3594632cb9710188bd2023-11-02T09:08:07ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryThe Ukrainian Biochemical Journal2409-49432413-50032014-08-0186413213710.15407/ubj86.04.132Influence of ω-3 polyunsaturated fatty acids on oxidative stress and cytochrome P450 2E1 expression in rat liverO. V. Maksymchuk0Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, KyivPolyunsaturated fatty acids (PUFAs), ω-3 ones in particular, form phospholipid layer of biological membranes, which provides normal functioning of membrane-associated complexes of enzymes and transmembrane transport. Free ω-3 PUFAs regulate the transcription of many genes, and thereby have an effect on the level of metabolic processes, particularly control of lipid and carbohydrate metabolism in the liver. Cytochrome P450 2E1 (1.14.14.1) causes the transformation of lipophilic exogenous and endogenous substances, as well as involvement in homeostasis, both at the cellular and systemic levels. The aim is to study changes in expression of cytochrome P450 2E1, and to assess the antioxidant system and the level of peroxidation processes in the liver of experimental animals under the chronic action of ω-3 PUFAs. During experiment more than two-fold increase in the content of cytochrome P450 2E1 was observed in the liver of rats which additionally received ω-3 PUFAs for 4 weeks in the standard daily diet. At the same time, such changes in the enzyme expression did not lead to an imbalance of pro- and antioxidant processes in the livercatalasecytochrome P450 2E1malondialdehydesuperoxide dismutaseω-3 polyunsaturated fatty acids |
| spellingShingle | O. V. Maksymchuk Influence of ω-3 polyunsaturated fatty acids on oxidative stress and cytochrome P450 2E1 expression in rat liver The Ukrainian Biochemical Journal catalase cytochrome P450 2E1 malondialdehyde superoxide dismutase ω-3 polyunsaturated fatty acids |
| title | Influence of ω-3 polyunsaturated fatty acids on oxidative stress and cytochrome P450 2E1 expression in rat liver |
| title_full | Influence of ω-3 polyunsaturated fatty acids on oxidative stress and cytochrome P450 2E1 expression in rat liver |
| title_fullStr | Influence of ω-3 polyunsaturated fatty acids on oxidative stress and cytochrome P450 2E1 expression in rat liver |
| title_full_unstemmed | Influence of ω-3 polyunsaturated fatty acids on oxidative stress and cytochrome P450 2E1 expression in rat liver |
| title_short | Influence of ω-3 polyunsaturated fatty acids on oxidative stress and cytochrome P450 2E1 expression in rat liver |
| title_sort | influence of ω 3 polyunsaturated fatty acids on oxidative stress and cytochrome p450 2e1 expression in rat liver |
| topic | catalase cytochrome P450 2E1 malondialdehyde superoxide dismutase ω-3 polyunsaturated fatty acids |
| work_keys_str_mv | AT ovmaksymchuk influenceofō3polyunsaturatedfattyacidsonoxidativestressandcytochromep4502e1expressioninratliver |