The additive value of diffusion tensor imaging in the determination of perianal fistula activity
Abstract Background Although the activity of the perianal fistula has been evaluated before by MRI in the literature, limited diffusion tensor magnetic resonance imaging (DT-MRI) studies are reported to date. Our study aimed to elucidate the role of DT-MRI in evaluating the activity state of the per...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-05-01
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| Series: | The Egyptian Journal of Radiology and Nuclear Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43055-023-01030-z |
| _version_ | 1797827665669914624 |
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| author | Mohamed Mohsen Mostafa Elmansy Mona A. Gad Mohamed Mostafa Mahmoud Mohammed A. Elhawary |
| author_facet | Mohamed Mohsen Mostafa Elmansy Mona A. Gad Mohamed Mostafa Mahmoud Mohammed A. Elhawary |
| author_sort | Mohamed Mohsen |
| collection | DOAJ |
| description | Abstract Background Although the activity of the perianal fistula has been evaluated before by MRI in the literature, limited diffusion tensor magnetic resonance imaging (DT-MRI) studies are reported to date. Our study aimed to elucidate the role of DT-MRI in evaluating the activity state of the perianal fistula and the prediction of postoperative complications. We reviewed the data of 30 patients diagnosed with perianal fistula and referred them for an MRI diffusion study before the surgical intervention. Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) were calculated for the fistulous area and the normal surrounding puborectalis as a control area. Results According to the presence of pus intraoperatively, patients were allocated into two groups: the active group (10 patients) and the inactive group (20 patients). FA and ADC measurements showed a significant decrease in association with the active disease when measured at the fistula site, and this was not observed in the normal surrounding tissues. The area under the curve (AUC) was 0.985 and 0.730 for the ADC and FA, respectively, when cutoff values of 1 × 10–3 mm2/s and 0.621 were applied, respectively. Adding the FA to the ADC increased the DT-MRI specificity to 95% in the determination of the active fistula. The combination between both FA and ADC increased the AUC to 0.785 with a sensitivity of 73.7% and specificity of 63.6% in the detection of postoperative complications. Conclusions DT-MRI could be used as a reliable diagnostic tool to differentiate patients with active perianal fistula disease from inactive ones and to predict the postoperative outcome. |
| first_indexed | 2024-04-09T12:51:59Z |
| format | Article |
| id | doaj.art-bd5b683524d64e6680774f12c628e07b |
| institution | Directory Open Access Journal |
| issn | 2090-4762 |
| language | English |
| last_indexed | 2024-04-09T12:51:59Z |
| publishDate | 2023-05-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Radiology and Nuclear Medicine |
| spelling | doaj.art-bd5b683524d64e6680774f12c628e07b2023-05-14T11:12:05ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine2090-47622023-05-015411810.1186/s43055-023-01030-zThe additive value of diffusion tensor imaging in the determination of perianal fistula activityMohamed Mohsen0Mostafa Elmansy1Mona A. Gad2Mohamed Mostafa Mahmoud3Mohammed A. Elhawary4Department of Radiology, Faculty of Medicine, Mansoura UniversityDepartment of Radiology, Faculty of Medicine, Mansoura UniversityDepartment of Radiology, Faculty of Medicine, Mansoura UniversityDepartment of General Surgery, Mansoura University Faculty of MedicineDepartment of Radiology, Faculty of Medicine, Mansoura UniversityAbstract Background Although the activity of the perianal fistula has been evaluated before by MRI in the literature, limited diffusion tensor magnetic resonance imaging (DT-MRI) studies are reported to date. Our study aimed to elucidate the role of DT-MRI in evaluating the activity state of the perianal fistula and the prediction of postoperative complications. We reviewed the data of 30 patients diagnosed with perianal fistula and referred them for an MRI diffusion study before the surgical intervention. Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) were calculated for the fistulous area and the normal surrounding puborectalis as a control area. Results According to the presence of pus intraoperatively, patients were allocated into two groups: the active group (10 patients) and the inactive group (20 patients). FA and ADC measurements showed a significant decrease in association with the active disease when measured at the fistula site, and this was not observed in the normal surrounding tissues. The area under the curve (AUC) was 0.985 and 0.730 for the ADC and FA, respectively, when cutoff values of 1 × 10–3 mm2/s and 0.621 were applied, respectively. Adding the FA to the ADC increased the DT-MRI specificity to 95% in the determination of the active fistula. The combination between both FA and ADC increased the AUC to 0.785 with a sensitivity of 73.7% and specificity of 63.6% in the detection of postoperative complications. Conclusions DT-MRI could be used as a reliable diagnostic tool to differentiate patients with active perianal fistula disease from inactive ones and to predict the postoperative outcome.https://doi.org/10.1186/s43055-023-01030-zDiffusion tensor imagingPerianal fistulaActivity |
| spellingShingle | Mohamed Mohsen Mostafa Elmansy Mona A. Gad Mohamed Mostafa Mahmoud Mohammed A. Elhawary The additive value of diffusion tensor imaging in the determination of perianal fistula activity The Egyptian Journal of Radiology and Nuclear Medicine Diffusion tensor imaging Perianal fistula Activity |
| title | The additive value of diffusion tensor imaging in the determination of perianal fistula activity |
| title_full | The additive value of diffusion tensor imaging in the determination of perianal fistula activity |
| title_fullStr | The additive value of diffusion tensor imaging in the determination of perianal fistula activity |
| title_full_unstemmed | The additive value of diffusion tensor imaging in the determination of perianal fistula activity |
| title_short | The additive value of diffusion tensor imaging in the determination of perianal fistula activity |
| title_sort | additive value of diffusion tensor imaging in the determination of perianal fistula activity |
| topic | Diffusion tensor imaging Perianal fistula Activity |
| url | https://doi.org/10.1186/s43055-023-01030-z |
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