Dynamics of Oxidative Stress in <i>Helicobacter pylori</i>-Positive Patients with Atrophic Body Gastritis and Various Stages of Gastric Cancer
Gastric cancer is a global health problem. The pathogenesis of this disease remains unclear. This study included 198 <i>H. pylori</i> (+) men aged 45 to 60 years old. Group A included 63 practically healthy men, group B included 45 men with severe atrophic body gastritis, group C include...
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| Format: | Article |
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MDPI AG
2022-05-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/5/1203 |
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| author | Vladislav Vladimirovich Tsukanov Olga Valentinovna Smirnova Edward Vilyamovich Kasparov Alexander Alexandrovich Sinyakov Alexander Viktorovich Vasyutin Julia Leongardovna Tonkikh Mikhail Alexandrovich Cherepnin |
| author_facet | Vladislav Vladimirovich Tsukanov Olga Valentinovna Smirnova Edward Vilyamovich Kasparov Alexander Alexandrovich Sinyakov Alexander Viktorovich Vasyutin Julia Leongardovna Tonkikh Mikhail Alexandrovich Cherepnin |
| author_sort | Vladislav Vladimirovich Tsukanov |
| collection | DOAJ |
| description | Gastric cancer is a global health problem. The pathogenesis of this disease remains unclear. This study included 198 <i>H. pylori</i> (+) men aged 45 to 60 years old. Group A included 63 practically healthy men, group B included 45 men with severe atrophic body gastritis, group C included 37 men with epithelial gastric cancer stages I–II according to TNM, and group D included 54 men with epithelial gastric cancer stages III–IV according to the TNM scale. The content of malondialdehyde (MDA), diene conjugates (DCs), superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), and glutathione peroxidase (GPO) was detected using an enzyme immunoassay (ELISA) or spectrophotometric methods in the blood plasma. The concentrations of MDA and DC were increased in the patients of group B compared with group A, and in patients of groups C and D compared with groups A and B. The ratio of MDA/SOD and MDA/CAT was decreased in the patients in group D compared with the patients in group C, and was significantly higher compared with group A. The ratios of MDA/GPO and MDA/GST increased linearly and were at a maximum in groups C and D. Our work determined that indicators of oxidative stress may be the biochemical substrate, which brings together the various stages of the Correa cascade, and may explain disease progression. The dynamics of changes in the content of SOD and CAT in the plasma in patients with gastric cancer may be a target of future investigations. |
| first_indexed | 2024-03-10T03:03:12Z |
| format | Article |
| id | doaj.art-bd4d5ffb4caf4c13a8992e1880e14b94 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T03:03:12Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-bd4d5ffb4caf4c13a8992e1880e14b942023-11-23T10:40:50ZengMDPI AGDiagnostics2075-44182022-05-01125120310.3390/diagnostics12051203Dynamics of Oxidative Stress in <i>Helicobacter pylori</i>-Positive Patients with Atrophic Body Gastritis and Various Stages of Gastric CancerVladislav Vladimirovich Tsukanov0Olga Valentinovna Smirnova1Edward Vilyamovich Kasparov2Alexander Alexandrovich Sinyakov3Alexander Viktorovich Vasyutin4Julia Leongardovna Tonkikh5Mikhail Alexandrovich Cherepnin6Scientific Research Institute of Medical Problems of the North, Federal Research Centre “Krasnoyarsk Science Centre” of the Siberian Branch of Russian Academy of Science, 660022 Krasnoyarsk, RussiaScientific Research Institute of Medical Problems of the North, Federal Research Centre “Krasnoyarsk Science Centre” of the Siberian Branch of Russian Academy of Science, 660022 Krasnoyarsk, RussiaScientific Research Institute of Medical Problems of the North, Federal Research Centre “Krasnoyarsk Science Centre” of the Siberian Branch of Russian Academy of Science, 660022 Krasnoyarsk, RussiaScientific Research Institute of Medical Problems of the