Case Report: IgG multiple myeloma and chronic myeloid leukemia in a single patient [version 2; peer review: 2 approved]
A 58-year-old man presented with recurrence of chronic myeloid leukemia (CML) after complete molecular remission in the setting of non-compliance with imatinib. He was restarted on imatinib and was also noted to have IgG kappa monoclonal gammopathy of undetermined significance (MGUS). The patient re...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2020-09-01
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| Series: | F1000Research |
| Online Access: | https://f1000research.com/articles/9-488/v2 |
| _version_ | 1819210334629527552 |
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| author | Neeraja Swaminathan Sorab Gupta Claudia Dourado |
| author_facet | Neeraja Swaminathan Sorab Gupta Claudia Dourado |
| author_sort | Neeraja Swaminathan |
| collection | DOAJ |
| description | A 58-year-old man presented with recurrence of chronic myeloid leukemia (CML) after complete molecular remission in the setting of non-compliance with imatinib. He was restarted on imatinib and was also noted to have IgG kappa monoclonal gammopathy of undetermined significance (MGUS). The patient re-achieved molecular remission after resumption of imatinib, but his MGUS progressed to smoldering myeloma and he was eventually diagnosed with multiple myeloma (MM) and initiated on treatment for MM with thalidomide, bortezomib and dexamethasone. He has responded well to treatment of the myeloma and continues concurrent maintenance imatinib treatment for CML and is being evaluated for bone marrow transplant. The association of two concurrent hematological malignancies, CML and MM, is very rare and has been infrequently reported in literature. The pathophysiology of this has not yet been fully understood. This case report reviews the various theories to explain this and discusses the potential challenges of simultaneous treatment of MM and CML. |
| first_indexed | 2024-12-23T06:09:32Z |
| format | Article |
| id | doaj.art-bd6e214400ce46e3b76106dc538a550a |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-23T06:09:32Z |
| publishDate | 2020-09-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-bd6e214400ce46e3b76106dc538a550a2022-12-21T17:57:30ZengF1000 Research LtdF1000Research2046-14022020-09-01910.12688/f1000research.24086.228094Case Report: IgG multiple myeloma and chronic myeloid leukemia in a single patient [version 2; peer review: 2 approved]Neeraja Swaminathan0Sorab Gupta1Claudia Dourado2Department of Internal Medicine, Albert Einstein Medical Center, Philadelphia, PA, 19141, USADepartment of Hematology, Albert Einstein Medical Center, Philadelphia, PA, 19141, USADepartment of Hematology, Albert Einstein Medical Center, Philadelphia, PA, 19141, USAA 58-year-old man presented with recurrence of chronic myeloid leukemia (CML) after complete molecular remission in the setting of non-compliance with imatinib. He was restarted on imatinib and was also noted to have IgG kappa monoclonal gammopathy of undetermined significance (MGUS). The patient re-achieved molecular remission after resumption of imatinib, but his MGUS progressed to smoldering myeloma and he was eventually diagnosed with multiple myeloma (MM) and initiated on treatment for MM with thalidomide, bortezomib and dexamethasone. He has responded well to treatment of the myeloma and continues concurrent maintenance imatinib treatment for CML and is being evaluated for bone marrow transplant. The association of two concurrent hematological malignancies, CML and MM, is very rare and has been infrequently reported in literature. The pathophysiology of this has not yet been fully understood. This case report reviews the various theories to explain this and discusses the potential challenges of simultaneous treatment of MM and CML.https://f1000research.com/articles/9-488/v2 |
| spellingShingle | Neeraja Swaminathan Sorab Gupta Claudia Dourado Case Report: IgG multiple myeloma and chronic myeloid leukemia in a single patient [version 2; peer review: 2 approved] F1000Research |
| title | Case Report: IgG multiple myeloma and chronic myeloid leukemia in a single patient [version 2; peer review: 2 approved] |
| title_full | Case Report: IgG multiple myeloma and chronic myeloid leukemia in a single patient [version 2; peer review: 2 approved] |
| title_fullStr | Case Report: IgG multiple myeloma and chronic myeloid leukemia in a single patient [version 2; peer review: 2 approved] |
| title_full_unstemmed | Case Report: IgG multiple myeloma and chronic myeloid leukemia in a single patient [version 2; peer review: 2 approved] |
| title_short | Case Report: IgG multiple myeloma and chronic myeloid leukemia in a single patient [version 2; peer review: 2 approved] |
| title_sort | case report igg multiple myeloma and chronic myeloid leukemia in a single patient version 2 peer review 2 approved |
| url | https://f1000research.com/articles/9-488/v2 |
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