Factors Affecting Recurrence-free Survival in Gastric Gastrointestinal Stromal Tumors: A Single Center Experience
Aim:Gastrointestinal stromal tumors (GISTs) are extremely rare. In this study, we aimed to analyze the factors affecting disease-free survival (DFS) in patients operated for non-metastatic gastric GIST (gGIST).Methods:This was a retrospective analysis of 34 patients with resectable gGIST who were fo...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2020-09-01
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| Series: | Haseki Tıp Bülteni |
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http://www.hasekidergisi.com/archives/archive-detail/article-preview/factors-affecting-recurrence-free-survival-in-gast/40227
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| _version_ | 1797913280932478976 |
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| author | Ayşegül Sakin Mehmet Naci Aldemir |
| author_facet | Ayşegül Sakin Mehmet Naci Aldemir |
| author_sort | Ayşegül Sakin |
| collection | DOAJ |
| description | Aim:Gastrointestinal stromal tumors (GISTs) are extremely rare. In this study, we aimed to analyze the factors affecting disease-free survival (DFS) in patients operated for non-metastatic gastric GIST (gGIST).Methods:This was a retrospective analysis of 34 patients with resectable gGIST who were followed up and treated at the oncology clinic between 2008 and 2019. Patients with metastatic disease and non-gastric disease and those aged <18 years were excluded.Results:Seventeen (50%) patients were male. The median age was 64 years. According to Miettinen Risk Scores, seven patients were (20.6%) in very low-risk group, five (14.7%) in low-risk group, 17 (50%) in moderate-risk group, and five (14.7%) patients were in high-risk group. Adjuvant therapy was given in 11 (32.4%) patients. The 5- and 10-year DFS rates were same as 79.2%. The 5- and 10-year overall survival rates were 90.9% and 85.6%, respectively. In multivariate analysis, presence of necrosis [Hazard rate (HR)=9.5], being in high-risk group (HR=27.2), Ki-67 (HR=1.03), and receiving adjuvant therapy (HR=0.51) were factors affecting DFS.Conclusion:We assume that adjuvant therapy should be given in high-risk patients operated for gGIST in the presence of necrosis and high Ki-67. |
| first_indexed | 2024-04-10T12:09:24Z |
| format | Article |
| id | doaj.art-bd63118e88af4714b2399ac279bd4d80 |
| institution | Directory Open Access Journal |
| issn | 1302-0072 2147-2688 |
| language | English |
| last_indexed | 2024-04-10T12:09:24Z |
| publishDate | 2020-09-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Haseki Tıp Bülteni |
| spelling | doaj.art-bd63118e88af4714b2399ac279bd4d802023-02-15T16:16:05ZengGalenos YayineviHaseki Tıp Bülteni1302-00722147-26882020-09-0158432733210.4274/haseki.galenos.2020.615213049054Factors Affecting Recurrence-free Survival in Gastric Gastrointestinal Stromal Tumors: A Single Center ExperienceAyşegül Sakin0Mehmet Naci Aldemir1 Van Eğitim ve Araştırma Hastanesi, İç Hastalıkları Kliniği, Van, Türkiye Yüzüncü Yıl Üniversitesi Tıp Fakültesi, Tıbbi Onkoloji Bilim Dalı, Van, Türkiye Aim:Gastrointestinal stromal tumors (GISTs) are extremely rare. In this study, we aimed to analyze the factors affecting disease-free survival (DFS) in patients operated for non-metastatic gastric GIST (gGIST).Methods:This was a retrospective analysis of 34 patients with resectable gGIST who were followed up and treated at the oncology clinic between 2008 and 2019. Patients with metastatic disease and non-gastric disease and those aged <18 years were excluded.Results:Seventeen (50%) patients were male. The median age was 64 years. According to Miettinen Risk Scores, seven patients were (20.6%) in very low-risk group, five (14.7%) in low-risk group, 17 (50%) in moderate-risk group, and five (14.7%) patients were in high-risk group. Adjuvant therapy was given in 11 (32.4%) patients. The 5- and 10-year DFS rates were same as 79.2%. The 5- and 10-year overall survival rates were 90.9% and 85.6%, respectively. In multivariate analysis, presence of necrosis [Hazard rate (HR)=9.5], being in high-risk group (HR=27.2), Ki-67 (HR=1.03), and receiving adjuvant therapy (HR=0.51) were factors affecting DFS.Conclusion:We assume that adjuvant therapy should be given in high-risk patients operated for gGIST in the presence of necrosis and high Ki-67. http://www.hasekidergisi.com/archives/archive-detail/article-preview/factors-affecting-recurrence-free-survival-in-gast/40227 gastrointestinal stromal tumorgastricadjuvant therapysurvival |
| spellingShingle | Ayşegül Sakin Mehmet Naci Aldemir Factors Affecting Recurrence-free Survival in Gastric Gastrointestinal Stromal Tumors: A Single Center Experience Haseki Tıp Bülteni gastrointestinal stromal tumor gastric adjuvant therapy survival |
| title | Factors Affecting Recurrence-free Survival in Gastric Gastrointestinal Stromal Tumors: A Single Center Experience |
| title_full | Factors Affecting Recurrence-free Survival in Gastric Gastrointestinal Stromal Tumors: A Single Center Experience |
| title_fullStr | Factors Affecting Recurrence-free Survival in Gastric Gastrointestinal Stromal Tumors: A Single Center Experience |
| title_full_unstemmed | Factors Affecting Recurrence-free Survival in Gastric Gastrointestinal Stromal Tumors: A Single Center Experience |
| title_short | Factors Affecting Recurrence-free Survival in Gastric Gastrointestinal Stromal Tumors: A Single Center Experience |
| title_sort | factors affecting recurrence free survival in gastric gastrointestinal stromal tumors a single center experience |
| topic | gastrointestinal stromal tumor gastric adjuvant therapy survival |
| url |
http://www.hasekidergisi.com/archives/archive-detail/article-preview/factors-affecting-recurrence-free-survival-in-gast/40227
|
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