Tzfp represses the androgen receptor in mouse testis.
The testis zinc finger protein (Tzfp), also known as Repressor of GATA, belongs to the BTB/POZ zinc finger family of transcription factors and is thought to play a role in spermatogenesis due to its remarkably high expression in testis. Despite many attempts to find the in vivo role of the protein,...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3636255?pdf=render |
| _version_ | 1818623731402014720 |
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| author | Kari Furu Arne Klungland |
| author_facet | Kari Furu Arne Klungland |
| author_sort | Kari Furu |
| collection | DOAJ |
| description | The testis zinc finger protein (Tzfp), also known as Repressor of GATA, belongs to the BTB/POZ zinc finger family of transcription factors and is thought to play a role in spermatogenesis due to its remarkably high expression in testis. Despite many attempts to find the in vivo role of the protein, the molecular function is still largely unknown. Here, we address this issue using a novel mouse model with a disrupted Tzfp gene. Homozygous Tzfp null mice are born at reduced frequency but appear viable and fertile. Sertoli cells in testes lacking Tzfp display an increase in Androgen Receptor (AR) signaling, and several genes in the testis, including Gata1, Aie1 and Fanc, show increased expression. Our results indicate that Tzfp function as a transcriptional regulator and that loss of the protein leads to alterations in AR signaling and reduced number of apoptotic cells in the testicular tubules. |
| first_indexed | 2024-12-16T18:45:43Z |
| format | Article |
| id | doaj.art-bd579e4eb9714c83a27ce61e841d79c8 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-16T18:45:43Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-bd579e4eb9714c83a27ce61e841d79c82022-12-21T22:20:51ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0184e6231410.1371/journal.pone.0062314Tzfp represses the androgen receptor in mouse testis.Kari FuruArne KlunglandThe testis zinc finger protein (Tzfp), also known as Repressor of GATA, belongs to the BTB/POZ zinc finger family of transcription factors and is thought to play a role in spermatogenesis due to its remarkably high expression in testis. Despite many attempts to find the in vivo role of the protein, the molecular function is still largely unknown. Here, we address this issue using a novel mouse model with a disrupted Tzfp gene. Homozygous Tzfp null mice are born at reduced frequency but appear viable and fertile. Sertoli cells in testes lacking Tzfp display an increase in Androgen Receptor (AR) signaling, and several genes in the testis, including Gata1, Aie1 and Fanc, show increased expression. Our results indicate that Tzfp function as a transcriptional regulator and that loss of the protein leads to alterations in AR signaling and reduced number of apoptotic cells in the testicular tubules.http://europepmc.org/articles/PMC3636255?pdf=render |
| spellingShingle | Kari Furu Arne Klungland Tzfp represses the androgen receptor in mouse testis. PLoS ONE |
| title | Tzfp represses the androgen receptor in mouse testis. |
| title_full | Tzfp represses the androgen receptor in mouse testis. |
| title_fullStr | Tzfp represses the androgen receptor in mouse testis. |
| title_full_unstemmed | Tzfp represses the androgen receptor in mouse testis. |
| title_short | Tzfp represses the androgen receptor in mouse testis. |
| title_sort | tzfp represses the androgen receptor in mouse testis |
| url | http://europepmc.org/articles/PMC3636255?pdf=render |
| work_keys_str_mv | AT karifuru tzfprepressestheandrogenreceptorinmousetestis AT arneklungland tzfprepressestheandrogenreceptorinmousetestis |