Exploring the eligibility of all reported lipoarabinomannan-testing assays in different clinical situations: a systematic review and meta-analysis of 97 articles
Objectives: How to choose proper lipoarabinomannan-testing assays for diagnosing tuberculosis (TB) in different populations baffles clinicians. This work assessed all reported lipoarabinomannan assays’ performance and aimed to identify the eligibility of each assay and offer guidance for clinicians....
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971222005537 |
| _version_ | 1797980391343128576 |
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| author | Mengyuan Lyu Yanbing Zhou Yi Chen Hongli Lai Yili Wang Yuhui Cheng Jing Li Wu Peng Tangyuheng Liu Xin Jiang Mei Li Zhenzhen Zhao Binwu Ying |
| author_facet | Mengyuan Lyu Yanbing Zhou Yi Chen Hongli Lai Yili Wang Yuhui Cheng Jing Li Wu Peng Tangyuheng Liu Xin Jiang Mei Li Zhenzhen Zhao Binwu Ying |
| author_sort | Mengyuan Lyu |
| collection | DOAJ |
| description | Objectives: How to choose proper lipoarabinomannan-testing assays for diagnosing tuberculosis (TB) in different populations baffles clinicians. This work assessed all reported lipoarabinomannan assays’ performance and aimed to identify the eligibility of each assay and offer guidance for clinicians. Methods: We searched PubMed, Embase, and Web of Science until August 23, 2020. The risk of bias was evaluated by QADAS-2. Heterogeneity was evaluated by the Cochran Q test and I2. Sensitivity and specificity were pooled by a bivariate mixed model (register number: CRD42021270506). Results: A total of 97 articles, covering 144 trials, 16 assays, 45,679 participants, and eight sample types, were divided into five groups. Electrochemiluminescence (ECL) had a sensitivity of 65%, specificity of 92%, and an area under curve (AUC) of 0.85 in diagnosing pulmonary TB in adults. ECL showed a promising diagnostic ability (sensitivity: 78%; specificity: 88%; AUC: 0.88) in patients with HIV, especially for urine detection (sensitivity: 90%; specificity: 89%; AUC: 0.95). The enzyme-linked immune assay showed a preference for diagnosing TB in Asians and Africans, especially in Africans who were smear-positive (sensitivity: 80%; specificity: 88%; AUC: 0.91). Conclusion: ECL was recommended for diagnosing pulmonary TB in adults, especially for TB/HIV co-infection. Taking urine as a sample further enhanced ECL's diagnostic performance. Enzyme-linked immune assay was recommended as an additional TB-related detection for smear-positive Africans. |
| first_indexed | 2024-04-11T05:53:29Z |
| format | Article |
| id | doaj.art-bd55dbc308e042589cfa257522c22d97 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-04-11T05:53:29Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-bd55dbc308e042589cfa257522c22d972022-12-22T04:41:58ZengElsevierInternational Journal of Infectious Diseases1201-97122022-12-011251934Exploring the eligibility of all reported lipoarabinomannan-testing assays in different clinical situations: a systematic review and meta-analysis of 97 articlesMengyuan Lyu0Yanbing Zhou1Yi Chen2Hongli Lai3Yili Wang4Yuhui Cheng5Jing Li6Wu Peng7Tangyuheng Liu8Xin Jiang9Mei Li10Zhenzhen Zhao11Binwu Ying12Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, 610044, China; West China School of Medicine, Sichuan University, Chengdu, 610044, ChinaDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, 610044, China; West China School of Medicine, Sichuan University, Chengdu, 610044, ChinaDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, 610044, China; West China School of Medicine, Sichuan University, Chengdu, 610044, ChinaWest China School of Medicine, Sichuan University, Chengdu, 610044, ChinaDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, 610044, China; West China School of Medicine, Sichuan University, Chengdu, 610044, ChinaDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, 610044, China; West China School of Medicine, Sichuan University, Chengdu, 610044, ChinaDepartment of Laboratory Medicine, PanZhihua Central Hospital, PanZhihua, 617067, ChinaDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, 610044, China; West China School of Medicine, Sichuan University, Chengdu, 610044, ChinaDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, 