Treatment of critical-sized calvarial non-union defect via collagen-polyglycolic acid scaffold loading with simvastatin in rabbits
The aim of the present study is to investigate the effects of a sustained-release simvastatin in collagen-polyglycolic acid scaffold on bone formation in the rabbit calvarial critical-sized defect. This study was carried out to examine if maximum bone regeneration with less inflammation would be att...
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| Format: | Article |
| Language: | English |
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Ferdowsi University of Mashhad
2016-06-01
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| Series: | The Iranian Journal of Veterinary Science and Technology |
| Subjects: | |
| Online Access: | https://ijvst.um.ac.ir/article_28594_ea7b61eefef5aa45bc4205321f2c36bd.pdf |
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| author | Hooman Mesgarani Jebrail Movafagh Hossein Nourani Javad Behravan Fatemeh Kalalinia Hossein Kazemi Mehrjerdi |
| author_facet | Hooman Mesgarani Jebrail Movafagh Hossein Nourani Javad Behravan Fatemeh Kalalinia Hossein Kazemi Mehrjerdi |
| author_sort | Hooman Mesgarani |
| collection | DOAJ |
| description | The aim of the present study is to investigate the effects of a sustained-release simvastatin in collagen-polyglycolic acid scaffold on bone formation in the rabbit calvarial critical-sized defect. This study was carried out to examine if maximum bone regeneration with less inflammation would be attained by combining an optimal dose of simvastatin with Collagen-Polyglycolic acid scaffold, which is an osteoconductive biomaterial capable of releasing the drug slowly. To induce critical-sized calvarial defect in the 10 nominated adult New-Zealand rabbits we trephined four holes measured 5-mm-diameter into each head, and filled them with preparations of different doses of simvastatin (0.5 mg, and 1 mg) blended with Collagen-Polyglycolic acid, Scaffold alone or left empty. Five animals were sacrificed after 4 weeks and the rest of them after 8 weeks and examined histologically. Statistical analysis revealed that in the first time frame (the first four weeks), the difference between the control group and the simvastatin 0.5 mg group on one hand and the simvastatin 1 mg group
and the control group on the other hand, there were statistically significant difference between (p < 0.05). In the second time frame (the next four weeks), there were statistically significant differences between the simvastatin 0.5 mg group and the control group, and between the scaffold group and the control group (p |
| first_indexed | 2024-04-11T17:52:27Z |
| format | Article |
| id | doaj.art-bd6ba1350b5245a8bb85295e07a1e268 |
| institution | Directory Open Access Journal |
| issn | 2008-465X 2423-6306 |
| language | English |
| last_indexed | 2024-04-11T17:52:27Z |
| publishDate | 2016-06-01 |
| publisher | Ferdowsi University of Mashhad |
| record_format | Article |
| series | The Iranian Journal of Veterinary Science and Technology |
| spelling | doaj.art-bd6ba1350b5245a8bb85295e07a1e2682022-12-22T04:11:02ZengFerdowsi University of MashhadThe Iranian Journal of Veterinary Science and Technology2008-465X2423-63062016-06-0182101910.22067/veterinary.v8i2.5862328594Treatment of critical-sized calvarial non-union defect via collagen-polyglycolic acid scaffold loading with simvastatin in rabbitsHooman Mesgarani0Jebrail Movafagh1Hossein Nourani2Javad Behravan3Fatemeh Kalalinia4Hossein Kazemi Mehrjerdi5Ferdowsi University of MashhadMashhad University Medical sciencesFerdowsi University of MashhadSchool of PharmacyMashhad University of Medical SciencesFerdowsi University of MashhadThe aim of the present study is to investigate the effects of a sustained-release simvastatin in collagen-polyglycolic acid scaffold on bone formation in the rabbit calvarial critical-sized defect. This study was carried out to examine if maximum bone regeneration with less inflammation would be attained by combining an optimal dose of simvastatin with Collagen-Polyglycolic acid scaffold, which is an osteoconductive biomaterial capable of releasing the drug slowly. To induce critical-sized calvarial defect in the 10 nominated adult New-Zealand rabbits we trephined four holes measured 5-mm-diameter into each head, and filled them with preparations of different doses of simvastatin (0.5 mg, and 1 mg) blended with Collagen-Polyglycolic acid, Scaffold alone or left empty. Five animals were sacrificed after 4 weeks and the rest of them after 8 weeks and examined histologically. Statistical analysis revealed that in the first time frame (the first four weeks), the difference between the control group and the simvastatin 0.5 mg group on one hand and the simvastatin 1 mg group and the control group on the other hand, there were statistically significant difference between (p < 0.05). In the second time frame (the next four weeks), there were statistically significant differences between the simvastatin 0.5 mg group and the control group, and between the scaffold group and the control group (phttps://ijvst.um.ac.ir/article_28594_ea7b61eefef5aa45bc4205321f2c36bd.pdfcollagenpolyglycolic acidbone formationsimvastatinscaffold |
| spellingShingle | Hooman Mesgarani Jebrail Movafagh Hossein Nourani Javad Behravan Fatemeh Kalalinia Hossein Kazemi Mehrjerdi Treatment of critical-sized calvarial non-union defect via collagen-polyglycolic acid scaffold loading with simvastatin in rabbits The Iranian Journal of Veterinary Science and Technology collagen polyglycolic acid bone formation simvastatin scaffold |
| title | Treatment of critical-sized calvarial non-union defect via collagen-polyglycolic acid scaffold loading with simvastatin in rabbits |
| title_full | Treatment of critical-sized calvarial non-union defect via collagen-polyglycolic acid scaffold loading with simvastatin in rabbits |
| title_fullStr | Treatment of critical-sized calvarial non-union defect via collagen-polyglycolic acid scaffold loading with simvastatin in rabbits |
| title_full_unstemmed | Treatment of critical-sized calvarial non-union defect via collagen-polyglycolic acid scaffold loading with simvastatin in rabbits |
| title_short | Treatment of critical-sized calvarial non-union defect via collagen-polyglycolic acid scaffold loading with simvastatin in rabbits |
| title_sort | treatment of critical sized calvarial non union defect via collagen polyglycolic acid scaffold loading with simvastatin in rabbits |
| topic | collagen polyglycolic acid bone formation simvastatin scaffold |
| url | https://ijvst.um.ac.ir/article_28594_ea7b61eefef5aa45bc4205321f2c36bd.pdf |
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