Afucosylated broadly neutralizing antibodies enhance clearance of HIV-1 infected cells through cell-mediated killing

Abstract Broadly neutralizing antibodies (bNAbs) targeting the HIV-1 envelope glycoprotein (Env) have the capacity to delay viral rebound when administered to people with HIV-1 (PWH) during anti-retroviral therapy (ART) interruption. To further enhance the performance of bNAbs through their Fc effec...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Steven W. de Taeye, Angela I. Schriek, Jeffrey C. Umotoy, Marloes Grobben, Judith A. Burger, Rogier W. Sanders, Gestur Vidarsson, Manfred Wuhrer, David Falck, Neeltje A. Kootstra, Marit J. van Gils
التنسيق: مقال
اللغة:English
منشور في: Nature Portfolio 2024-08-01
سلاسل:Communications Biology
الوصول للمادة أونلاين:https://doi.org/10.1038/s42003-024-06659-8