Afucosylated broadly neutralizing antibodies enhance clearance of HIV-1 infected cells through cell-mediated killing

Afucosylated broadly neutralizing antibodies enhance clearance of HIV-1 infected cells through cell-mediated killing

Abstract Broadly neutralizing antibodies (bNAbs) targeting the HIV-1 envelope glycoprotein (Env) have the capacity to delay viral rebound when administered to people with HIV-1 (PWH) during anti-retroviral therapy (ART) interruption. To further enhance the performance of bNAbs through their Fc effec...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Steven W. de Taeye, Angela I. Schriek, Jeffrey C. Umotoy, Marloes Grobben, Judith A. Burger, Rogier W. Sanders, Gestur Vidarsson, Manfred Wuhrer, David Falck, Neeltje A. Kootstra, Marit J. van Gils
Μορφή:	Άρθρο
Γλώσσα:	English
Έκδοση:	Nature Portfolio 2024-08-01
Σειρά:	Communications Biology
Διαθέσιμο Online:	https://doi.org/10.1038/s42003-024-06659-8

Παρόμοια τεκμήρια

PP 8.8 – 00129 Antibody mediated killing of HIV-1 infected cells with glycoengineered broadly neutralizing antibodies
ανά: S. De Taeye, κ.ά.
Έκδοση: (2022-12-01)

A functional spleen contributes to afucosylated IgG in humans
ανά: Iwona Wojcik, κ.ά.
Έκδοση: (2021-12-01)

Acquisition of Fc-afucosylation of PfEMP1-specific IgG is age-dependent and associated with clinical protection against malaria
ανά: Mary Lopez-Perez, κ.ά.
Έκδοση: (2025-01-01)

Corrigendum: Anti-HIV-1 nanobody-IgG1 constructs with improved neutralization potency and the ability to mediate Fc effector functions
ανά: Angela I. Schriek, κ.ά.
Έκδοση: (2022-11-01)

Anti-HIV-1 Nanobody-IgG1 Constructs With Improved Neutralization Potency and the Ability to Mediate Fc Effector Functions
ανά: Angela I. Schriek, κ.ά.
Έκδοση: (2022-05-01)

Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination
ανά: Mads Delbo Larsen, κ.ά.
Έκδοση: (2021-10-01)

PP 8.5 – 00080 Fc-engineering of anti-HIV-1 antibodies and nanobodies to improve Fc mediated effector functions
ανά: A. Schriek, κ.ά.
Έκδοση: (2022-12-01)

Antibody Afucosylation Augments CD16-Mediated Serial Killing and IFNγ Secretion by Human Natural Killer Cells
ανά: Alexandros Karampatzakis, κ.ά.
Έκδοση: (2021-03-01)

Polyfunctionality and breadth of HIV-1 antibodies are associated with delayed disease progression.
ανά: Marloes Grobben, κ.ά.
Έκδοση: (2024-12-01)

The Ligands for Human IgG and Their Effector Functions
ανά: Steven W. de Taeye, κ.ά.
Έκδοση: (2019-04-01)

MS-Based Allotype-Specific Analysis of Polyclonal IgG-Fc N-Glycosylation
ανά: Thomas Sénard, κ.ά.
Έκδοση: (2020-08-01)

Primary SARS-CoV-2 variant of concern infections elicit broad antibody Fc-mediated effector functions and memory B cell responses.
ανά: Karlijn van der Straten, κ.ά.
Έκδοση: (2024-08-01)

Therapeutic afucosylated monoclonal antibody and bispecific T-cell engagers for T-cell acute lymphoblastic leukemia
ανά: Daniele Caracciolo, κ.ά.
Έκδοση: (2021-02-01)

Antibody Conjugates for Targeted Therapy Against HIV-1 as an Emerging Tool for HIV-1 Cure
ανά: Jeffrey C. Umotoy, κ.ά.
Έκδοση: (2021-07-01)

FcγR Binding and ADCC Activity of Human IgG Allotypes
ανά: Steven W. de Taeye, κ.ά.
Έκδοση: (2020-05-01)

Fc gamma receptor IIIb binding of individual antibody proteoforms resolved by affinity chromatography–mass spectrometry
ανά: Steffen Lippold, κ.ά.
Έκδοση: (2021-01-01)

Glycoform-resolved FcɣRIIIa affinity chromatography–mass spectrometry
ανά: Steffen Lippold, κ.ά.
Έκδοση: (2019-10-01)

Differences in IgG afucosylation between groups with and without carotid atherosclerosis
ανά: Cuihong Tian, κ.ά.
Έκδοση: (2024-11-01)

