Screening of <i>Chlamydia trachomatis</i> and <i>Waddlia chondrophila</i> Antibodies in Women with Tubal Factor Infertility
<i>Waddlia chondrophila</i> is an emerging intracellular pathogen belonging to the order of <i>Chlamydiales</i>, and was previously associated with adverse pregnancy outcomes, as well as tubal factor infertility (TFI). In this study, we investigate the link between both <i...
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| Format: | Article |
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MDPI AG
2020-06-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/8/6/918 |
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| author | Wies T.M. van Dooremalen Stephan P. Verweij Janneke E. den Hartog Carole Kebbi-Beghdadi Sander Ouburg Gilbert Greub Servaas A. Morré Anne Ammerdorffer |
| author_facet | Wies T.M. van Dooremalen Stephan P. Verweij Janneke E. den Hartog Carole Kebbi-Beghdadi Sander Ouburg Gilbert Greub Servaas A. Morré Anne Ammerdorffer |
| author_sort | Wies T.M. van Dooremalen |
| collection | DOAJ |
| description | <i>Waddlia chondrophila</i> is an emerging intracellular pathogen belonging to the order of <i>Chlamydiales</i>, and was previously associated with adverse pregnancy outcomes, as well as tubal factor infertility (TFI). In this study, we investigate the link between both <i>W. chondrophila</i> and <i>Chlamydia trachomatis</i> IgG seropositivity and TFI. Antibodies against both bacteria were measured in 890 serum samples of women visiting a fertility clinic. After a hysterosalpingography and/or laparoscopy, they were classified as either TFI-negative (TFI−) or TFI-positive (TFI+). The total seroprevalence was 13.4% for <i>C. trachomatis</i> and 38.8% for <i>W. chondrophila</i>. <i>C. trachomatis</i> antibodies were present significantly more often in the TFI+ group than in the TFI− group, while for <i>W. chondrophila</i> no difference could be observed. In conclusion, our study confirms the association between <i>C. trachomatis</i> seropositivity and TFI, but no association was found between <i>W. chondrophila</i> seropositivity and TFI. The high percentage of <i>W. chondrophila</i> seropositivity in all women attending a fertility clinic does, however, demonstrate the need for further research on this <i>Chlamydia</i>-like bacterium and its possible role in infertility. |
| first_indexed | 2024-03-10T19:05:24Z |
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| language | English |
| last_indexed | 2024-03-10T19:05:24Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-bd49cff5b0604dfb96c9ae6e9a7aad8e2023-11-20T04:10:37ZengMDPI AGMicroorganisms2076-26072020-06-018691810.3390/microorganisms8060918Screening of <i>Chlamydia trachomatis</i> and <i>Waddlia chondrophila</i> Antibodies in Women with Tubal Factor InfertilityWies T.M. van Dooremalen0Stephan P. Verweij1Janneke E. den Hartog2Carole Kebbi-Beghdadi3Sander Ouburg4Gilbert Greub5Servaas A. Morré6Anne Ammerdorffer7Laboratory of Immunogenetics, Department of Medical Microbiology and Infection Control, Amsterdam UMC, Location AMC, 1105 AZ Amsterdam, The NetherlandsLaboratory of Immunogenetics, Department of Medical Microbiology and Infection Control, Amsterdam UMC, Location AMC, 1105 AZ Amsterdam, The NetherlandsDepartment of Obstetrics & Gynaecology, GROW School of Oncology and Developmental Biology, Maastricht University Medical Center+, 6229 ER Maastricht, The NetherlandsInstitute of Microbiology, University Hospital Center and University of Lausanne, 1011 Lausanne, SwitzerlandLaboratory of Immunogenetics, Department of Medical Microbiology and Infection Control, Amsterdam UMC, Location AMC, 1105 AZ Amsterdam, The NetherlandsInstitute of Microbiology, University Hospital Center and University of Lausanne, 1011 Lausanne, SwitzerlandLaboratory of Immunogenetics, Department of Medical Microbiology and Infection Control, Amsterdam UMC, Location AMC, 1105 AZ Amsterdam, The NetherlandsLaboratory of Immunogenetics, Department of Medical Microbiology and Infection Control, Amsterdam UMC, Location AMC, 1105 AZ Amsterdam, The Netherlands<i>Waddlia chondrophila</i> is an emerging intracellular pathogen belonging to the order of <i>Chlamydiales</i>, and was previously associated with adverse pregnancy outcomes, as well as tubal factor infertility (TFI). In this study, we investigate the link between both <i>W. chondrophila</i> and <i>Chlamydia trachomatis</i> IgG seropositivity and TFI. Antibodies against both bacteria were measured in 890 serum samples of women visiting a fertility clinic. After a hysterosalpingography and/or laparoscopy, they were classified as either TFI-negative (TFI−) or TFI-positive (TFI+). The total seroprevalence was 13.4% for <i>C. trachomatis</i> and 38.8% for <i>W. chondrophila</i>. <i>C. trachomatis</i> antibodies were present significantly more often in the TFI+ group than in the TFI− group, while for <i>W. chondrophila</i> no difference could be observed. In conclusion, our study confirms the association between <i>C. trachomatis</i> seropositivity and TFI, but no association was found between <i>W. chondrophila</i> seropositivity and TFI. The high percentage of <i>W. chondrophila</i> seropositivity in all women attending a fertility clinic does, however, demonstrate the need for further research on this <i>Chlamydia</i>-like bacterium and its possible role in infertility.https://www.mdpi.com/2076-2607/8/6/918<i>Waddlia chondrophila</i><i>Chlamydia trachomatis</i>tubal factor infertilityfemale reproductive healthserology |
| spellingShingle | Wies T.M. van Dooremalen Stephan P. Verweij Janneke E. den Hartog Carole Kebbi-Beghdadi Sander Ouburg Gilbert Greub Servaas A. Morré Anne Ammerdorffer Screening of <i>Chlamydia trachomatis</i> and <i>Waddlia chondrophila</i> Antibodies in Women with Tubal Factor Infertility Microorganisms <i>Waddlia chondrophila</i> <i>Chlamydia trachomatis</i> tubal factor infertility female reproductive health serology |
| title | Screening of <i>Chlamydia trachomatis</i> and <i>Waddlia chondrophila</i> Antibodies in Women with Tubal Factor Infertility |
| title_full | Screening of <i>Chlamydia trachomatis</i> and <i>Waddlia chondrophila</i> Antibodies in Women with Tubal Factor Infertility |
| title_fullStr | Screening of <i>Chlamydia trachomatis</i> and <i>Waddlia chondrophila</i> Antibodies in Women with Tubal Factor Infertility |
| title_full_unstemmed | Screening of <i>Chlamydia trachomatis</i> and <i>Waddlia chondrophila</i> Antibodies in Women with Tubal Factor Infertility |
| title_short | Screening of <i>Chlamydia trachomatis</i> and <i>Waddlia chondrophila</i> Antibodies in Women with Tubal Factor Infertility |
| title_sort | screening of i chlamydia trachomatis i and i waddlia chondrophila i antibodies in women with tubal factor infertility |
| topic | <i>Waddlia chondrophila</i> <i>Chlamydia trachomatis</i> tubal factor infertility female reproductive health serology |
| url | https://www.mdpi.com/2076-2607/8/6/918 |
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