Potential herd protection against Plasmodium falciparum infections conferred by mass antimalarial drug administrations
The global malaria burden has decreased over the last decade and many nations are attempting elimination. Asymptomatic malaria infections are not normally diagnosed or treated, posing a major hurdle for elimination efforts. One solution to this problem is mass drug administration (MDA), with success...
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| Language: | English |
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eLife Sciences Publications Ltd
2019-04-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/41023 |
| _version_ | 1811200064530415616 |
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| author | Daniel M Parker Sai Thein Than Tun Lisa J White Ladda Kajeechiwa May Myo Thwin Jordi Landier Victor Chaumeau Vincent Corbel Arjen M Dondorp Lorenz von Seidlein Nicholas J White Richard J Maude François Nosten |
| author_facet | Daniel M Parker Sai Thein Than Tun Lisa J White Ladda Kajeechiwa May Myo Thwin Jordi Landier Victor Chaumeau Vincent Corbel Arjen M Dondorp Lorenz von Seidlein Nicholas J White Richard J Maude François Nosten |
| author_sort | Daniel M Parker |
| collection | DOAJ |
| description | The global malaria burden has decreased over the last decade and many nations are attempting elimination. Asymptomatic malaria infections are not normally diagnosed or treated, posing a major hurdle for elimination efforts. One solution to this problem is mass drug administration (MDA), with success depending on adequate population participation. Here, we present a detailed spatial and temporal analysis of malaria episodes and asymptomatic infections in four villages undergoing MDA in Myanmar. In this study, individuals from neighborhoods with low MDA adherence had 2.85 times the odds of having a malaria episode post-MDA in comparison to those from high adherence neighborhoods, regardless of individual participation, suggesting a herd effect. High mosquito biting rates, living in a house with someone else with malaria, or having an asymptomatic malaria infection were also predictors of clinical episodes. Spatial clustering of non-adherence to MDA, even in villages with high overall participation, may frustrate elimination efforts. |
| first_indexed | 2024-04-12T01:58:24Z |
| format | Article |
| id | doaj.art-bd5b6807eb02449fa7360e6962fbbb3a |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T01:58:24Z |
| publishDate | 2019-04-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-bd5b6807eb02449fa7360e6962fbbb3a2022-12-22T03:52:45ZengeLife Sciences Publications LtdeLife2050-084X2019-04-01810.7554/eLife.41023Potential herd protection against Plasmodium falciparum infections conferred by mass antimalarial drug administrationsDaniel M Parker0https://orcid.org/0000-0002-5352-7338Sai Thein Than Tun1Lisa J White2Ladda Kajeechiwa3May Myo Thwin4Jordi Landier5https://orcid.org/0000-0001-8619-9775Victor Chaumeau6https://orcid.org/0000-0003-0171-2176Vincent Corbel7Arjen M Dondorp8https://orcid.org/0000-0001-5190-2395Lorenz von Seidlein9Nicholas J White10https://orcid.org/0000-0002-1897-1978Richard J Maude11François Nosten12https://orcid.org/0000-0002-7951-0745Department of Population Health and Disease Prevention, University of California, Irvine, United StatesMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Nakhon Pathom, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United kingdomMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Nakhon Pathom, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United kingdomShoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Nakhon Pathom, ThailandShoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Nakhon Pathom, ThailandInstitut de Recherche pour le Développement, University of Montpellier, Montpellier, FranceCentre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United kingdom; Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Nakhon Pathom, Thailand; Centre Hospitalier Universitaire de Montpellier, Montpellier, France; Maladies Infectieuses et Vecteurs, Ecologie, Génétique, Evolution et Contrôle IRD 224-CNRS 5290UM1-UM2, Institut de Recherche pour le Développement (IRD), University of Montpellier, Montpellier, FranceMaladies Infectieuses et Vecteurs, Ecologie, Génétique, Evolution et Contrôle IRD 224-CNRS 5290UM1-UM2, Institut de Recherche pour le Développement (IRD), University of Montpellier, Montpellier, FranceMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Nakhon Pathom, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United kingdomMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Nakhon Pathom, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United kingdomMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Nakhon Pathom, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United kingdomMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Nakhon Pathom, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United kingdom; Harvard TH Chan School of Public Health, Harvard University, Harvard, United StatesCentre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United kingdom; Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Nakhon Pathom, ThailandThe global malaria burden has decreased over the last decade and many nations are attempting elimination. Asymptomatic malaria infections are not normally diagnosed or treated, posing a major hurdle for elimination efforts. One solution to this problem is mass drug administration (MDA), with success depending on adequate population participation. Here, we present a detailed spatial and temporal analysis of malaria episodes and asymptomatic infections in four villages undergoing MDA in Myanmar. In this study, individuals from neighborhoods with low MDA adherence had 2.85 times the odds of having a malaria episode post-MDA in comparison to those from high adherence neighborhoods, regardless of individual participation, suggesting a herd effect. High mosquito biting rates, living in a house with someone else with malaria, or having an asymptomatic malaria infection were also predictors of clinical episodes. Spatial clustering of non-adherence to MDA, even in villages with high overall participation, may frustrate elimination efforts.https://elifesciences.org/articles/41023plasmodiummass drug administrationspatial epidemiologyherd effectelimination |
| spellingShingle | Daniel M Parker Sai Thein Than Tun Lisa J White Ladda Kajeechiwa May Myo Thwin Jordi Landier Victor Chaumeau Vincent Corbel Arjen M Dondorp Lorenz von Seidlein Nicholas J White Richard J Maude François Nosten Potential herd protection against Plasmodium falciparum infections conferred by mass antimalarial drug administrations eLife plasmodium mass drug administration spatial epidemiology herd effect elimination |
| title | Potential herd protection against Plasmodium falciparum infections conferred by mass antimalarial drug administrations |
| title_full | Potential herd protection against Plasmodium falciparum infections conferred by mass antimalarial drug administrations |
| title_fullStr | Potential herd protection against Plasmodium falciparum infections conferred by mass antimalarial drug administrations |
| title_full_unstemmed | Potential herd protection against Plasmodium falciparum infections conferred by mass antimalarial drug administrations |
| title_short | Potential herd protection against Plasmodium falciparum infections conferred by mass antimalarial drug administrations |
| title_sort | potential herd protection against plasmodium falciparum infections conferred by mass antimalarial drug administrations |
| topic | plasmodium mass drug administration spatial epidemiology herd effect elimination |
| url | https://elifesciences.org/articles/41023 |
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