High-throughput in situ perturbation of metabolite levels in the tumor micro-environment reveals favorable metabolic condition for increased fitness of infiltrated T-cells

High-throughput in situ perturbation of metabolite levels in the tumor micro-environment reveals favorable metabolic condition for increased fitness of infiltrated T-cells

Tumor-infiltrating immune cells experience significant metabolic reprogramming in the tumor microenvironment (TME), and they share similar metabolic pathways and nutrient needs with malignant cells. This positions these cell types in direct nutrient competition in the TME. We currently lack a comple...

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Bibliographic Details
Main Authors: Veronica Valvo, Elena Parietti, Kyle Deans, Sebastian W. Ahn, Noel Ruth Park, Benjamin Ferland, Devon Thompson, Christine Dominas, Sharath K. Bhagavatula, Shawn Davidson, Oliver Jonas
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
tumor micro-environment
immunometabolism
cancer metabolism
immunotherapy
T-cells infiltration
in situ perturbation
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.1032360/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.1032360/full

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