Updates on immunological mechanistic insights and targeting of the oral lichen planus microenvironment
Oral lichen planus (OLP) is a chronic immune inflammatory disease that is an oral potentially malignant disorder (OPMD), occurs in the oral mucosa and affects approximately 0.5% to 4% of the general population. There are usually five types of OLP: reticular/papular, plaque-like, atrophic/erythematou...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-01-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1023213/full |
| _version_ | 1797956903652818944 |
|---|---|
| author | Xiaoting Deng Ying Wang Lu Jiang Jing Li Qianming Chen |
| author_facet | Xiaoting Deng Ying Wang Lu Jiang Jing Li Qianming Chen |
| author_sort | Xiaoting Deng |
| collection | DOAJ |
| description | Oral lichen planus (OLP) is a chronic immune inflammatory disease that is an oral potentially malignant disorder (OPMD), occurs in the oral mucosa and affects approximately 0.5% to 4% of the general population. There are usually five types of OLP: reticular/papular, plaque-like, atrophic/erythematous, erosive/ulcerative, and bullous. Furthermore, the chance of causing oral squamous cell carcinoma (OSCC) is 1.4%. Although the etiology of OLP is still unknown, accumulating evidence supports that immune dysregulation may play a vital role in the pathogenesis of OLP, especially the massive production of various inflammatory cells and inflammatory mediators. In this review, we focus on the relationship between OLP and its immune microenvironment. We summarize current developments in the immunology of OLP, summarizing functional cell types and crucial cytokines in the OLP immune microenvironment and the underlying mechanisms of key signaling pathways in the OLP immune microenvironment. We highlight the application potential of targeted immune microenvironment therapy for OLP. |
| first_indexed | 2024-04-10T23:56:00Z |
| format | Article |
| id | doaj.art-bd58dd12947a454aa89e1ad5a103e387 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T23:56:00Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-bd58dd12947a454aa89e1ad5a103e3872023-01-10T13:34:30ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-01-011310.3389/fimmu.2022.10232131023213Updates on immunological mechanistic insights and targeting of the oral lichen planus microenvironmentXiaoting DengYing WangLu JiangJing LiQianming ChenOral lichen planus (OLP) is a chronic immune inflammatory disease that is an oral potentially malignant disorder (OPMD), occurs in the oral mucosa and affects approximately 0.5% to 4% of the general population. There are usually five types of OLP: reticular/papular, plaque-like, atrophic/erythematous, erosive/ulcerative, and bullous. Furthermore, the chance of causing oral squamous cell carcinoma (OSCC) is 1.4%. Although the etiology of OLP is still unknown, accumulating evidence supports that immune dysregulation may play a vital role in the pathogenesis of OLP, especially the massive production of various inflammatory cells and inflammatory mediators. In this review, we focus on the relationship between OLP and its immune microenvironment. We summarize current developments in the immunology of OLP, summarizing functional cell types and crucial cytokines in the OLP immune microenvironment and the underlying mechanisms of key signaling pathways in the OLP immune microenvironment. We highlight the application potential of targeted immune microenvironment therapy for OLP.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1023213/fulloral lichen planusimmune microenvironmentimmune cellschemokineimmune therapy |
| spellingShingle | Xiaoting Deng Ying Wang Lu Jiang Jing Li Qianming Chen Updates on immunological mechanistic insights and targeting of the oral lichen planus microenvironment Frontiers in Immunology oral lichen planus immune microenvironment immune cells chemokine immune therapy |
| title | Updates on immunological mechanistic insights and targeting of the oral lichen planus microenvironment |
| title_full | Updates on immunological mechanistic insights and targeting of the oral lichen planus microenvironment |
| title_fullStr | Updates on immunological mechanistic insights and targeting of the oral lichen planus microenvironment |
| title_full_unstemmed | Updates on immunological mechanistic insights and targeting of the oral lichen planus microenvironment |
| title_short | Updates on immunological mechanistic insights and targeting of the oral lichen planus microenvironment |
| title_sort | updates on immunological mechanistic insights and targeting of the oral lichen planus microenvironment |
| topic | oral lichen planus immune microenvironment immune cells chemokine immune therapy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1023213/full |
| work_keys_str_mv | AT xiaotingdeng updatesonimmunologicalmechanisticinsightsandtargetingoftheorallichenplanusmicroenvironment AT yingwang updatesonimmunologicalmechanisticinsightsandtargetingoftheorallichenplanusmicroenvironment AT lujiang updatesonimmunologicalmechanisticinsightsandtargetingoftheorallichenplanusmicroenvironment AT jingli updatesonimmunologicalmechanisticinsightsandtargetingoftheorallichenplanusmicroenvironment AT qianmingchen updatesonimmunologicalmechanisticinsightsandtargetingoftheorallichenplanusmicroenvironment |