Structures of distantly related interacting protein homologs are less divergent than non‐interacting homologs

Structures of distantly related interacting protein homologs are less divergent than non‐interacting homologs

Homologous proteins can display high structural variation due to evolutionary divergence at low sequence identity. This classical inverse relationship between sequence identity and structural similarity, established many years ago, has remained true between homologous proteins of known structure ove...

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Bibliographic Details
Main Authors: Nagarajan Naveenkumar, Vasam Manjveekar Prabantu, Sneha Vishwanath, Ramanathan Sowdhamini, Narayanaswamy Srinivasan
Format: Article
Language:English
Published: Wiley 2022-12-01
Series:FEBS Open Bio
Subjects:
asymmetry
interacting homologs
protein–protein interaction
sequence identity
structural similarity
Online Access:https://doi.org/10.1002/2211-5463.13492

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