A Simple and Convenient Synthesis of Unlabeled and <sup>13</sup>C-Labeled 3-(3-Hydroxyphenyl)-3-Hydroxypropionic Acid and Its Quantification in Human Urine Samples

A Simple and Convenient Synthesis of Unlabeled and <sup>13</sup>C-Labeled 3-(3-Hydroxyphenyl)-3-Hydroxypropionic Acid and Its Quantification in Human Urine Samples

An improved method to synthesize the highly abundant and biomedically important urinary metabolite 3-(3-hydroxyphenyl)-3-hydroxypropionic acid (HPHPA) is reported. The modified protocol is based on an indium-mediated sonochemical Reformatsky reaction. The synthesis is a simple two-step route as oppo...

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Bibliographic Details
Main Authors:	Yeganeh Khaniani, Matthias Lipfert, Dipanjan Bhattacharyya, Rolando Perez Pineiro, Jiamin Zheng, David S. Wishart
Format:	Article
Language:	English
Published:	MDPI AG 2018-11-01
Series:	Metabolites
Subjects:	HPHPA biomarker isotopic labeling sonication Reformatsky reaction
Online Access:	https://www.mdpi.com/2218-1989/8/4/80

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