Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria

Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria

Summary: Circulating memory CD8 T cell trafficking and protective capacity during liver-stage malaria infection remains undefined. We find that effector memory CD8 T cells (Tem) infiltrate the liver within 6 hours after malarial or bacterial infections and mediate pathogen clearance. Tem recruitment...

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Bibliographic Details
Main Authors: Mitchell N. Lefebvre, Fionna A. Surette, Scott M. Anthony, Rahul Vijay, Isaac J. Jensen, Lecia L. Pewe, Lisa S. Hancox, Natalija Van Braeckel-Budimir, Stephanie van de Wall, Stina L. Urban, Madison R. Mix, Samarchith P. Kurup, Vladimir P. Badovinac, Noah S. Butler, John T. Harty
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Cell Reports
Subjects:
malaria
liver-stage immunity
CD8 T cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721014339

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