The potential of functionalized dressing releasing flavonoids facilitates scar-free healing
Scars are pathological marks left after an injury heals that inflict physical and psychological harm, especially the great threat to development and aesthetics posed by oral and maxillofacial scars. The differential expression of genes such as transforming growth factor-β, local adherent plaque kina...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.978120/full |
| _version_ | 1811205064693383168 |
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| author | Mengyuan Zhang Mengyuan Zhang Xiaohang Chen Xiaohang Chen Yuan Zhang Yuan Zhang Xiangyu Zhao Xiangyu Zhao Jing Zhao Jing Zhao Xing Wang Xing Wang |
| author_facet | Mengyuan Zhang Mengyuan Zhang Xiaohang Chen Xiaohang Chen Yuan Zhang Yuan Zhang Xiangyu Zhao Xiangyu Zhao Jing Zhao Jing Zhao Xing Wang Xing Wang |
| author_sort | Mengyuan Zhang |
| collection | DOAJ |
| description | Scars are pathological marks left after an injury heals that inflict physical and psychological harm, especially the great threat to development and aesthetics posed by oral and maxillofacial scars. The differential expression of genes such as transforming growth factor-β, local adherent plaque kinase, and yes-related transcriptional regulators at infancy or the oral mucosa is thought to be the reason of scarless regenerative capacity after tissue defects. Currently, tissue engineering products for defect repair frequently overlook the management of postoperative scars, and inhibitors of important genes alone have negative consequences for the organism. Natural flavonoids have hemostatic, anti-inflammatory, antioxidant, and antibacterial properties, which promote wound healing and have anti-scar properties by interfering with the transmission of key signaling pathways involved in scar formation. The combination of flavonoid-rich drug dressings provides a platform for clinical translation of compounds that aid in drug disintegration, prolonged release, and targeted delivery. Therefore, we present a review of the mechanisms and effects of flavonoids in promoting scar-free regeneration and the application of flavonoid-laden dressings. |
| first_indexed | 2024-04-12T03:25:24Z |
| format | Article |
| id | doaj.art-bd59fc90d06a4c59923fd401780dd9ee |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-12T03:25:24Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-bd59fc90d06a4c59923fd401780dd9ee2022-12-22T03:49:45ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-10-01910.3389/fmed.2022.978120978120The potential of functionalized dressing releasing flavonoids facilitates scar-free healingMengyuan Zhang0Mengyuan Zhang1Xiaohang Chen2Xiaohang Chen3Yuan Zhang4Yuan Zhang5Xiangyu Zhao6Xiangyu Zhao7Jing Zhao8Jing Zhao9Xing Wang10Xing Wang11School and Hospital of Stomatology, Shanxi Medical University, Taiyuan, ChinaShanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, ChinaSchool and Hospital of Stomatology, Shanxi Medical University, Taiyuan, ChinaShanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, ChinaSchool and Hospital of Stomatology, Shanxi Medical University, Taiyuan, ChinaShanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, ChinaSchool and Hospital of Stomatology, Shanxi Medical University, Taiyuan, ChinaShanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, ChinaSchool and Hospital of Stomatology, Shanxi Medical University, Taiyuan, ChinaShanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, ChinaSchool and Hospital of Stomatology, Shanxi Medical University, Taiyuan, ChinaShanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, ChinaScars are pathological marks left after an injury heals that inflict physical and psychological harm, especially the great threat to development and aesthetics posed by oral and maxillofacial scars. The differential expression of genes such as transforming growth factor-β, local adherent plaque kinase, and yes-related transcriptional regulators at infancy or the oral mucosa is thought to be the reason of scarless regenerative capacity after tissue defects. Currently, tissue engineering products for defect repair frequently overlook the management of postoperative scars, and inhibitors of important genes alone have negative consequences for the organism. Natural flavonoids have hemostatic, anti-inflammatory, antioxidant, and antibacterial properties, which promote wound healing and have anti-scar properties by interfering with the transmission of key signaling pathways involved in scar formation. The combination of flavonoid-rich drug dressings provides a platform for clinical translation of compounds that aid in drug disintegration, prolonged release, and targeted delivery. Therefore, we present a review of the mechanisms and effects of flavonoids in promoting scar-free regeneration and the application of flavonoid-laden dressings.https://www.frontiersin.org/articles/10.3389/fmed.2022.978120/fullflavonoidsscarless regenerationbiomaterialsdrug deliverydressings |
| spellingShingle | Mengyuan Zhang Mengyuan Zhang Xiaohang Chen Xiaohang Chen Yuan Zhang Yuan Zhang Xiangyu Zhao Xiangyu Zhao Jing Zhao Jing Zhao Xing Wang Xing Wang The potential of functionalized dressing releasing flavonoids facilitates scar-free healing Frontiers in Medicine flavonoids scarless regeneration biomaterials drug delivery dressings |
| title | The potential of functionalized dressing releasing flavonoids facilitates scar-free healing |
| title_full | The potential of functionalized dressing releasing flavonoids facilitates scar-free healing |
| title_fullStr | The potential of functionalized dressing releasing flavonoids facilitates scar-free healing |
| title_full_unstemmed | The potential of functionalized dressing releasing flavonoids facilitates scar-free healing |
| title_short | The potential of functionalized dressing releasing flavonoids facilitates scar-free healing |
| title_sort | potential of functionalized dressing releasing flavonoids facilitates scar free healing |
| topic | flavonoids scarless regeneration biomaterials drug delivery dressings |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.978120/full |
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