Macrophages in bacterial lung diseases: phenotype and functions (review)
This literature review is devoted to the analysis of the role of macrophages in the immunopathogenesis of infectious lung diseases of bacterial etiology. The article summarizes information about the origin of macrophages, their phenotypic and functional heterogeneity. The mechanisms of impaired prot...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2019-05-01
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| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/2178 |
| _version_ | 1797872848190046208 |
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| author | E. G. Churina A. V. Sitnikova O. I. Urazova S. P. Chumakova M. V. Vins A. E. Beresneva V. V. Novitskii |
| author_facet | E. G. Churina A. V. Sitnikova O. I. Urazova S. P. Chumakova M. V. Vins A. E. Beresneva V. V. Novitskii |
| author_sort | E. G. Churina |
| collection | DOAJ |
| description | This literature review is devoted to the analysis of the role of macrophages in the immunopathogenesis of infectious lung diseases of bacterial etiology. The article summarizes information about the origin of macrophages, their phenotypic and functional heterogeneity. The mechanisms of impaired protective function of innate immunity are associated with the polarization of the program of maturation and activation of macrophages in the direction to tolerogenic or immunoregulatory cells with phenotype of M2. Alveolar macrophages perform a variety of functions (from pro-inflammatory to regenerative) in the development of inflammation in the respiratory organs. Their inherent plasticity suggests that the same macrophages can change their phenotype and function depending on the microenvironment in the inflammatory focus at different stages of the disease. Understanding the mechanisms that regulate macrophage plasticity will be an important step towards realizing the potential of personalized immunomodulatory therapy. |
| first_indexed | 2024-04-10T01:06:46Z |
| format | Article |
| id | doaj.art-bd492de37fa74c2aa7650af32b1d8022 |
| institution | Directory Open Access Journal |
| issn | 1682-0363 1819-3684 |
| language | English |
| last_indexed | 2024-04-10T01:06:46Z |
| publishDate | 2019-05-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj.art-bd492de37fa74c2aa7650af32b1d80222023-03-13T09:58:24ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842019-05-0118114215410.20538/1682-0363-2019-1-142-1541488Macrophages in bacterial lung diseases: phenotype and functions (review)E. G. Churina0A. V. Sitnikova1O. I. Urazova2S. P. Chumakova3M. V. Vins4A. E. Beresneva5V. V. Novitskii6Сибирский государственный медицинский университет (СибГМУ); Национальный исследовательский Томский государственный университет (НИ ТГУ)Сибирский государственный медицинский университет (СибГМУ)Сибирский государственный медицинский университет (СибГМУ); Томский государственный университет систем управления и радиоэлектроники (ТУСУР)Сибирский государственный медицинский университет (СибГМУ)Сибирский государственный медицинский университет (СибГМУ)Сибирский государственный медицинский университет (СибГМУ)Сибирский государственный медицинский университет (СибГМУ); Томский государственный университет систем управления и радиоэлектроники (ТУСУР)This literature review is devoted to the analysis of the role of macrophages in the immunopathogenesis of infectious lung diseases of bacterial etiology. The article summarizes information about the origin of macrophages, their phenotypic and functional heterogeneity. The mechanisms of impaired protective function of innate immunity are associated with the polarization of the program of maturation and activation of macrophages in the direction to tolerogenic or immunoregulatory cells with phenotype of M2. Alveolar macrophages perform a variety of functions (from pro-inflammatory to regenerative) in the development of inflammation in the respiratory organs. Their inherent plasticity suggests that the same macrophages can change their phenotype and function depending on the microenvironment in the inflammatory focus at different stages of the disease. Understanding the mechanisms that regulate macrophage plasticity will be an important step towards realizing the potential of personalized immunomodulatory therapy.https://bulletin.ssmu.ru/jour/article/view/2178макрофагимоноцитыальвеолярные макрофагизаболевания легкихврожденный иммунитетиммунный ответ |
| spellingShingle | E. G. Churina A. V. Sitnikova O. I. Urazova S. P. Chumakova M. V. Vins A. E. Beresneva V. V. Novitskii Macrophages in bacterial lung diseases: phenotype and functions (review) Бюллетень сибирской медицины макрофаги моноциты альвеолярные макрофаги заболевания легких врожденный иммунитет иммунный ответ |
| title | Macrophages in bacterial lung diseases: phenotype and functions (review) |
| title_full | Macrophages in bacterial lung diseases: phenotype and functions (review) |
| title_fullStr | Macrophages in bacterial lung diseases: phenotype and functions (review) |
| title_full_unstemmed | Macrophages in bacterial lung diseases: phenotype and functions (review) |
| title_short | Macrophages in bacterial lung diseases: phenotype and functions (review) |
| title_sort | macrophages in bacterial lung diseases phenotype and functions review |
| topic | макрофаги моноциты альвеолярные макрофаги заболевания легких врожденный иммунитет иммунный ответ |
| url | https://bulletin.ssmu.ru/jour/article/view/2178 |
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