The Association Between Oxidative Stress and Depressive Symptom Scores in Elderly Population: A Repeated Panel Study
Objectives Previous epidemiological studies about oxidative stress and depression are limited by hospital-based case-control design, single-time measurements of oxidative stress biomarkers, and the small number of study participants. Therefore, in this study, we analyzed the association between biom...
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| Format: | Article |
| Language: | English |
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Korean Society for Preventive Medicine
2016-09-01
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| Series: | Journal of Preventive Medicine and Public Health |
| Subjects: | |
| Online Access: | http://www.jpmph.org/upload/pdf/jpmph-49-5-260.pdf |
| _version_ | 1811323892901347328 |
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| author | Changwoo Han Youn-Hee Lim Yun-Chul Hong |
| author_facet | Changwoo Han Youn-Hee Lim Yun-Chul Hong |
| author_sort | Changwoo Han |
| collection | DOAJ |
| description | Objectives Previous epidemiological studies about oxidative stress and depression are limited by hospital-based case-control design, single-time measurements of oxidative stress biomarkers, and the small number of study participants. Therefore, in this study, we analyzed the association between biomarker of oxidative stress and depressive symptom scores using repeatedly measured panel data from a community-dwelling elderly population. Methods From 2008 to 2010, a total of 478 elderly participants residing in Seoul, Korea, were evaluated three times. Participants underwent the Korean version of the Short Form Generic Depression Scale (SGDS-K) test for screening depression, and urinary malondialdehyde (MDA) levels were measured as an oxidative stress biomarker. We used a generalized estimating equation with a compound symmetry covariance structure to estimate the effects of oxidative stress on depressive symptom scores. Results A two-fold increase in urinary MDA concentration was significantly associated with a 33.88% (95% confidence interval [CI], 21.59% to 47.42%) increase in total SGDS-K scores. In subgroup analyses by gender, a two-fold increase in urinary MDA concentration was significantly associated with increased SGDS-K scores in both men and women (men: 30.88%; 95% CI, 10.24% to 55.37%; women: 34.77%; 95% CI, 20.09% to 51.25%). In bivariate analysis after an SGDS-K score ≥8 was defined as depression, the third and the fourth urinary MDA quartiles showed a significantly increased odds ratio(OR) of depression compared to the lowest urinary MDA quartile (third quartile OR, 6.51; 95% CI, 1.77 to 24.00; fourth quartile OR, 7.11; 95% CI, 1.99 to 25.42). Conclusions Our study suggests a significant association between oxidative stress and depressive symptoms in the elderly population. |
| first_indexed | 2024-04-13T14:04:41Z |
| format | Article |
| id | doaj.art-bd5f5f70c5464461a958d852fa92ebb3 |
| institution | Directory Open Access Journal |
| issn | 1975-8375 2233-4521 |
| language | English |
| last_indexed | 2024-04-13T14:04:41Z |
| publishDate | 2016-09-01 |
| publisher | Korean Society for Preventive Medicine |
| record_format | Article |
| series | Journal of Preventive Medicine and Public Health |
| spelling | doaj.art-bd5f5f70c5464461a958d852fa92ebb32022-12-22T02:43:57ZengKorean Society for Preventive MedicineJournal of Preventive Medicine and Public Health1975-83752233-45212016-09-0149526027410.3961/jpmph.16.0291883The Association Between Oxidative Stress and Depressive Symptom Scores in Elderly Population: A Repeated Panel StudyChangwoo Han0Youn-Hee Lim1Yun-Chul Hong2 Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, KoreaObjectives Previous epidemiological studies about oxidative stress and depression are limited by hospital-based case-control design, single-time measurements of oxidative stress biomarkers, and the small number of study participants. Therefore, in this study, we analyzed the association between biomarker of oxidative stress and depressive symptom scores using repeatedly measured panel data from a community-dwelling elderly population. Methods From 2008 to 2010, a total of 478 elderly participants residing in Seoul, Korea, were evaluated three times. Participants underwent the Korean version of the Short Form Generic Depression Scale (SGDS-K) test for screening depression, and urinary malondialdehyde (MDA) levels were measured as an oxidative stress biomarker. We used a generalized estimating equation with a compound symmetry covariance structure to estimate the effects of oxidative stress on depressive symptom scores. Results A two-fold increase in urinary MDA concentration was significantly associated with a 33.88% (95% confidence interval [CI], 21.59% to 47.42%) increase in total SGDS-K scores. In subgroup analyses by gender, a two-fold increase in urinary MDA concentration was significantly associated with increased SGDS-K scores in both men and women (men: 30.88%; 95% CI, 10.24% to 55.37%; women: 34.77%; 95% CI, 20.09% to 51.25%). In bivariate analysis after an SGDS-K score ≥8 was defined as depression, the third and the fourth urinary MDA quartiles showed a significantly increased odds ratio(OR) of depression compared to the lowest urinary MDA quartile (third quartile OR, 6.51; 95% CI, 1.77 to 24.00; fourth quartile OR, 7.11; 95% CI, 1.99 to 25.42). Conclusions Our study suggests a significant association between oxidative stress and depressive symptoms in the elderly population.http://www.jpmph.org/upload/pdf/jpmph-49-5-260.pdfDepressionDepressive disorderOxidative stressMalondialdehydeAged |
| spellingShingle | Changwoo Han Youn-Hee Lim Yun-Chul Hong The Association Between Oxidative Stress and Depressive Symptom Scores in Elderly Population: A Repeated Panel Study Journal of Preventive Medicine and Public Health Depression Depressive disorder Oxidative stress Malondialdehyde Aged |
| title | The Association Between Oxidative Stress and Depressive Symptom Scores in Elderly Population: A Repeated Panel Study |
| title_full | The Association Between Oxidative Stress and Depressive Symptom Scores in Elderly Population: A Repeated Panel Study |
| title_fullStr | The Association Between Oxidative Stress and Depressive Symptom Scores in Elderly Population: A Repeated Panel Study |
| title_full_unstemmed | The Association Between Oxidative Stress and Depressive Symptom Scores in Elderly Population: A Repeated Panel Study |
| title_short | The Association Between Oxidative Stress and Depressive Symptom Scores in Elderly Population: A Repeated Panel Study |
| title_sort | association between oxidative stress and depressive symptom scores in elderly population a repeated panel study |
| topic | Depression Depressive disorder Oxidative stress Malondialdehyde Aged |
| url | http://www.jpmph.org/upload/pdf/jpmph-49-5-260.pdf |
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