Kill and Clearance in HCC: An Approach Based on NK Cells and Macrophages
ανά: Maryam Mehrabi, κ.ά.
Έκδοση: (2021-09-01)

Fc-Glycosylation in Human IgG1 and IgG3 Is Similar for Both Total and Anti-Red-Blood Cell Anti-K Antibodies
ανά: Myrthe E. Sonneveld, κ.ά.
Έκδοση: (2018-01-01)

Mechanism of glycoform specificity and in vivo protection by an anti-afucosylated IgG nanobody
ανά: Aaron Gupta, κ.ά.
Έκδοση: (2023-05-01)

Targeting Tn-positive tumors with an afucosylated recombinant anti-Tn IgG
ανά: Yasuyuki Matsumoto, κ.ά.
Έκδοση: (2023-03-01)

Affinity capillary electrophoresis – mass spectrometry permits direct binding assessment of IgG and FcγRIIa in a glycoform-resolved manner
ανά: Christoph Gstöttner, κ.ά.
Έκδοση: (2022-09-01)

Understanding antibody-dependent enhancement in dengue: are afucosylated IgG1s a concern?
ανά: Teo, Andrew, κ.ά.
Έκδοση: (2023)

Understanding antibody-dependent enhancement in dengue: Are afucosylated IgG1s a concern?
ανά: Andrew Teo, κ.ά.
Έκδοση: (2023-03-01)

Understanding antibody-dependent enhancement in dengue: Are afucosylated IgG1s a concern?
ανά: Andrew Teo, κ.ά.
Έκδοση: (2023-03-01)

Enhancement of effector functions of anti-CD20 monoclonal antibody by increased afucosylation in CHO cell line through cell culture medium optimization
ανά: Bala Reddy Bheemareddy, κ.ά.
Έκδοση: (2022-10-01)

Clearance of therapeutic antibody glycoforms after subcutaneous and intravenous injection in a porcine model
ανά: David Falck, κ.ά.
Έκδοση: (2022-12-01)

N-linked Fc glycosylation is not required for IgG-B-cell receptor function in a GC-derived B-cell line
ανά: Theresa Kissel, κ.ά.
Έκδοση: (2024-01-01)

Patients with IgG1-anti-red blood cell autoantibodies show aberrant Fc-glycosylation
ανά: Myrthe E. Sonneveld, κ.ά.
Έκδοση: (2017-08-01)

Assessment of the role of afucosylated glycoforms on the in vitro antibody-dependent phagocytosis activity of an antibody to Aβ aggregates
ανά: Allyson Kwiatkowski, κ.ά.
Έκδοση: (2020-01-01)

The BNT162b2 mRNA SARS-CoV-2 vaccine induces transient afucosylated IgG1 in naive but not in antigen-experienced vaccineesResearch in context
ανά: Julie Van Coillie, κ.ά.
Έκδοση: (2023-01-01)

Specific location of galactosylation in an afucosylated antiviral monoclonal antibody affects its FcγRIIIA binding affinity
ανά: Grayson Hatfield, κ.ά.
Έκδοση: (2022-10-01)

Factors affecting IgG4-mediated complement activation
ανά: Nienke Oskam, κ.ά.
Έκδοση: (2023-01-01)

CD25 targeting with the afucosylated human IgG1 antibody RG6292 eliminates regulatory T cells and CD25+ blasts in acute myeloid leukemia
ανά: Laurène Pousse, κ.ά.
Έκδοση: (2023-05-01)

Detection of Antibody-Dependent Cell-Mediated Cytotoxicity—Supporting Antibodies by NK-92-CD16A Cell Externalization of CD107a: Recognition of Antibody Afucosylation and Assay Optimization
ανά: Judith Cruz Amaya, κ.ά.
Έκδοση: (2023-06-01)

Trends in SPR Cytometry: Advances in Label-Free Detection of Cell Parameters
ανά: Richard B. M. Schasfoort, κ.ά.
Έκδοση: (2018-10-01)

Robust Vaccine-Induced as Well as Hybrid B- and T-Cell Immunity across SARS-CoV-2 Vaccine Platforms in People with HIV
ανά: Myrthe L. Verburgh, κ.ά.
Έκδοση: (2023-06-01)

Proteoform-Resolved FcɤRIIIa Binding Assay for Fab Glycosylated Monoclonal Antibodies Achieved by Affinity Chromatography Mass Spectrometry of Fc Moieties
ανά: Steffen Lippold, κ.ά.
Έκδοση: (2019-10-01)

Antibodies and their receptors: different potential roles in mucosal defence
ανά: Rachel eHorton, κ.ά.
Έκδοση: (2013-07-01)