Exploring Diallelic Genetic Markers: The HardyWeinberg Package
Testing genetic markers for Hardy-Weinberg equilibrium is an important issue in genetic association studies. The HardyWeinberg package offers the classical tests for equilibrium, functions for power computation and for the simulation of marker data under equilibrium and disequilibrium. Functions for...
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| Format: | Article |
| Language: | English |
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Foundation for Open Access Statistics
2015-03-01
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| Series: | Journal of Statistical Software |
| Online Access: | http://www.jstatsoft.org/index.php/jss/article/view/2240 |
| _version_ | 1817970090351525888 |
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| author | Jan Graffelman |
| author_facet | Jan Graffelman |
| author_sort | Jan Graffelman |
| collection | DOAJ |
| description | Testing genetic markers for Hardy-Weinberg equilibrium is an important issue in genetic association studies. The HardyWeinberg package offers the classical tests for equilibrium, functions for power computation and for the simulation of marker data under equilibrium and disequilibrium. Functions for testing equilibrium in the presence of missing data by using multiple imputation are provided. The package also supplies various graphical tools such as ternary plots with acceptance regions, log-ratio plots and Q-Q plots for exploring the equilibrium status of a large set of diallelic markers. Classical tests for equilibrium and graphical representations for diallelic marker data are reviewed. Several data sets illustrate the use of the package. |
| first_indexed | 2024-04-13T20:29:43Z |
| format | Article |
| id | doaj.art-bd66a8bdf56843229f36b000d95043e8 |
| institution | Directory Open Access Journal |
| issn | 1548-7660 |
| language | English |
| last_indexed | 2024-04-13T20:29:43Z |
| publishDate | 2015-03-01 |
| publisher | Foundation for Open Access Statistics |
| record_format | Article |
| series | Journal of Statistical Software |
| spelling | doaj.art-bd66a8bdf56843229f36b000d95043e82022-12-22T02:31:13ZengFoundation for Open Access StatisticsJournal of Statistical Software1548-76602015-03-0164112310.18637/jss.v064.i03844Exploring Diallelic Genetic Markers: The HardyWeinberg PackageJan GraffelmanTesting genetic markers for Hardy-Weinberg equilibrium is an important issue in genetic association studies. The HardyWeinberg package offers the classical tests for equilibrium, functions for power computation and for the simulation of marker data under equilibrium and disequilibrium. Functions for testing equilibrium in the presence of missing data by using multiple imputation are provided. The package also supplies various graphical tools such as ternary plots with acceptance regions, log-ratio plots and Q-Q plots for exploring the equilibrium status of a large set of diallelic markers. Classical tests for equilibrium and graphical representations for diallelic marker data are reviewed. Several data sets illustrate the use of the package.http://www.jstatsoft.org/index.php/jss/article/view/2240 |
| spellingShingle | Jan Graffelman Exploring Diallelic Genetic Markers: The HardyWeinberg Package Journal of Statistical Software |
| title | Exploring Diallelic Genetic Markers: The HardyWeinberg Package |
| title_full | Exploring Diallelic Genetic Markers: The HardyWeinberg Package |
| title_fullStr | Exploring Diallelic Genetic Markers: The HardyWeinberg Package |
| title_full_unstemmed | Exploring Diallelic Genetic Markers: The HardyWeinberg Package |
| title_short | Exploring Diallelic Genetic Markers: The HardyWeinberg Package |
| title_sort | exploring diallelic genetic markers the hardyweinberg package |
| url | http://www.jstatsoft.org/index.php/jss/article/view/2240 |
| work_keys_str_mv | AT jangraffelman exploringdiallelicgeneticmarkersthehardyweinbergpackage |