Isolated Right Ventricular Metastasis in a Woman with Advanced Hepatocellular Carcinoma after Palliative Therapy
Hepatocellular carcinoma (HCC) with cardiac metastasis represents a group of rarity and poor prognosis. Few case reports have described this patient entity, and it remains unclear regarding the optimal treatment and predicted outcome for these patients. In our case, we represented a 67-year-old fema...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2019-11-01
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| Series: | Case Reports in Gastroenterology |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/504566 |
| _version_ | 1818450630663995392 |
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| author | Chun-Ting Fan Wei-Wen Lin Ming-Jer Chen Sz-Iuan Shiu |
| author_facet | Chun-Ting Fan Wei-Wen Lin Ming-Jer Chen Sz-Iuan Shiu |
| author_sort | Chun-Ting Fan |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) with cardiac metastasis represents a group of rarity and poor prognosis. Few case reports have described this patient entity, and it remains unclear regarding the optimal treatment and predicted outcome for these patients. In our case, we represented a 67-year-old female patient with presentations of dyspnea and heart murmur, which conducted to the diagnosis of advanced HCC with isolated right ventricular metastasis. Because of multiple comorbidities regarding cardiac and pulmonary systems, she received best supportive care and survived 2 months after initial diagnosis. A systemic literature review of 80 published cases (including our patient) since the 1950s was also performed from PubMed, and the data were gathered from the medical record and literature reviews. In our review, patients with advanced HCC and cardiac metastasis involved the right heart mainly with a predominance of right atrium (53%). Meanwhile the overall 3-month survival rate in our review was 70.7%. In subgroup analysis, the overall 3-month survival was highest (97%) in patients treated with surgery and other therapies, and lowest (27%) in patients with best supportive care. To our knowledge, this is the first comprehensive literature review addressing the epidemiology, optimal treatment, and prognosis for advanced-stage HCC with cardiac metastasis. We suggest that abnormal cardiac murmur in patients with history of HCC should prompt investigation for tumor involvement of the heart. We also emphasize individualized treatment as well as prognostic measurement accordingly. |
| first_indexed | 2024-12-14T20:54:22Z |
| format | Article |
| id | doaj.art-bd4ddfd791b24b0da906f9bb8bb90150 |
| institution | Directory Open Access Journal |
| issn | 1662-0631 |
| language | English |
| last_indexed | 2024-12-14T20:54:22Z |
| publishDate | 2019-11-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Gastroenterology |
| spelling | doaj.art-bd4ddfd791b24b0da906f9bb8bb901502022-12-21T22:47:43ZengKarger PublishersCase Reports in Gastroenterology1662-06312019-11-0113348749710.1159/000504566504566Isolated Right Ventricular Metastasis in a Woman with Advanced Hepatocellular Carcinoma after Palliative TherapyChun-Ting FanWei-Wen LinMing-Jer ChenSz-Iuan ShiuHepatocellular carcinoma (HCC) with cardiac metastasis represents a group of rarity and poor prognosis. Few case reports have described this patient entity, and it remains unclear regarding the optimal treatment and predicted outcome for these patients. In our case, we represented a 67-year-old female patient with presentations of dyspnea and heart murmur, which conducted to the diagnosis of advanced HCC with isolated right ventricular metastasis. Because of multiple comorbidities regarding cardiac and pulmonary systems, she received best supportive care and survived 2 months after initial diagnosis. A systemic literature review of 80 published cases (including our patient) since the 1950s was also performed from PubMed, and the data were gathered from the medical record and literature reviews. In our review, patients with advanced HCC and cardiac metastasis involved the right heart mainly with a predominance of right atrium (53%). Meanwhile the overall 3-month survival rate in our review was 70.7%. In subgroup analysis, the overall 3-month survival was highest (97%) in patients treated with surgery and other therapies, and lowest (27%) in patients with best supportive care. To our knowledge, this is the first comprehensive literature review addressing the epidemiology, optimal treatment, and prognosis for advanced-stage HCC with cardiac metastasis. We suggest that abnormal cardiac murmur in patients with history of HCC should prompt investigation for tumor involvement of the heart. We also emphasize individualized treatment as well as prognostic measurement accordingly.https://www.karger.com/Article/FullText/504566advanced hepatocellular carcinomacardiac metastasiscase report |
| spellingShingle | Chun-Ting Fan Wei-Wen Lin Ming-Jer Chen Sz-Iuan Shiu Isolated Right Ventricular Metastasis in a Woman with Advanced Hepatocellular Carcinoma after Palliative Therapy Case Reports in Gastroenterology advanced hepatocellular carcinoma cardiac metastasis case report |
| title | Isolated Right Ventricular Metastasis in a Woman with Advanced Hepatocellular Carcinoma after Palliative Therapy |
| title_full | Isolated Right Ventricular Metastasis in a Woman with Advanced Hepatocellular Carcinoma after Palliative Therapy |
| title_fullStr | Isolated Right Ventricular Metastasis in a Woman with Advanced Hepatocellular Carcinoma after Palliative Therapy |
| title_full_unstemmed | Isolated Right Ventricular Metastasis in a Woman with Advanced Hepatocellular Carcinoma after Palliative Therapy |
| title_short | Isolated Right Ventricular Metastasis in a Woman with Advanced Hepatocellular Carcinoma after Palliative Therapy |
| title_sort | isolated right ventricular metastasis in a woman with advanced hepatocellular carcinoma after palliative therapy |
| topic | advanced hepatocellular carcinoma cardiac metastasis case report |
| url | https://www.karger.com/Article/FullText/504566 |
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