Biomimetic Black Phosphorus Nanosheet-Based Drug Delivery System for Targeted Photothermal-Chemo Cancer Therapy
As a biodegradable material, black phosphorus (BP) has been considered as an efficient agent for cancer photothermal therapy. However, its systemic delivery faces several hurdles, including rapid degradation in blood circulation, quick clearance by the immune system, and low delivery sufficiency to...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2021.707208/full |
| _version_ | 1818433614468087808 |
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| author | Jinxiu Cao Junyang Qi Xun Lin Yue Xiong Fumei He Wenbin Deng Gan Liu |
| author_facet | Jinxiu Cao Junyang Qi Xun Lin Yue Xiong Fumei He Wenbin Deng Gan Liu |
| author_sort | Jinxiu Cao |
| collection | DOAJ |
| description | As a biodegradable material, black phosphorus (BP) has been considered as an efficient agent for cancer photothermal therapy. However, its systemic delivery faces several hurdles, including rapid degradation in blood circulation, quick clearance by the immune system, and low delivery sufficiency to the tumor site. Here, we developed a biomimetic nanoparticle platform for in vivo tumor-targeted delivery of BP nanosheets (BP NSs). Through a biomimetic strategy, BP NSs were utilized to coordinate with the active species of oxaliplatin (1,2-diaminocyclohexane) platinum (II) (DACHPt) complexions, and the nanoparticles were further camouflaged with mesenchymal stem cell (MSC)–derived membranes. We showed that the incorporation of DACHPt not only decelerated the BP degradation but also enhanced the antitumor effect by combining the photothermal effect with chemotoxicity. Furthermore, MSC membrane coating increased the stability, dispersibility, and tumor-targeting properties of BP/DACHPt, significantly improving the antitumor efficacy. In short, our work not only provided a new strategy for in vivo tumor-targeted delivery of BP NSs but also obtained an enhanced antitumor effect by combining photothermal therapy with chemotherapy. |
| first_indexed | 2024-12-14T16:23:54Z |
| format | Article |
| id | doaj.art-bd4ca9f87733437f8cd3a80c76e3c949 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-14T16:23:54Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-bd4ca9f87733437f8cd3a80c76e3c9492022-12-21T22:54:44ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852021-08-01910.3389/fbioe.2021.707208707208Biomimetic Black Phosphorus Nanosheet-Based Drug Delivery System for Targeted Photothermal-Chemo Cancer TherapyJinxiu CaoJunyang QiXun LinYue XiongFumei HeWenbin DengGan LiuAs a biodegradable material, black phosphorus (BP) has been considered as an efficient agent for cancer photothermal therapy. However, its systemic delivery faces several hurdles, including rapid degradation in blood circulation, quick clearance by the immune system, and low delivery sufficiency to the tumor site. Here, we developed a biomimetic nanoparticle platform for in vivo tumor-targeted delivery of BP nanosheets (BP NSs). Through a biomimetic strategy, BP NSs were utilized to coordinate with the active species of oxaliplatin (1,2-diaminocyclohexane) platinum (II) (DACHPt) complexions, and the nanoparticles were further camouflaged with mesenchymal stem cell (MSC)–derived membranes. We showed that the incorporation of DACHPt not only decelerated the BP degradation but also enhanced the antitumor effect by combining the photothermal effect with chemotoxicity. Furthermore, MSC membrane coating increased the stability, dispersibility, and tumor-targeting properties of BP/DACHPt, significantly improving the antitumor efficacy. In short, our work not only provided a new strategy for in vivo tumor-targeted delivery of BP NSs but also obtained an enhanced antitumor effect by combining photothermal therapy with chemotherapy.https://www.frontiersin.org/articles/10.3389/fbioe.2021.707208/fullbiomimetic nanoparticlesblack phosphorusdrug-self-stabilizationmesenchymal stem cell membranecombined chemo-photothermal cancer therapytargeted delivery |
| spellingShingle | Jinxiu Cao Junyang Qi Xun Lin Yue Xiong Fumei He Wenbin Deng Gan Liu Biomimetic Black Phosphorus Nanosheet-Based Drug Delivery System for Targeted Photothermal-Chemo Cancer Therapy Frontiers in Bioengineering and Biotechnology biomimetic nanoparticles black phosphorus drug-self-stabilization mesenchymal stem cell membrane combined chemo-photothermal cancer therapy targeted delivery |
| title | Biomimetic Black Phosphorus Nanosheet-Based Drug Delivery System for Targeted Photothermal-Chemo Cancer Therapy |
| title_full | Biomimetic Black Phosphorus Nanosheet-Based Drug Delivery System for Targeted Photothermal-Chemo Cancer Therapy |
| title_fullStr | Biomimetic Black Phosphorus Nanosheet-Based Drug Delivery System for Targeted Photothermal-Chemo Cancer Therapy |
| title_full_unstemmed | Biomimetic Black Phosphorus Nanosheet-Based Drug Delivery System for Targeted Photothermal-Chemo Cancer Therapy |
| title_short | Biomimetic Black Phosphorus Nanosheet-Based Drug Delivery System for Targeted Photothermal-Chemo Cancer Therapy |
| title_sort | biomimetic black phosphorus nanosheet based drug delivery system for targeted photothermal chemo cancer therapy |
| topic | biomimetic nanoparticles black phosphorus drug-self-stabilization mesenchymal stem cell membrane combined chemo-photothermal cancer therapy targeted delivery |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2021.707208/full |
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