IMPROVEMENT OF DISSOLUTION RATE OF INDOMETHACIN FROM FAST DISSOLVING TABLETS
In the current study Indomethacin (IM) fast dissolving tablets (FDTs) were prepared by direct compression technique in order to enhance its dissolution rate. The tablets were formulated using two different approaches; super-disintegration and effervescence. A combination formulation of above app...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Universitas Gadjah Mada
2014-07-01
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| Series: | Indonesian Journal of Pharmacy |
| Subjects: | |
| Online Access: | http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/221 |
| Summary: | In the current study Indomethacin (IM) fast dissolving
tablets (FDTs) were prepared by direct compression technique in
order to enhance its dissolution rate. The tablets were formulated
using two different approaches; super-disintegration and effervescence.
A combination formulation of above approaches was also
developed to further improve its properties. The super-disintegrants
used in the formulae were sodium starch glycolate (Primogel),
cross-povidone (Kollidon) and cross-carmellose (Ac-di-sol). Sodium
bicarbonate and citric acid combination was employed as effervescent
ingredients. The prepared powder mixtures of IM were subjected to
evaluation of various pre-compression parameters and tablets were
evaluated for weight variation, dimension, hardness, friability, drug
content, disintegration, wetting time, uniformity of dispersion, in
vitro drug release and stability studies. The FT-IR spectra shown
there are no interaction between of IM with excipient. The results
of pre-compression studies indicate acceptable flow property for all
the powder mixtures. The data of weight variation, dimension,
hardness, friability, uniformity of dispersion and drug content studies
were within the official limits. The wetting time and disintegration
time decreases considerably with the increase in super-disintegrants
amount. By using the combination approach, the disintegration and
wetting time further decreased. In vitro dissolution studies were
carried out using phosphate buffer pH 6.8 as dissolution medium
for 60min and observed that formulation IF9, among superdisintegration
approach, released highest percentage (97.13±2.09)
of IM. In vitro drug release was highest (98.54±2.89) at 60 min for
formulation IF11, when all the formulations were taken into
consideration. The stability study was performed on the promised
formulation IF11 at 40±2o
C/ 75±5% RH for 3 months and the
results indicated that there were no significant changes in aforesaid
tablet properties. |
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| ISSN: | 2338-9427 2338-9486 |