Change of Serum Biomarkers to Post-Thrombolytic Symptomatic Intracranial Hemorrhage in Stroke
BackgroundSymptomatic intracranial hemorrhage (sICH) is a terrible complication after intravenous alteplase in stroke, and numerous biomarkers have been investigated. However, the change of biomarkers to sICH has not been well determined.AimTo investigate the association between the change of biomar...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.889746/full |
| _version_ | 1811245003541839872 |
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| author | Yu Cui Xin-Hong Wang Yong Zhao Shao-Yuan Chen Bao-Ying Sheng Li-Hua Wang Hui-Sheng Chen |
| author_facet | Yu Cui Xin-Hong Wang Yong Zhao Shao-Yuan Chen Bao-Ying Sheng Li-Hua Wang Hui-Sheng Chen |
| author_sort | Yu Cui |
| collection | DOAJ |
| description | BackgroundSymptomatic intracranial hemorrhage (sICH) is a terrible complication after intravenous alteplase in stroke, and numerous biomarkers have been investigated. However, the change of biomarkers to sICH has not been well determined.AimTo investigate the association between the change of biomarkers and sICH.MethodsThis is a prospective cohort study, and patients with sICH within 24 h after thrombolysis were enrolled, while patients without sICH were matched by propensity score matching with a ratio of 1:1. The blood samples were collected before and 24 h after intravenous thrombolysis (IVT), and preset 49 serum biomarkers were measured by microarray analysis. Protein function enrichment analyses were performed to detect the association between the change of biomarkers and sICH.ResultsOf consecutive 358 patients, 7 patients with sICH in 24 h were assigned to the sICH group, while 7 matched patients without any ICH were assigned to the non-sICH group. A total of 9 biomarkers were found to significantly change before vs. after thrombolysis between groups, including increased biomarkers, such as brain-derived neurotrophic factor, C-C motif chemokine ligand (CCL)-24, interleukin (IL)-6, IL-10, IL-18, and vascular endothelial growth factor, and decreased biomarkers, such as CCL-11, intercellular adhesion molecule-1, and IL-7.ConclusionsThis is the first study to identify changes in serum biomarkers in patients with sICH after IVT, and found that 6 neuroinflammatory and 3 neuroprotective biomarkers may be associated with brain injury following post-thrombolytic sICH.Clinical Trial Registrationhttps://www.clinicaltrials.gov, identifier: NCT02854592. |
| first_indexed | 2024-04-12T14:33:37Z |
| format | Article |
| id | doaj.art-bd568fe98a26490e856abcefa88b50eb |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-12T14:33:37Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-bd568fe98a26490e856abcefa88b50eb2022-12-22T03:29:11ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-06-011310.3389/fneur.2022.889746889746Change of Serum Biomarkers to Post-Thrombolytic Symptomatic Intracranial Hemorrhage in StrokeYu Cui0Xin-Hong Wang1Yong Zhao2Shao-Yuan Chen3Bao-Ying Sheng4Li-Hua Wang5Hui-Sheng Chen6Department of Neurology, General Hospital of Northern Theatre Command, Shenyang, ChinaDepartment of Neurology, General Hospital of Northern Theatre Command, Shenyang, ChinaDepartment of Neurology, Haicheng Hospital of Traditional Chinese Medicine, Haicheng, ChinaDepartment of Neurology, Chinese People's Liberation Army 321 Hospital, Baicheng, ChinaDepartment of Neurology, Jiamusi University First Affiliated Hospital, Jiamusi, ChinaDepartment of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Neurology, General Hospital of Northern Theatre Command, Shenyang, ChinaBackgroundSymptomatic intracranial hemorrhage (sICH) is a terrible complication after intravenous alteplase in stroke, and numerous biomarkers have been investigated. However, the change of biomarkers to sICH has not been well determined.AimTo investigate the association between the change of biomarkers and sICH.MethodsThis is a prospective cohort study, and patients with sICH within 24 h after thrombolysis were enrolled, while patients without sICH were matched by propensity score matching with a ratio of 1:1. The blood samples were collected before and 24 h after intravenous thrombolysis (IVT), and preset 49 serum biomarkers were measured by microarray analysis. Protein function enrichment analyses were performed to detect the association between the change of biomarkers and sICH.ResultsOf consecutive 358 patients, 7 patients with sICH in 24 h were assigned to the sICH group, while 7 matched patients without any ICH were assigned to the non-sICH group. A total of 9 biomarkers were found to significantly change before vs. after thrombolysis between groups, including increased biomarkers, such as brain-derived neurotrophic factor, C-C motif chemokine ligand (CCL)-24, interleukin (IL)-6, IL-10, IL-18, and vascular endothelial growth factor, and decreased biomarkers, such as CCL-11, intercellular adhesion molecule-1, and IL-7.ConclusionsThis is the first study to identify changes in serum biomarkers in patients with sICH after IVT, and found that 6 neuroinflammatory and 3 neuroprotective biomarkers may be associated with brain injury following post-thrombolytic sICH.Clinical Trial Registrationhttps://www.clinicaltrials.gov, identifier: NCT02854592.https://www.frontiersin.org/articles/10.3389/fneur.2022.889746/fullalteplaseintravenous thrombolysissymptomatic intracranial hemorrhagebiomarkersmicroarray analysis |
| spellingShingle | Yu Cui Xin-Hong Wang Yong Zhao Shao-Yuan Chen Bao-Ying Sheng Li-Hua Wang Hui-Sheng Chen Change of Serum Biomarkers to Post-Thrombolytic Symptomatic Intracranial Hemorrhage in Stroke Frontiers in Neurology alteplase intravenous thrombolysis symptomatic intracranial hemorrhage biomarkers microarray analysis |
| title | Change of Serum Biomarkers to Post-Thrombolytic Symptomatic Intracranial Hemorrhage in Stroke |
| title_full | Change of Serum Biomarkers to Post-Thrombolytic Symptomatic Intracranial Hemorrhage in Stroke |
| title_fullStr | Change of Serum Biomarkers to Post-Thrombolytic Symptomatic Intracranial Hemorrhage in Stroke |
| title_full_unstemmed | Change of Serum Biomarkers to Post-Thrombolytic Symptomatic Intracranial Hemorrhage in Stroke |
| title_short | Change of Serum Biomarkers to Post-Thrombolytic Symptomatic Intracranial Hemorrhage in Stroke |
| title_sort | change of serum biomarkers to post thrombolytic symptomatic intracranial hemorrhage in stroke |
| topic | alteplase intravenous thrombolysis symptomatic intracranial hemorrhage biomarkers microarray analysis |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.889746/full |
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