Factors Affecting Recurrence-free Survival in Gastric Gastrointestinal Stromal Tumors: A Single Center Experience
Aim:Gastrointestinal stromal tumors (GISTs) are extremely rare. In this study, we aimed to analyze the factors affecting disease-free survival (DFS) in patients operated for non-metastatic gastric GIST (gGIST).Methods:This was a retrospective analysis of 34 patients with resectable gGIST who were fo...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2020-09-01
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| Series: | Haseki Tıp Bülteni |
| Subjects: | |
| Online Access: |
http://www.hasekidergisi.com/archives/archive-detail/article-preview/factors-affecting-recurrence-free-survival-in-gast/40227
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| Summary: | Aim:Gastrointestinal stromal tumors (GISTs) are extremely rare. In this study, we aimed to analyze the factors affecting disease-free survival (DFS) in patients operated for non-metastatic gastric GIST (gGIST).Methods:This was a retrospective analysis of 34 patients with resectable gGIST who were followed up and treated at the oncology clinic between 2008 and 2019. Patients with metastatic disease and non-gastric disease and those aged <18 years were excluded.Results:Seventeen (50%) patients were male. The median age was 64 years. According to Miettinen Risk Scores, seven patients were (20.6%) in very low-risk group, five (14.7%) in low-risk group, 17 (50%) in moderate-risk group, and five (14.7%) patients were in high-risk group. Adjuvant therapy was given in 11 (32.4%) patients. The 5- and 10-year DFS rates were same as 79.2%. The 5- and 10-year overall survival rates were 90.9% and 85.6%, respectively. In multivariate analysis, presence of necrosis [Hazard rate (HR)=9.5], being in high-risk group (HR=27.2), Ki-67 (HR=1.03), and receiving adjuvant therapy (HR=0.51) were factors affecting DFS.Conclusion:We assume that adjuvant therapy should be given in high-risk patients operated for gGIST in the presence of necrosis and high Ki-67. |
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| ISSN: | 1302-0072 2147-2688 |