Intratumoral Niches of B Cells and Follicular Helper T Cells, and the Absence of Regulatory T Cells, Associate with Longer Survival in Early-Stage Oral Tongue Cancer Patients

Intratumoral Niches of B Cells and Follicular Helper T Cells, and the Absence of Regulatory T Cells, Associate with Longer Survival in Early-Stage Oral Tongue Cancer Patients

In early oral squamous cell carcinoma (OSCC), the occurrence of clusters between CD20 B cells and CD4 T cells in the invasive margin (IM) can be captured by using the CD20 cluster score, and is positively associated with patient survival. However, the exact contribution of different CD4 T cell subse...

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Bibliographic Details
Main Authors: Chumut Phanthunane, Rebecca Wijers, Maria J. De Herdt, Senada Koljenović, Stefan Sleijfer, Robert J. Baatenburg de Jong, José Angelito U. Hardillo, Reno Debets, Hayri E. Balcioglu
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cancers
Subjects:
tumor microenvironment
multiplex in situ staining
B cell
oral cancer
follicular helper T cells
regulatory T cells
Online Access:https://www.mdpi.com/2072-6694/14/17/4298

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