Metabolism of the mother, placenta and fetus in diabetes
Metabolic changes occur due to the effects of placental hormones such as human chorionic gonadotropin and human placental lactogen in normal pregnancies. These effects enable the development of insulin resistance among all pregnant women, significantly pronounced in the third trimester. In pregnanci...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Serbian Medical Society
2023-01-01
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| Series: | Srpski Arhiv za Celokupno Lekarstvo |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0370-8179/2023/0370-81792300012D.pdf |
| _version_ | 1827993698961457152 |
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| author | Dugalić Stefan Todorović Jovana Macura Maja Gutić Bojana Milinčić Miloš Božić Dragana Stojiljković Milica Petronijević Milica de Luka Silvio Pantić Igor Perović Milan Parapid Biljana Gojnić Miroslava |
| author_facet | Dugalić Stefan Todorović Jovana Macura Maja Gutić Bojana Milinčić Miloš Božić Dragana Stojiljković Milica Petronijević Milica de Luka Silvio Pantić Igor Perović Milan Parapid Biljana Gojnić Miroslava |
| author_sort | Dugalić Stefan |
| collection | DOAJ |
| description | Metabolic changes occur due to the effects of placental hormones such as human chorionic gonadotropin and human placental lactogen in normal pregnancies. These effects enable the development of insulin resistance among all pregnant women, significantly pronounced in the third trimester. In pregnancies complicated by pre-gestational or gestational diabetes mellitus, these changes are more intensive as they affect the fetoplacental unit. In pregnancies complicated by diabetes the increased number of placental macrophages leads to the increased production of different cytokines which include leptin, tumor necrosis factor alpha, and interleukins. This review addresses placental vascular changes that lead to adverse pregnancy outcomes, along with the effects of the maternal hyperglycemia and fetal hyperinsulinemia. |
| first_indexed | 2024-04-10T04:29:50Z |
| format | Article |
| id | doaj.art-bd647fcdb33f49b7879e34cdd79c74dc |
| institution | Directory Open Access Journal |
| issn | 0370-8179 2406-0895 |
| language | English |
| last_indexed | 2024-04-10T04:29:50Z |
| publishDate | 2023-01-01 |
| publisher | Serbian Medical Society |
| record_format | Article |
| series | Srpski Arhiv za Celokupno Lekarstvo |
| spelling | doaj.art-bd647fcdb33f49b7879e34cdd79c74dc2023-03-10T08:06:27ZengSerbian Medical SocietySrpski Arhiv za Celokupno Lekarstvo0370-81792406-08952023-01-011511-211611910.2298/SARH221021012D0370-81792300012DMetabolism of the mother, placenta and fetus in diabetesDugalić Stefan0https://orcid.org/0000-0001-5292-0595Todorović Jovana1Macura Maja2https://orcid.org/0000-0002-5924-9199Gutić Bojana3Milinčić Miloš4Božić Dragana5Stojiljković Milica6Petronijević Milica7de Luka Silvio8https://orcid.org/0000-0002-0859-9252Pantić Igor9https://orcid.org/0000-0001-6589-8964Perović Milan10https://orcid.org/0000-0002-9054-6407Parapid Biljana11https://orcid.org/0000-0002-1071-2496Gojnić Miroslava12https://orcid.org/0000-0002-7926-3916University Clinical Centre of Serbia, Clinic for Gynecology and Obstetrics, Belgrade, Serbia + University of Belgrade, Faculty of Medicine, Belgrade, SerbiaUniversity of Belgrade, Faculty of Medicine, Institute of Social Medicine, Belgrade, SerbiaUniversity Clinical Centre of Serbia, Clinic for Gynecology and Obstetrics, Belgrade, Serbia + University of Belgrade, Faculty of Medicine, Belgrade, SerbiaUniversity of Novi Sad, Institute of Oncology of Vojvodina, Clinic for Operative Oncology, Novi Sad, SerbiaUniversity of Belgrade, Faculty of Medicine, Institute of Medical Statics and Informatics, Belgrade, SerbiaUniversity Clinical Centre of Serbia, Clinic for Gynecology and Obstetrics, Belgrade, SerbiaUniversity of Belgrade, Faculty of Medicine, Belgrade, Serbia + University Clinical Centre of Serbia, Clinic for Endocrinology, Diabetes and Metabolic Diseases, Belgrade, SerbiaUniversity of Belgrade, Faculty of Medicine, Belgrade, SerbiaUniversity of Belgrade, Faculty of Medicine, Institute for Medical Pathophysiology, Belgrade, SerbiaUniversity of Belgrade, Faculty of Medicine, Institute of Medical Physiology, Belgrade, SerbiaUniversity of Belgrade, Faculty of Medicine, Belgrade, Serbia + Narodni Front University Clinic for Gynecology and Obstetrics, Belgrade, SerbiaUniversity of Belgrade, Faculty of Medicine, Belgrade, Serbia + University Clinical Centre of Serbia, Division of Cardiology, Belgrade, SerbiaUniversity Clinical Centre of Serbia, Clinic for Gynecology and Obstetrics, Belgrade, Serbia + University of Belgrade, Faculty of Medicine, Belgrade, SerbiaMetabolic changes occur due to the effects of placental hormones such as human chorionic gonadotropin and human placental lactogen in normal pregnancies. These effects enable the development of insulin resistance among all pregnant women, significantly pronounced in the third trimester. In pregnancies complicated by pre-gestational or gestational diabetes mellitus, these changes are more intensive as they affect the fetoplacental unit. In pregnancies complicated by diabetes the increased number of placental macrophages leads to the increased production of different cytokines which include leptin, tumor necrosis factor alpha, and interleukins. This review addresses placental vascular changes that lead to adverse pregnancy outcomes, along with the effects of the maternal hyperglycemia and fetal hyperinsulinemia.http://www.doiserbia.nb.rs/img/doi/0370-8179/2023/0370-81792300012D.pdfpregnancypre-gestational diabetesgestational diabetesinsulin resistanceplacental structural abnormalities |
| spellingShingle | Dugalić Stefan Todorović Jovana Macura Maja Gutić Bojana Milinčić Miloš Božić Dragana Stojiljković Milica Petronijević Milica de Luka Silvio Pantić Igor Perović Milan Parapid Biljana Gojnić Miroslava Metabolism of the mother, placenta and fetus in diabetes Srpski Arhiv za Celokupno Lekarstvo pregnancy pre-gestational diabetes gestational diabetes insulin resistance placental structural abnormalities |
| title | Metabolism of the mother, placenta and fetus in diabetes |
| title_full | Metabolism of the mother, placenta and fetus in diabetes |
| title_fullStr | Metabolism of the mother, placenta and fetus in diabetes |
| title_full_unstemmed | Metabolism of the mother, placenta and fetus in diabetes |
| title_short | Metabolism of the mother, placenta and fetus in diabetes |
| title_sort | metabolism of the mother placenta and fetus in diabetes |
| topic | pregnancy pre-gestational diabetes gestational diabetes insulin resistance placental structural abnormalities |
| url | http://www.doiserbia.nb.rs/img/doi/0370-8179/2023/0370-81792300012D.pdf |
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