Mean platelet volume predicts the glycemic control deterioration in diabetes mellitus type 2 patients
Aim To investigate association of mean platelet volume (MPV) and glycemic control markers, and whether MPV could be used as a predictor of deterioration of glucoregulation in Diabetes mellitus type 2 (DMT2) patients. Methods The cross-sectional study included 106 DMT2 patients, treated at the Prima...
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| Format: | Article |
| Language: | English |
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Medical Association of Zenica-Doboj Canton
2016-02-01
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| Series: | Medicinski Glasnik |
| Subjects: | |
| Online Access: | http://www.ljkzedo.ba/sites/default/files/Glasnik/MG24/10%20Kadic%20843%20A.pdf |
| _version_ | 1818606818694266880 |
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| author | Damira Kadić Sabaheta Hasić Emina Spahić |
| author_facet | Damira Kadić Sabaheta Hasić Emina Spahić |
| author_sort | Damira Kadić |
| collection | DOAJ |
| description | Aim To investigate association of mean platelet volume (MPV) and glycemic control markers, and whether MPV could be used as a predictor of deterioration of glucoregulation in Diabetes mellitus type 2 (DMT2) patients.
Methods The cross-sectional study included 106 DMT2 patients, treated at the Primary Health Care Centre in Zenica, distributed into groups according to glycated haemoglobin (HbA1c) values: A (n=44, HbA1c ≤7.0%) and B (n=62, HbA1c>7.0%). Spearman’s correlation coefficients were calculated to evaluate the relationships between MPV and glycemic control markers. Binomial logisticregression analysis was performed to estimate the relationship between glycemic control, as dichotomous outcome, and MPV as the main predictor. Diagnostic value of MPV as a marker for poor glucoregulation was estimated by using ROC analysis.
Results Mean platelet volume was significantly higher in the group B compared to the group A (p<0.0005). Significant positive correlations of MPV with fasting blood glucose and HbA1c were found in the total sample (rho=0.382, p<0.0005; rho=0.430, p<0.0005, respectively). Mean platelet volume was positively associated with the risk of inadequate glycemic control, with 2 times increased odds of inadequate glycemic control per femtoliter greater MPV (Exp (β) =2.195; 95% CI=1.468 - 3.282, p<0.0005). The area under ROC curve for MPV was 0.726 (95% CI: =0.628-0.823, p <0.0005). At the best cut-off value 9.55 fL, MPV showed sensitivity of 82% and specificity of 54.5%.
Conclusion Mean platelet volume correlates with glycemic control markers in DMT2 patients. It could be used as a simple and cost-effective predictor of deterioration of glucoregulation. |
| first_indexed | 2024-12-16T14:16:54Z |
| format | Article |
| id | doaj.art-bd5acd16b75247eba74ff99a4babc6f2 |
| institution | Directory Open Access Journal |
| issn | 1840-0132 1840-2445 |
| language | English |
| last_indexed | 2024-12-16T14:16:54Z |
| publishDate | 2016-02-01 |
| publisher | Medical Association of Zenica-Doboj Canton |
| record_format | Article |
| series | Medicinski Glasnik |
| spelling | doaj.art-bd5acd16b75247eba74ff99a4babc6f22022-12-21T22:28:35ZengMedical Association of Zenica-Doboj CantonMedicinski Glasnik1840-01321840-24452016-02-011311710.17392/843-16Mean platelet volume predicts the glycemic control deterioration in diabetes mellitus type 2 patientsDamira Kadić0Sabaheta Hasić1Emina Spahić2Department of Laboratory Diagnostics, Cantonal Hospital Zenica, ZenicaDepartment of Medical Biochemistry, School of Medicine, University of Sarajevo, SarajevoPrimary Health Care Centre Zenica, Zenica; Bosnia and HerzegovinaAim To investigate association of mean platelet volume (MPV) and glycemic control markers, and whether MPV could be used as a predictor of deterioration of glucoregulation in Diabetes mellitus type 2 (DMT2) patients. Methods The cross-sectional study included 106 DMT2 patients, treated at the Primary Health Care Centre in Zenica, distributed into groups according to glycated haemoglobin (HbA1c) values: A (n=44, HbA1c ≤7.0%) and B (n=62, HbA1c>7.0%). Spearman’s correlation coefficients were calculated to evaluate the relationships between MPV and glycemic control markers. Binomial logisticregression analysis was performed to estimate the relationship between glycemic control, as dichotomous outcome, and MPV as the main predictor. Diagnostic value of MPV as a marker for poor glucoregulation was estimated by using ROC analysis. Results Mean platelet volume was significantly higher in the group B compared to the group A (p<0.0005). Significant positive correlations of MPV with fasting blood glucose and HbA1c were found in the total sample (rho=0.382, p<0.0005; rho=0.430, p<0.0005, respectively). Mean platelet volume was positively associated with the risk of inadequate glycemic control, with 2 times increased odds of inadequate glycemic control per femtoliter greater MPV (Exp (β) =2.195; 95% CI=1.468 - 3.282, p<0.0005). The area under ROC curve for MPV was 0.726 (95% CI: =0.628-0.823, p <0.0005). At the best cut-off value 9.55 fL, MPV showed sensitivity of 82% and specificity of 54.5%. Conclusion Mean platelet volume correlates with glycemic control markers in DMT2 patients. It could be used as a simple and cost-effective predictor of deterioration of glucoregulation.http://www.ljkzedo.ba/sites/default/files/Glasnik/MG24/10%20Kadic%20843%20A.pdfplatelet activationhemoglobin Aglycosylatedlogistic modelsrisk assessmentROC curve |
| spellingShingle | Damira Kadić Sabaheta Hasić Emina Spahić Mean platelet volume predicts the glycemic control deterioration in diabetes mellitus type 2 patients Medicinski Glasnik platelet activation hemoglobin A glycosylated logistic models risk assessment ROC curve |
| title | Mean platelet volume predicts the glycemic control deterioration in diabetes mellitus type 2 patients |
| title_full | Mean platelet volume predicts the glycemic control deterioration in diabetes mellitus type 2 patients |
| title_fullStr | Mean platelet volume predicts the glycemic control deterioration in diabetes mellitus type 2 patients |
| title_full_unstemmed | Mean platelet volume predicts the glycemic control deterioration in diabetes mellitus type 2 patients |
| title_short | Mean platelet volume predicts the glycemic control deterioration in diabetes mellitus type 2 patients |
| title_sort | mean platelet volume predicts the glycemic control deterioration in diabetes mellitus type 2 patients |
| topic | platelet activation hemoglobin A glycosylated logistic models risk assessment ROC curve |
| url | http://www.ljkzedo.ba/sites/default/files/Glasnik/MG24/10%20Kadic%20843%20A.pdf |
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