North, Federal Research Centre “Krasnoyarsk Science Centre” of the Siberian Branch of Russian Academy of Science, 660022 Krasnoyarsk, RussiaScientific Research Institute of Medical Problems of the North, Federal Research Centre “Krasnoyarsk Science Centre” of the Siberian Branch of Russian Academy of Science, 660022 Krasnoyarsk, RussiaScientific Research Institute of Medical Problems of the North, Federal Research Centre “Krasnoyarsk Science Centre” of the Siberian Branch of Russian Academy of Science, 660022 Krasnoyarsk, RussiaScientific Research Institute of Medical Problems of the North, Federal Research Centre “Krasnoyarsk Science Centre” of the Siberian Branch of Russian Academy of Science, 660022 Krasnoyarsk, RussiaGastric cancer is a global health problem. The pathogenesis of this disease remains unclear. This study included 198 <i>H. pylori</i> (+) men aged 45 to 60 years old. Group A included 63 practically healthy men, group B included 45 men with severe atrophic body gastritis, group C included 37 men with epithelial gastric cancer stages I–II according to TNM, and group D included 54 men with epithelial gastric cancer stages III–IV according to the TNM scale. The content of malondialdehyde (MDA), diene conjugates (DCs), superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), and glutathione peroxidase (GPO) was detected using an enzyme immunoassay (ELISA) or spectrophotometric methods in the blood plasma. The concentrations of MDA and DC were increased in the patients of group B compared with group A, and in patients of groups C and D compared with groups A and B. The ratio of MDA/SOD and MDA/CAT was decreased in the patients in group D compared with the patients in group C, and was significantly higher compared with group A. The ratios of MDA/GPO and MDA/GST increased linearly and were at a maximum in groups C and D. Our work determined that indicators of oxidative stress may be the biochemical substrate, which brings together the various stages of the Correa cascade, and may explain disease progression. The dynamics of changes in the content of SOD and CAT in the plasma in patients with gastric cancer may be a target of future investigations.https://www.mdpi.com/2075-4418/12/5/1203atrophic gastritisgastric canceroxidative stresslipid peroxidationantioxidant protection<i>Helicobacter pylori</i> |
| spellingShingle | Vladislav Vladimirovich Tsukanov Olga Valentinovna Smirnova Edward Vilyamovich Kasparov Alexander Alexandrovich Sinyakov Alexander Viktorovich Vasyutin Julia Leongardovna Tonkikh Mikhail Alexandrovich Cherepnin Dynamics of Oxidative Stress in <i>Helicobacter pylori</i>-Positive Patients with Atrophic Body Gastritis and Various Stages of Gastric Cancer Diagnostics atrophic gastritis gastric cancer oxidative stress lipid peroxidation antioxidant protection <i>Helicobacter pylori</i> |
| title | Dynamics of Oxidative Stress in <i>Helicobacter pylori</i>-Positive Patients with Atrophic Body Gastritis and Various Stages of Gastric Cancer |
| title_full | Dynamics of Oxidative Stress in <i>Helicobacter pylori</i>-Positive Patients with Atrophic Body Gastritis and Various Stages of Gastric Cancer |
| title_fullStr | Dynamics of Oxidative Stress in <i>Helicobacter pylori</i>-Positive Patients with Atrophic Body Gastritis and Various Stages of Gastric Cancer |
| title_full_unstemmed | Dynamics of Oxidative Stress in <i>Helicobacter pylori</i>-Positive Patients with Atrophic Body Gastritis and Various Stages of Gastric Cancer |
| title_short | Dynamics of Oxidative Stress in <i>Helicobacter pylori</i>-Positive Patients with Atrophic Body Gastritis and Various Stages of Gastric Cancer |
| title_sort | dynamics of oxidative stress in i helicobacter pylori i positive patients with atrophic body gastritis and various stages of gastric cancer |
| topic | atrophic gastritis gastric cancer oxidative stress lipid peroxidation antioxidant protection <i>Helicobacter pylori</i> |
| url | https://www.mdpi.com/2075-4418/12/5/1203 |
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