Human Umbilical Cord Mesenchymal Stem Cells for Severe Neurological Sequelae due to Anti--Methyl--Aspartate Receptor Encephalitis: First Case Report
Anti- N -methyl- d -aspartate (NMDA) receptor encephalitis is caused by altered patient immune reactions. This study reports the first patient with severe neurologic sequelae after NMDA receptor encephalitis treated with allogeneic umbilical cord–derived mesenchymal stem/stromal cells (UC-MSCs). A 5...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-07-01
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| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.1177/09636897221110876 |
| _version_ | 1818488919903174656 |
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| author | Liem Nguyen Thanh Van T. Hoang Huong Le Thu Phuong Anh Thi Nguyen Duc M. Hoang Doan Van Ngo Hung Cao Vu Van Nguyen Thi Bich Michael Heke |
| author_facet | Liem Nguyen Thanh Van T. Hoang Huong Le Thu Phuong Anh Thi Nguyen Duc M. Hoang Doan Van Ngo Hung Cao Vu Van Nguyen Thi Bich Michael Heke |
| author_sort | Liem Nguyen Thanh |
| collection | DOAJ |
| description | Anti- N -methyl- d -aspartate (NMDA) receptor encephalitis is caused by altered patient immune reactions. This study reports the first patient with severe neurologic sequelae after NMDA receptor encephalitis treated with allogeneic umbilical cord–derived mesenchymal stem/stromal cells (UC-MSCs). A 5-year-old girl was diagnosed with NMDA receptor encephalitis and treated with immunosuppressive medicaments and intravenous immunoglobulin (IVIG). Despite intensive therapy, the patient’s condition worsened so that allogenic UC-MSC therapy was contemplated. The patient received three intrathecal infusions of xeno- and serum-free cultured UC-MSCs at a dose of 10 6 cells/kg. At baseline and after each UC-MSC administration, the patient was examined by the German Coma Recovery Scale (CRS), the Gross Motor Function Classification System (GMFCS), the Gross Motor Function Measure–88 (GMFM-88), the Manual Ability Classification System (MACS), the Modified Ashworth Scale, and the Denver II test. Before cell therapy, she was in a permanent vegetative state with diffuse cerebral atrophy. Her cognition and motor functions improved progressively after three UC-MSC infusions. At the last visit, she was capable of walking, writing, and counting numbers. Control of urinary and bowel functions was completely recovered. Cerebral atrophy was reduced on brain magnetic resonance imaging (MRI). Overall, the outcomes of this patient suggest a potential cell therapy for autoimmune encephalitis and its neurological consequences. |
| first_indexed | 2024-12-10T16:57:18Z |
| format | Article |
| id | doaj.art-bd6e645e65b84d0eb274b43f6f5071ab |
| institution | Directory Open Access Journal |
| issn | 1555-3892 |
| language | English |
| last_indexed | 2024-12-10T16:57:18Z |
| publishDate | 2022-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cell Transplantation |
| spelling | doaj.art-bd6e645e65b84d0eb274b43f6f5071ab2022-12-22T01:40:41ZengSAGE PublishingCell Transplantation1555-38922022-07-013110.1177/09636897221110876Human Umbilical Cord Mesenchymal Stem Cells for Severe Neurological Sequelae due to Anti--Methyl--Aspartate Receptor Encephalitis: First Case ReportLiem Nguyen Thanh0Van T. Hoang1Huong Le Thu2Phuong Anh Thi Nguyen3Duc M. Hoang4Doan Van Ngo5Hung Cao Vu6Van Nguyen Thi Bich7Michael Heke8College of Health Science, VinUniversity, Hanoi, VietnamVinmec Research Institute of Stem Cell and Gene Technology, Vinmec Health Care System, Hanoi, VietnamVinmec International Hospital, Hanoi, VietnamVinmec International Hospital, Hanoi, VietnamVinmec Research Institute of Stem Cell and Gene Technology, Vinmec Health Care System, Hanoi, VietnamVinmec International Hospital, Hanoi, VietnamVietnam National Children’s Hospital, Hanoi, VietnamVietnam National Children’s Hospital, Hanoi, VietnamDepartment of Biology, Stanford University, Stanford, CA, USAAnti- N -methyl- d -aspartate (NMDA) receptor encephalitis is caused by altered patient immune reactions. This study reports the first patient with severe neurologic sequelae after NMDA receptor encephalitis treated with allogeneic umbilical cord–derived mesenchymal stem/stromal cells (UC-MSCs). A 5-year-old girl was diagnosed with NMDA receptor encephalitis and treated with immunosuppressive medicaments and intravenous immunoglobulin (IVIG). Despite intensive therapy, the patient’s condition worsened so that allogenic UC-MSC therapy was contemplated. The patient received three intrathecal infusions of xeno- and serum-free cultured UC-MSCs at a dose of 10 6 cells/kg. At baseline and after each UC-MSC administration, the patient was examined by the German Coma Recovery Scale (CRS), the Gross Motor Function Classification System (GMFCS), the Gross Motor Function Measure–88 (GMFM-88), the Manual Ability Classification System (MACS), the Modified Ashworth Scale, and the Denver II test. Before cell therapy, she was in a permanent vegetative state with diffuse cerebral atrophy. Her cognition and motor functions improved progressively after three UC-MSC infusions. At the last visit, she was capable of walking, writing, and counting numbers. Control of urinary and bowel functions was completely recovered. Cerebral atrophy was reduced on brain magnetic resonance imaging (MRI). Overall, the outcomes of this patient suggest a potential cell therapy for autoimmune encephalitis and its neurological consequences.https://doi.org/10.1177/09636897221110876 |
| spellingShingle | Liem Nguyen Thanh Van T. Hoang Huong Le Thu Phuong Anh Thi Nguyen Duc M. Hoang Doan Van Ngo Hung Cao Vu Van Nguyen Thi Bich Michael Heke Human Umbilical Cord Mesenchymal Stem Cells for Severe Neurological Sequelae due to Anti--Methyl--Aspartate Receptor Encephalitis: First Case Report Cell Transplantation |
| title | Human Umbilical Cord Mesenchymal Stem Cells for Severe Neurological Sequelae due to Anti--Methyl--Aspartate Receptor Encephalitis: First Case Report |
| title_full | Human Umbilical Cord Mesenchymal Stem Cells for Severe Neurological Sequelae due to Anti--Methyl--Aspartate Receptor Encephalitis: First Case Report |
| title_fullStr | Human Umbilical Cord Mesenchymal Stem Cells for Severe Neurological Sequelae due to Anti--Methyl--Aspartate Receptor Encephalitis: First Case Report |
| title_full_unstemmed | Human Umbilical Cord Mesenchymal Stem Cells for Severe Neurological Sequelae due to Anti--Methyl--Aspartate Receptor Encephalitis: First Case Report |
| title_short | Human Umbilical Cord Mesenchymal Stem Cells for Severe Neurological Sequelae due to Anti--Methyl--Aspartate Receptor Encephalitis: First Case Report |
| title_sort | human umbilical cord mesenchymal stem cells for severe neurological sequelae due to anti methyl aspartate receptor encephalitis first case report |
| url | https://doi.org/10.1177/09636897221110876 |
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