Deep Insight of the Pathophysiology of Gestational Diabetes Mellitus
Diabetes mellitus is a severe metabolic disorder, which consistently requires medical care and self-management to restrict complications, such as obesity, kidney damage and cardiovascular diseases. The subtype gestational diabetes mellitus (GDM) occurs during pregnancy, which severely affects both t...
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MDPI AG
2022-08-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/17/2672 |
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| author | Amarish Kumar Sharma Sanjeev Singh Himanshu Singh Deviyani Mahajan Prachetha Kolli Gowtham Mandadapu Bimlesh Kumar Dharmendra Kumar Sudarshan Kumar Manoj Kumar Jena |
| author_facet | Amarish Kumar Sharma Sanjeev Singh Himanshu Singh Deviyani Mahajan Prachetha Kolli Gowtham Mandadapu Bimlesh Kumar Dharmendra Kumar Sudarshan Kumar Manoj Kumar Jena |
| author_sort | Amarish Kumar Sharma |
| collection | DOAJ |
| description | Diabetes mellitus is a severe metabolic disorder, which consistently requires medical care and self-management to restrict complications, such as obesity, kidney damage and cardiovascular diseases. The subtype gestational diabetes mellitus (GDM) occurs during pregnancy, which severely affects both the mother and the growing foetus. Obesity, uncontrolled weight gain and advanced gestational age are the prominent risk factors for GDM, which lead to high rate of perinatal mortality and morbidity. In-depth understanding of the molecular mechanism involved in GDM will help researchers to design drugs for the optimal management of the condition without affecting the mother and foetus. This review article is focused on the molecular mechanism involved in the pathophysiology of GDM and the probable biomarkers, which can be helpful for the early diagnosis of the condition. The early diagnosis of the metabolic disorder, most preferably in first trimester of pregnancy, will lead to its effective long-term management, reducing foetal developmental complications and mortality along with safety measures for the mother. |
| first_indexed | 2024-03-10T01:57:11Z |
| format | Article |
| id | doaj.art-bd68ae5e86e74c25b690934ab7e8c41b |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T01:57:11Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-bd68ae5e86e74c25b690934ab7e8c41b2023-11-23T12:54:58ZengMDPI AGCells2073-44092022-08-011117267210.3390/cells11172672Deep Insight of the Pathophysiology of Gestational Diabetes MellitusAmarish Kumar Sharma0Sanjeev Singh1Himanshu Singh2Deviyani Mahajan3Prachetha Kolli4Gowtham Mandadapu5Bimlesh Kumar6Dharmendra Kumar7Sudarshan Kumar8Manoj Kumar Jena9Department of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara 144411, Punjab, IndiaDepartment of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara 144411, Punjab, IndiaDepartment of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara 144411, Punjab, IndiaDepartment of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara 144411, Punjab, IndiaMicrogen Health Inc., 14225 Sullyfield Cir Suite E, Chantilly, VA 20151, USADevansh Lab Werks, 234 Aquarius Drive, Homewood, AL 35209, USASchool of Pharmaceutical Sciences, Lovely Professional University, Phagwara 144411, Punjab, IndiaAnimal Physiology and Reproduction Division, ICAR-Central Institute for Research on Buffaloes, Hisar 125001, Haryana, IndiaAnimal Biotechnology Centre, ICAR-National Dairy Research Institute, Karnal 132001, Haryana, IndiaDepartment of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara 144411, Punjab, IndiaDiabetes mellitus is a severe metabolic disorder, which consistently requires medical care and self-management to restrict complications, such as obesity, kidney damage and cardiovascular diseases. The subtype gestational diabetes mellitus (GDM) occurs during pregnancy, which severely affects both the mother and the growing foetus. Obesity, uncontrolled weight gain and advanced gestational age are the prominent risk factors for GDM, which lead to high rate of perinatal mortality and morbidity. In-depth understanding of the molecular mechanism involved in GDM will help researchers to design drugs for the optimal management of the condition without affecting the mother and foetus. This review article is focused on the molecular mechanism involved in the pathophysiology of GDM and the probable biomarkers, which can be helpful for the early diagnosis of the condition. The early diagnosis of the metabolic disorder, most preferably in first trimester of pregnancy, will lead to its effective long-term management, reducing foetal developmental complications and mortality along with safety measures for the mother.https://www.mdpi.com/2073-4409/11/17/2672gestational diabetes mellitusVEGFpregnancypathophysiologybiomarker |
| spellingShingle | Amarish Kumar Sharma Sanjeev Singh Himanshu Singh Deviyani Mahajan Prachetha Kolli Gowtham Mandadapu Bimlesh Kumar Dharmendra Kumar Sudarshan Kumar Manoj Kumar Jena Deep Insight of the Pathophysiology of Gestational Diabetes Mellitus Cells gestational diabetes mellitus VEGF pregnancy pathophysiology biomarker |
| title | Deep Insight of the Pathophysiology of Gestational Diabetes Mellitus |
| title_full | Deep Insight of the Pathophysiology of Gestational Diabetes Mellitus |
| title_fullStr | Deep Insight of the Pathophysiology of Gestational Diabetes Mellitus |
| title_full_unstemmed | Deep Insight of the Pathophysiology of Gestational Diabetes Mellitus |
| title_short | Deep Insight of the Pathophysiology of Gestational Diabetes Mellitus |
| title_sort | deep insight of the pathophysiology of gestational diabetes mellitus |
| topic | gestational diabetes mellitus VEGF pregnancy pathophysiology biomarker |
| url | https://www.mdpi.com/2073-4409/11/17/2672 |
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