Dual Function of Par3 in Tumorigenesis
Cell maintenance and the establishment of cell polarity involve complicated interactions among multiple protein complexes as well as the regulation of different signaling pathways. As an important cell polarity protein, Par3 is evolutionarily conserved and involved in tight junction formation as wel...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-07-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.915957/full |
| _version_ | 1811323227238039552 |
|---|---|
| author | Tao Lv Tao Lv Tao Lv Jiashun Xu Hemei Yuan Jianling Wang Xinni Jiang |
| author_facet | Tao Lv Tao Lv Tao Lv Jiashun Xu Hemei Yuan Jianling Wang Xinni Jiang |
| author_sort | Tao Lv |
| collection | DOAJ |
| description | Cell maintenance and the establishment of cell polarity involve complicated interactions among multiple protein complexes as well as the regulation of different signaling pathways. As an important cell polarity protein, Par3 is evolutionarily conserved and involved in tight junction formation as well as tumorigenesis. In this review, we aimed to explore the function of Par3 in tumorigenesis. Research has shown that Par3 exhibits dual functions in human cancers, both tumor-promoting and tumor-suppressive. Here, we focus on the activities of Par3 in different stages and types of tumors, aiming to offer a new perspective on the molecular mechanisms that regulate the functions of Par3 in tumor development. Tumor origin, tumor microenvironment, tumor type, cell density, cell–cell contact, and the synergistic effect of Par3 and other tumor-associated signaling pathways may be important reasons for the dual function of Par3. The important role of Par3 in mammalian tumorigenesis and potential signaling pathways is context dependent. |
| first_indexed | 2024-04-13T13:50:20Z |
| format | Article |
| id | doaj.art-bd6d20fc667942feb0f8a8801179d438 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-13T13:50:20Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-bd6d20fc667942feb0f8a8801179d4382022-12-22T02:44:21ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-07-011210.3389/fonc.2022.915957915957Dual Function of Par3 in TumorigenesisTao Lv0Tao Lv1Tao Lv2Jiashun Xu3Hemei Yuan4Jianling Wang5Xinni Jiang6Centre for Yunnan Plateau Biological Resources Protection and Utilization, College of Biological Resource and Food Engineering, Qujing Normal University, Qujing, ChinaYunnan Engineering Research Center of Fruit Wine, Qujing Normal University, Qujing, ChinaKey Laboratory of Yunnan Province Universities of Qujing Natural History and Early Vertebrate Evolution, College of Biological Resource and Food Engineering, Qujing Normal University, Qujing, ChinaCentre for Yunnan Plateau Biological Resources Protection and Utilization, College of Biological Resource and Food Engineering, Qujing Normal University, Qujing, ChinaCentre for Yunnan Plateau Biological Resources Protection and Utilization, College of Biological Resource and Food Engineering, Qujing Normal University, Qujing, ChinaCollege of Chemistry and Environmental Science, Qujing Normal University, Qujing, ChinaSchool of Biological Sciences and Technology, Chengdu Medical College, Chengdu, ChinaCell maintenance and the establishment of cell polarity involve complicated interactions among multiple protein complexes as well as the regulation of different signaling pathways. As an important cell polarity protein, Par3 is evolutionarily conserved and involved in tight junction formation as well as tumorigenesis. In this review, we aimed to explore the function of Par3 in tumorigenesis. Research has shown that Par3 exhibits dual functions in human cancers, both tumor-promoting and tumor-suppressive. Here, we focus on the activities of Par3 in different stages and types of tumors, aiming to offer a new perspective on the molecular mechanisms that regulate the functions of Par3 in tumor development. Tumor origin, tumor microenvironment, tumor type, cell density, cell–cell contact, and the synergistic effect of Par3 and other tumor-associated signaling pathways may be important reasons for the dual function of Par3. The important role of Par3 in mammalian tumorigenesis and potential signaling pathways is context dependent.https://www.frontiersin.org/articles/10.3389/fonc.2022.915957/fullcell polarityPar3dual functiontumor-promotingtumor-suppressive |
| spellingShingle | Tao Lv Tao Lv Tao Lv Jiashun Xu Hemei Yuan Jianling Wang Xinni Jiang Dual Function of Par3 in Tumorigenesis Frontiers in Oncology cell polarity Par3 dual function tumor-promoting tumor-suppressive |
| title | Dual Function of Par3 in Tumorigenesis |
| title_full | Dual Function of Par3 in Tumorigenesis |
| title_fullStr | Dual Function of Par3 in Tumorigenesis |
| title_full_unstemmed | Dual Function of Par3 in Tumorigenesis |
| title_short | Dual Function of Par3 in Tumorigenesis |
| title_sort | dual function of par3 in tumorigenesis |
| topic | cell polarity Par3 dual function tumor-promoting tumor-suppressive |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.915957/full |
| work_keys_str_mv | AT taolv dualfunctionofpar3intumorigenesis AT taolv dualfunctionofpar3intumorigenesis AT taolv dualfunctionofpar3intumorigenesis AT jiashunxu dualfunctionofpar3intumorigenesis AT hemeiyuan dualfunctionofpar3intumorigenesis AT jianlingwang dualfunctionofpar3intumorigenesis AT xinnijiang dualfunctionofpar3intumorigenesis |