Anticatabolic activity of alpha-ketoglutaric acid in growing rats
This study evaluated the anti-catabolic effect of α-ketoglutaric acid (AKG) in rats. Thirty Sprague Dowley male rats were divided into 3 groups of 10 animals each and fed a<em>d libitum</em> with protein-free diet (PFD) supplemented with 0, 3, and 6 g/kg feed of AKG for 14 consecutive da...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2012-07-01
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| Series: | Italian Journal of Animal Science |
| Subjects: | |
| Online Access: | http://www.aspajournal.it/index.php/ijas/article/view/2514 |
| _version_ | 1811299360726581248 |
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| author | Lucia Fiorentini Samantha Sigolo Mauro Morlacchini Aldo Prandini |
| author_facet | Lucia Fiorentini Samantha Sigolo Mauro Morlacchini Aldo Prandini |
| author_sort | Lucia Fiorentini |
| collection | DOAJ |
| description | This study evaluated the anti-catabolic effect of α-ketoglutaric acid (AKG) in rats. Thirty Sprague Dowley male rats were divided into 3 groups of 10 animals each and fed a<em>d libitum</em> with protein-free diet (PFD) supplemented with 0, 3, and 6 g/kg feed of AKG for 14 consecutive days. The AKG administration had no effect on the growth performance of rats in the global trial period (0-14 d). After 7 d of excreta collection, the losses of endogenous nitrogen (N), both urinary and total, linearly reduced (P<0.05) following the administration of AKG, ranging from 35.00 mg/d to 28.00 mg/d, and from 45.28 mg/d to 36.36 mg/d, respectively. The villi and microvilli heights were lower when animals received 3 g/kg of AKG respecting to other tested AKG levels. Indeed, enterocytes length linearly increased (P<0.05) as the level of AKG increased in the diet by 25.0% (3 g/kg) and 49.0% (6 g/kg). The AKG levels quadratically influenced (P<0.05) the essential amino acids (EAA) concentrations in the blood, being EAA lower for animals treated with 6 g/kg of AKG (-21.6%) compared to the animals fed the control PFD and the PFD with 3 g/kg of AKG. In conclusion, AKG was effective in reducing catabolism and EAA depletion. |
| first_indexed | 2024-04-13T06:34:56Z |
| format | Article |
| id | doaj.art-bd501b59b23545c3b6ca67bb1bb03031 |
| institution | Directory Open Access Journal |
| issn | 1594-4077 1828-051X |
| language | English |
| last_indexed | 2024-04-13T06:34:56Z |
| publishDate | 2012-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Italian Journal of Animal Science |
| spelling | doaj.art-bd501b59b23545c3b6ca67bb1bb030312022-12-22T02:57:57ZengTaylor & Francis GroupItalian Journal of Animal Science1594-40771828-051X2012-07-01113e52e5210.4081/ijas.2012.e52Anticatabolic activity of alpha-ketoglutaric acid in growing ratsLucia FiorentiniSamantha SigoloMauro MorlacchiniAldo PrandiniThis study evaluated the anti-catabolic effect of α-ketoglutaric acid (AKG) in rats. Thirty Sprague Dowley male rats were divided into 3 groups of 10 animals each and fed a<em>d libitum</em> with protein-free diet (PFD) supplemented with 0, 3, and 6 g/kg feed of AKG for 14 consecutive days. The AKG administration had no effect on the growth performance of rats in the global trial period (0-14 d). After 7 d of excreta collection, the losses of endogenous nitrogen (N), both urinary and total, linearly reduced (P<0.05) following the administration of AKG, ranging from 35.00 mg/d to 28.00 mg/d, and from 45.28 mg/d to 36.36 mg/d, respectively. The villi and microvilli heights were lower when animals received 3 g/kg of AKG respecting to other tested AKG levels. Indeed, enterocytes length linearly increased (P<0.05) as the level of AKG increased in the diet by 25.0% (3 g/kg) and 49.0% (6 g/kg). The AKG levels quadratically influenced (P<0.05) the essential amino acids (EAA) concentrations in the blood, being EAA lower for animals treated with 6 g/kg of AKG (-21.6%) compared to the animals fed the control PFD and the PFD with 3 g/kg of AKG. In conclusion, AKG was effective in reducing catabolism and EAA depletion.http://www.aspajournal.it/index.php/ijas/article/view/2514Rat, Alpha-ketoglutaric acid, Nitrogen balance, Free amino acids, Intestinal morphology. |
| spellingShingle | Lucia Fiorentini Samantha Sigolo Mauro Morlacchini Aldo Prandini Anticatabolic activity of alpha-ketoglutaric acid in growing rats Italian Journal of Animal Science Rat, Alpha-ketoglutaric acid, Nitrogen balance, Free amino acids, Intestinal morphology. |
| title | Anticatabolic activity of alpha-ketoglutaric acid in growing rats |
| title_full | Anticatabolic activity of alpha-ketoglutaric acid in growing rats |
| title_fullStr | Anticatabolic activity of alpha-ketoglutaric acid in growing rats |
| title_full_unstemmed | Anticatabolic activity of alpha-ketoglutaric acid in growing rats |
| title_short | Anticatabolic activity of alpha-ketoglutaric acid in growing rats |
| title_sort | anticatabolic activity of alpha ketoglutaric acid in growing rats |
| topic | Rat, Alpha-ketoglutaric acid, Nitrogen balance, Free amino acids, Intestinal morphology. |
| url | http://www.aspajournal.it/index.php/ijas/article/view/2514 |
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