610044, China; West China School of Medicine, Sichuan University, Chengdu, 610044, ChinaDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, 610044, China; West China School of Medicine, Sichuan University, Chengdu, 610044, ChinaDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, 610044, China; West China School of Medicine, Sichuan University, Chengdu, 610044, ChinaDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, 610044, China; West China School of Medicine, Sichuan University, Chengdu, 610044, ChinaDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, 610044, China; West China School of Medicine, Sichuan University, Chengdu, 610044, China; Corresponding author: Binwu Ying, No. 37, Guoxue Alley, Chengdu, Sichuan 610041, China, Tel: +86 18980601655; Fax: 86-28-85422751Objectives: How to choose proper lipoarabinomannan-testing assays for diagnosing tuberculosis (TB) in different populations baffles clinicians. This work assessed all reported lipoarabinomannan assays’ performance and aimed to identify the eligibility of each assay and offer guidance for clinicians. Methods: We searched PubMed, Embase, and Web of Science until August 23, 2020. The risk of bias was evaluated by QADAS-2. Heterogeneity was evaluated by the Cochran Q test and I2. Sensitivity and specificity were pooled by a bivariate mixed model (register number: CRD42021270506). Results: A total of 97 articles, covering 144 trials, 16 assays, 45,679 participants, and eight sample types, were divided into five groups. Electrochemiluminescence (ECL) had a sensitivity of 65%, specificity of 92%, and an area under curve (AUC) of 0.85 in diagnosing pulmonary TB in adults. ECL showed a promising diagnostic ability (sensitivity: 78%; specificity: 88%; AUC: 0.88) in patients with HIV, especially for urine detection (sensitivity: 90%; specificity: 89%; AUC: 0.95). The enzyme-linked immune assay showed a preference for diagnosing TB in Asians and Africans, especially in Africans who were smear-positive (sensitivity: 80%; specificity: 88%; AUC: 0.91). Conclusion: ECL was recommended for diagnosing pulmonary TB in adults, especially for TB/HIV co-infection. Taking urine as a sample further enhanced ECL's diagnostic performance. Enzyme-linked immune assay was recommended as an additional TB-related detection for smear-positive Africans.http://www.sciencedirect.com/science/article/pii/S1201971222005537TuberculosisLipoarabinomannan-testing assayDiagnostic performanceApplication scope |
| spellingShingle | Mengyuan Lyu Yanbing Zhou Yi Chen Hongli Lai Yili Wang Yuhui Cheng Jing Li Wu Peng Tangyuheng Liu Xin Jiang Mei Li Zhenzhen Zhao Binwu Ying Exploring the eligibility of all reported lipoarabinomannan-testing assays in different clinical situations: a systematic review and meta-analysis of 97 articles International Journal of Infectious Diseases Tuberculosis Lipoarabinomannan-testing assay Diagnostic performance Application scope |
| title | Exploring the eligibility of all reported lipoarabinomannan-testing assays in different clinical situations: a systematic review and meta-analysis of 97 articles |
| title_full | Exploring the eligibility of all reported lipoarabinomannan-testing assays in different clinical situations: a systematic review and meta-analysis of 97 articles |
| title_fullStr | Exploring the eligibility of all reported lipoarabinomannan-testing assays in different clinical situations: a systematic review and meta-analysis of 97 articles |
| title_full_unstemmed | Exploring the eligibility of all reported lipoarabinomannan-testing assays in different clinical situations: a systematic review and meta-analysis of 97 articles |
| title_short | Exploring the eligibility of all reported lipoarabinomannan-testing assays in different clinical situations: a systematic review and meta-analysis of 97 articles |
| title_sort | exploring the eligibility of all reported lipoarabinomannan testing assays in different clinical situations a systematic review and meta analysis of 97 articles |
| topic | Tuberculosis Lipoarabinomannan-testing assay Diagnostic performance Application scope |
| url | http://www.sciencedirect.com/science/article/pii/S1201971222005537 |
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