Clinical pharmacists’ intervention on pain management in cancer patients (PharmaCAP trial): study protocol for a randomized controlled trial
Abstract Introduction Evidence-based services to support cancer patients with pain via clinical pharmacy services are currently lacking. Therefore, there is a need to undertake a randomized controlled trial (RCT) to explore the effectiveness of clinical pharmacists (CPs)’ input into the multidiscipl...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-01-01
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| Series: | Journal of Pharmaceutical Policy and Practice |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40545-022-00505-0 |
| _version_ | 1797329546515578880 |
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| author | Sunil Shrestha Ali Qais Blebil Siew Li Teoh Simit Sapkota Bhuvan KC Vibhu Paudyal Siew Hua Gan |
| author_facet | Sunil Shrestha Ali Qais Blebil Siew Li Teoh Simit Sapkota Bhuvan KC Vibhu Paudyal Siew Hua Gan |
| author_sort | Sunil Shrestha |
| collection | DOAJ |
| description | Abstract Introduction Evidence-based services to support cancer patients with pain via clinical pharmacy services are currently lacking. Therefore, there is a need to undertake a randomized controlled trial (RCT) to explore the effectiveness of clinical pharmacists (CPs)’ input into the multidisciplinary team (MDT) in providing better therapeutic outcomes for cancer pain management. Objectives The main aim of this pilot RCT is to determine the feasibility and preliminary efficacy of integrating CPs into the MDT for cancer pain management on the clinical outcomes of cancer patients experiencing pain. Methods This study protocol outlines two-armed multicenter pilot RCT. Cancer patients suffering from pain will be randomly allocated to receive either clinical pharmacy services, i.e., PharmaCAP trial intervention from the CP, or the usual standard care (i.e., control group). Patients will be recruited consecutively from two hospitals in Kathmandu valley, Nepal. The outcomes will be assessed at baseline (pre-intervention) and 4 weeks post-intervention. The primary feasibility outcomes will include eligibility rate, recruitment rate, willingness to participate, acceptability of screening procedures and random allocation, possible contamination between the groups, intervention fidelity and compliance, treatment satisfaction, and patient understanding of the provided interventions. Subsequently, the primary clinical outcome, i.e., pain intensity of cancer patients, will be assessed. The secondary clinical outcomes will include health-related quality of life (HRQoL), anxiety, depression, adverse drug reactions, and patient medication compliance following the integration of CP into the healthcare team. Discussion The feasibility and potential for integrating CP involvement in MDT to improve clinical outcomes of cancer patients with pain will be evaluated through the PharmaCAP trial. Trial registration: ClinicalTrials.gov NCT05021393. Registered on 25th August 2022. |
| first_indexed | 2024-03-08T07:07:05Z |
| format | Article |
| id | doaj.art-bd4a40be91de47c88d2a233c8c9a3899 |
| institution | Directory Open Access Journal |
| issn | 2052-3211 |
| language | English |
| last_indexed | 2024-03-08T07:07:05Z |
| publishDate | 2023-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Pharmaceutical Policy and Practice |
| spelling | doaj.art-bd4a40be91de47c88d2a233c8c9a38992024-02-03T04:31:34ZengTaylor & Francis GroupJournal of Pharmaceutical Policy and Practice2052-32112023-01-0116111210.1186/s40545-022-00505-0Clinical pharmacists’ intervention on pain management in cancer patients (PharmaCAP trial): study protocol for a randomized controlled trialSunil Shrestha0Ali Qais Blebil1Siew Li Teoh2Simit Sapkota3Bhuvan KC4Vibhu Paudyal5Siew Hua Gan6School of Pharmacy, Monash University MalaysiaSchool of Pharmacy, Monash University MalaysiaSchool of Pharmacy, Monash University MalaysiaDepartment of Clinical Oncology, Kathmandu Cancer CenterSchool of Pharmacy, Monash University MalaysiaSchool of Pharmacy, College of Medical and Dental Sciences, Sir Robert Aitken Institute for Medical Research, University of Birmingham EdgbastonSchool of Pharmacy, Monash University MalaysiaAbstract Introduction Evidence-based services to support cancer patients with pain via clinical pharmacy services are currently lacking. Therefore, there is a need to undertake a randomized controlled trial (RCT) to explore the effectiveness of clinical pharmacists (CPs)’ input into the multidisciplinary team (MDT) in providing better therapeutic outcomes for cancer pain management. Objectives The main aim of this pilot RCT is to determine the feasibility and preliminary efficacy of integrating CPs into the MDT for cancer pain management on the clinical outcomes of cancer patients experiencing pain. Methods This study protocol outlines two-armed multicenter pilot RCT. Cancer patients suffering from pain will be randomly allocated to receive either clinical pharmacy services, i.e., PharmaCAP trial intervention from the CP, or the usual standard care (i.e., control group). Patients will be recruited consecutively from two hospitals in Kathmandu valley, Nepal. The outcomes will be assessed at baseline (pre-intervention) and 4 weeks post-intervention. The primary feasibility outcomes will include eligibility rate, recruitment rate, willingness to participate, acceptability of screening procedures and random allocation, possible contamination between the groups, intervention fidelity and compliance, treatment satisfaction, and patient understanding of the provided interventions. Subsequently, the primary clinical outcome, i.e., pain intensity of cancer patients, will be assessed. The secondary clinical outcomes will include health-related quality of life (HRQoL), anxiety, depression, adverse drug reactions, and patient medication compliance following the integration of CP into the healthcare team. Discussion The feasibility and potential for integrating CP involvement in MDT to improve clinical outcomes of cancer patients with pain will be evaluated through the PharmaCAP trial. Trial registration: ClinicalTrials.gov NCT05021393. Registered on 25th August 2022.https://doi.org/10.1186/s40545-022-00505-0Cancer painCancer patientsClinical pharmacistFeasibility studyPilot trialRandomized controlled trial |
| spellingShingle | Sunil Shrestha Ali Qais Blebil Siew Li Teoh Simit Sapkota Bhuvan KC Vibhu Paudyal Siew Hua Gan Clinical pharmacists’ intervention on pain management in cancer patients (PharmaCAP trial): study protocol for a randomized controlled trial Journal of Pharmaceutical Policy and Practice Cancer pain Cancer patients Clinical pharmacist Feasibility study Pilot trial Randomized controlled trial |
| title | Clinical pharmacists’ intervention on pain management in cancer patients (PharmaCAP trial): study protocol for a randomized controlled trial |
| title_full | Clinical pharmacists’ intervention on pain management in cancer patients (PharmaCAP trial): study protocol for a randomized controlled trial |
| title_fullStr | Clinical pharmacists’ intervention on pain management in cancer patients (PharmaCAP trial): study protocol for a randomized controlled trial |
| title_full_unstemmed | Clinical pharmacists’ intervention on pain management in cancer patients (PharmaCAP trial): study protocol for a randomized controlled trial |
| title_short | Clinical pharmacists’ intervention on pain management in cancer patients (PharmaCAP trial): study protocol for a randomized controlled trial |
| title_sort | clinical pharmacists intervention on pain management in cancer patients pharmacap trial study protocol for a randomized controlled trial |
| topic | Cancer pain Cancer patients Clinical pharmacist Feasibility study Pilot trial Randomized controlled trial |
| url | https://doi.org/10.1186/s40545-022-00505-0 |
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