Prognostic analysis of surgical treatment of Chiari malformation type 1 complicated with syringomyelia
Objective To investigate the risk factors for poor prognosis of patients with Chiari malformation type 1 (CM1) complicated with syringomyelia treated by posterior fossa decompression with duraplasty (PFDD). Methods Forty ⁃ seven patients with CM1 complicated with syringomyelia who underwent PFDD at...
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| Format: | Article |
| Language: | English |
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Tianjin Huanhu Hospital
2021-07-01
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| Series: | Chinese Journal of Contemporary Neurology and Neurosurgery |
| Subjects: | |
| Online Access: | http://www.cjcnn.org/index.php/cjcnn/article/view/2365 |
| _version_ | 1818655780691247104 |
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| author | CAI Yuan⁃kun LI Guo LIU Zheng LIU Kui |
| author_facet | CAI Yuan⁃kun LI Guo LIU Zheng LIU Kui |
| author_sort | CAI Yuan⁃kun |
| collection | DOAJ |
| description | Objective To investigate the risk factors for poor prognosis of patients with Chiari malformation type 1 (CM1) complicated with syringomyelia treated by posterior fossa decompression with duraplasty (PFDD). Methods Forty ⁃ seven patients with CM1 complicated with syringomyelia who underwent PFDD at Zhongnan Hospital of Wuhan University from January 2013 to June 2020 were included. The prognosis was evaluated by the traditional evaluation criteria and Chicago Chiari Outcome Scale (CCOS) at 6 months postoperatively, and univariate and multivariate stepwise Logistic regression analyses were performed to screen for risk factors associated with poor outcome. Results Based on whether the CCOS score was greater than 12, 47 patients were divided into the cured group (n = 21) and uncured group (n = 26). Patients in the uncured group had longer disease duration (t = 4.709, P = 0.000) and greater syringomyelia width (t = 3.074, P = 0.004) than the cured group. Multivariable Logistic regression analysis showed that the long duration of disease (≥ 36 months) was an independent risk factor for poor surgical prognosis of patients after PFDD (OR = 21.948, 95%CI: 3.850-125.117; P = 0.001). Conclusions Long duration of disease is an independent risk factor for poor surgical prognosis in patients with CM1 complicated with syringomyelia treated by PFDD, and early surgical treatment is recommended for the patients with symptomatic CM1 complicated with syringomyelia. |
| first_indexed | 2024-12-17T03:15:08Z |
| format | Article |
| id | doaj.art-bd6a7b0376904041afacd52bee9bd227 |
| institution | Directory Open Access Journal |
| issn | 1672-6731 1672-6731 |
| language | English |
| last_indexed | 2024-12-17T03:15:08Z |
| publishDate | 2021-07-01 |
| publisher | Tianjin Huanhu Hospital |
| record_format | Article |
| series | Chinese Journal of Contemporary Neurology and Neurosurgery |
| spelling | doaj.art-bd6a7b0376904041afacd52bee9bd2272022-12-21T22:05:42ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67311672-67312021-07-01210758158510.3969/j.issn.1672⁃6731.2021.07.009Prognostic analysis of surgical treatment of Chiari malformation type 1 complicated with syringomyeliaCAI Yuan⁃kun0LI Guo1 LIU Zheng2 LIU Kui3Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei, ChinaDepartment of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei, ChinaDepartment of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei, ChinaDepartment of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei, ChinaObjective To investigate the risk factors for poor prognosis of patients with Chiari malformation type 1 (CM1) complicated with syringomyelia treated by posterior fossa decompression with duraplasty (PFDD). Methods Forty ⁃ seven patients with CM1 complicated with syringomyelia who underwent PFDD at Zhongnan Hospital of Wuhan University from January 2013 to June 2020 were included. The prognosis was evaluated by the traditional evaluation criteria and Chicago Chiari Outcome Scale (CCOS) at 6 months postoperatively, and univariate and multivariate stepwise Logistic regression analyses were performed to screen for risk factors associated with poor outcome. Results Based on whether the CCOS score was greater than 12, 47 patients were divided into the cured group (n = 21) and uncured group (n = 26). Patients in the uncured group had longer disease duration (t = 4.709, P = 0.000) and greater syringomyelia width (t = 3.074, P = 0.004) than the cured group. Multivariable Logistic regression analysis showed that the long duration of disease (≥ 36 months) was an independent risk factor for poor surgical prognosis of patients after PFDD (OR = 21.948, 95%CI: 3.850-125.117; P = 0.001). Conclusions Long duration of disease is an independent risk factor for poor surgical prognosis in patients with CM1 complicated with syringomyelia treated by PFDD, and early surgical treatment is recommended for the patients with symptomatic CM1 complicated with syringomyelia.http://www.cjcnn.org/index.php/cjcnn/article/view/2365arnold⁃chiari malformationsyringomyelianeurosurgical proceduresprognosisrisk factorslogistic models |
| spellingShingle | CAI Yuan⁃kun LI Guo LIU Zheng LIU Kui Prognostic analysis of surgical treatment of Chiari malformation type 1 complicated with syringomyelia Chinese Journal of Contemporary Neurology and Neurosurgery arnold⁃chiari malformation syringomyelia neurosurgical procedures prognosis risk factors logistic models |
| title | Prognostic analysis of surgical treatment of Chiari malformation type 1 complicated with syringomyelia |
| title_full | Prognostic analysis of surgical treatment of Chiari malformation type 1 complicated with syringomyelia |
| title_fullStr | Prognostic analysis of surgical treatment of Chiari malformation type 1 complicated with syringomyelia |
| title_full_unstemmed | Prognostic analysis of surgical treatment of Chiari malformation type 1 complicated with syringomyelia |
| title_short | Prognostic analysis of surgical treatment of Chiari malformation type 1 complicated with syringomyelia |
| title_sort | prognostic analysis of surgical treatment of chiari malformation type 1 complicated with syringomyelia |
| topic | arnold⁃chiari malformation syringomyelia neurosurgical procedures prognosis risk factors logistic models |
| url | http://www.cjcnn.org/index.php/cjcnn/article/view/2365 |
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