Mycoplasma infection aggravates cardiac involvements in Kawasaki diseases: a retrospective study
BackgroundMycoplasma pneumoniae (MP) infection serves as a substantial cofactor in Kawasaki disease (KD) among patients. Although the dominant issue triggering KD has recently focused on MP infection, the complete demonstration of the relationship between MP infection and KD remains elusive. This st...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1310134/full |
| _version_ | 1797353622887989248 |
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| author | Guoyan Lu Xing Li Jie Tang Yuxi Jin Yang Wang Kaiyu Zhou Yifei Li |
| author_facet | Guoyan Lu Xing Li Jie Tang Yuxi Jin Yang Wang Kaiyu Zhou Yifei Li |
| author_sort | Guoyan Lu |
| collection | DOAJ |
| description | BackgroundMycoplasma pneumoniae (MP) infection serves as a substantial cofactor in Kawasaki disease (KD) among patients. Although the dominant issue triggering KD has recently focused on MP infection, the complete demonstration of the relationship between MP infection and KD remains elusive. This study endeavors to scrutinize and compare the clinical manifestations and cardiac involvement between MP-triggered KD and non-infection–associated KD.MethodThis retrospective study (2023-039, approved by the Institutional Review Board of West China Second University Hospital of Sichuan University) encompassed 247 consecutive patients diagnosed with KD between June 2017 and December 2022. Patients were categorized into two groups: the MP group (n = 38) and the non-MP group (n = 209). Univariable analysis was utilized to discern differences in clinical features, severity of inflammation, and initial or persistent cardiac complications between the two groups.ResultsThe MP group exhibited a more intricate clinical profile compared with the non-MP group, characterized by prolonged hospital stays, a higher incidence of incomplete KD, and elevated comorbidities. In addition, MP infection correlated with severe hematological disorders, coagulation dysfunction, and myocardial injuries. Our findings revealed that MP infection led to prolonged inflammation after initial treatment with intravenous immunoglobulin. Although initial cardiac assessments failed to discern disparities between the two groups, MP infection notably exacerbated coronary artery aneurysms (CAAs), resulting in sustained dilation.ConclusionsRecognizing MP infection as a significant infectious factor associated with KD is imperative. In patients with KD, MP infection significantly prolongs inflammation and causes hematological disturbances during the initial treatment phase. Moreover, the presence of MP infection exacerbates the progression of CAAs and myocardial injuries during the subacute phase of KD, consequently contributing to the persistence of CAAs. |
| first_indexed | 2024-03-08T13:33:41Z |
| format | Article |
| id | doaj.art-bd5feab5b54d46b88177050e75aca8ff |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-08T13:33:41Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-bd5feab5b54d46b88177050e75aca8ff2024-01-17T04:37:14ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-01-011410.3389/fimmu.2023.13101341310134Mycoplasma infection aggravates cardiac involvements in Kawasaki diseases: a retrospective studyGuoyan LuXing LiJie TangYuxi JinYang WangKaiyu ZhouYifei LiBackgroundMycoplasma pneumoniae (MP) infection serves as a substantial cofactor in Kawasaki disease (KD) among patients. Although the dominant issue triggering KD has recently focused on MP infection, the complete demonstration of the relationship between MP infection and KD remains elusive. This study endeavors to scrutinize and compare the clinical manifestations and cardiac involvement between MP-triggered KD and non-infection–associated KD.MethodThis retrospective study (2023-039, approved by the Institutional Review Board of West China Second University Hospital of Sichuan University) encompassed 247 consecutive patients diagnosed with KD between June 2017 and December 2022. Patients were categorized into two groups: the MP group (n = 38) and the non-MP group (n = 209). Univariable analysis was utilized to discern differences in clinical features, severity of inflammation, and initial or persistent cardiac complications between the two groups.ResultsThe MP group exhibited a more intricate clinical profile compared with the non-MP group, characterized by prolonged hospital stays, a higher incidence of incomplete KD, and elevated comorbidities. In addition, MP infection correlated with severe hematological disorders, coagulation dysfunction, and myocardial injuries. Our findings revealed that MP infection led to prolonged inflammation after initial treatment with intravenous immunoglobulin. Although initial cardiac assessments failed to discern disparities between the two groups, MP infection notably exacerbated coronary artery aneurysms (CAAs), resulting in sustained dilation.ConclusionsRecognizing MP infection as a significant infectious factor associated with KD is imperative. In patients with KD, MP infection significantly prolongs inflammation and causes hematological disturbances during the initial treatment phase. Moreover, the presence of MP infection exacerbates the progression of CAAs and myocardial injuries during the subacute phase of KD, consequently contributing to the persistence of CAAs.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1310134/fullKawasaki diseasemycoplasma pneumoniaeprognosiscoronary artery injuriesinflammation |
| spellingShingle | Guoyan Lu Xing Li Jie Tang Yuxi Jin Yang Wang Kaiyu Zhou Yifei Li Mycoplasma infection aggravates cardiac involvements in Kawasaki diseases: a retrospective study Frontiers in Immunology Kawasaki disease mycoplasma pneumoniae prognosis coronary artery injuries inflammation |
| title | Mycoplasma infection aggravates cardiac involvements in Kawasaki diseases: a retrospective study |
| title_full | Mycoplasma infection aggravates cardiac involvements in Kawasaki diseases: a retrospective study |
| title_fullStr | Mycoplasma infection aggravates cardiac involvements in Kawasaki diseases: a retrospective study |
| title_full_unstemmed | Mycoplasma infection aggravates cardiac involvements in Kawasaki diseases: a retrospective study |
| title_short | Mycoplasma infection aggravates cardiac involvements in Kawasaki diseases: a retrospective study |
| title_sort | mycoplasma infection aggravates cardiac involvements in kawasaki diseases a retrospective study |
| topic | Kawasaki disease mycoplasma pneumoniae prognosis coronary artery injuries inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1310134/full |
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