Contrasting roles of MERS-CoV and SARS-CoV-2 internal proteins in pathogenesis in mice

Contrasting roles of MERS-CoV and SARS-CoV-2 internal proteins in pathogenesis in mice

ABSTRACTBetacoronaviruses encode an internal (I) gene via an alternative reading frame within the nucleocapsid gene, called ORF8b for Middle-East respiratory syndrome coronavirus (MERS-CoV) and ORF9b for severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2. Previous reports sugges...

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Bibliographic Details
Main Authors: Lok-Yin Roy Wong, Abby Odle, Emma Luhmann, Douglas C. Wu, Yiquan Wang, Qi Wen Teo, Celeste Ptak, Alan Sariol, Shea Lowery, Matthias Mack, David K. Meyerholz, Nicholas C. Wu, Lilliana Radoshevich, Stanley Perlman
Format: Article
Language:English
Published: American Society for Microbiology 2023-12-01
Series:mBio
Subjects:
MERS-CoV
pathogenesis
immune response
SARS-CoV-2
Online Access:https://journals.asm.org/doi/10.1128/mbio.02476-23

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