Effect of Omega-3 Polyunsaturated Fatty Acids Supplementation on Body Composition and Circulating Levels of Follistatin-Like 1 in Males With Coronary Artery Disease: A Randomized Double-Blind Clinical Trial
Adipokines are mediators of body composition and are involved in obesity-related complications such as cardiovascular disease. Omega-3 supplementation has not been studied in the setting of body composition and follistatin-like 1 (FSTL1) levels in patients with coronary artery disease (CAD). This st...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2017-11-01
|
| Series: | American Journal of Men's Health |
| Online Access: | https://doi.org/10.1177/1557988317720581 |
| _version_ | 1811214478907277312 |
|---|---|
| author | Shirin Jafari Salim Shahab Alizadeh Mahmoud Djalali Ebrahim Nematipour Mohammad Hassan Javanbakht |
| author_facet | Shirin Jafari Salim Shahab Alizadeh Mahmoud Djalali Ebrahim Nematipour Mohammad Hassan Javanbakht |
| author_sort | Shirin Jafari Salim |
| collection | DOAJ |
| description | Adipokines are mediators of body composition and are involved in obesity-related complications such as cardiovascular disease. Omega-3 supplementation has not been studied in the setting of body composition and follistatin-like 1 (FSTL1) levels in patients with coronary artery disease (CAD). This study aimed to investigate the effect of omega-3 polyunsaturated fatty acid (ω-3 PUFA) supplementation on body composition indices and serum levels of FSTL1 in CAD patients. A total of 42 male (aged 45–65 years) subjects with angiographically confirmed CAD were included in this randomized, double-blind, placebo-controlled trial study. The subjects were randomly divided into omega-3 and placebo groups. During the 8-week intervention, the omega-3 group received 1,200 mg of omega-3 daily, while the placebo group received paraffin. Before and after the study, anthropometric measurements and body composition components were taken; serum FSTL1 levels were assessed by an enzyme-linked immunosorbent assay (ELISA) kit. In the omega-3 group, a significant 27.6% increase in serum FSTL1 was seen after 8 weeks of intervention ( p = .001), but no significant difference in posttreatment levels of FSTL1 was observed between the two groups ( p > .05). At the end of the study, a significant decrease in low-density lipoprotein cholesterol (LDL-C; 94.29 ± 22.04 vs. 112.24 ± 24.5; p = .01) and high-sensitivity C-reactive protein (hs-CRP; 1.92 ± 0.79 vs. 3.19 ± 2.51; p = .03) concentration was detected between the two groups. Changes in fasting blood sugar, fasting insulin, body composition, and anthropometric parameters were not significant within and between the groups. Oral omega-3 might increase FSTL1 and decrease LDL-C and hs-CRP concentrations in CAD patients. However, omega-3 supplementation did not have any effect on FSTL1 levels between the groups. |
| first_indexed | 2024-04-12T06:04:19Z |
| format | Article |
| id | doaj.art-bd6f7c7a01cd4fa98b7522a4cf4d0d96 |
| institution | Directory Open Access Journal |
| issn | 1557-9883 1557-9891 |
| language | English |
| last_indexed | 2024-04-12T06:04:19Z |
| publishDate | 2017-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | American Journal of Men's Health |
| spelling | doaj.art-bd6f7c7a01cd4fa98b7522a4cf4d0d962022-12-22T03:44:56ZengSAGE PublishingAmerican Journal of Men's Health1557-98831557-98912017-11-011110.1177/1557988317720581Effect of Omega-3 Polyunsaturated Fatty Acids Supplementation on Body Composition and Circulating Levels of Follistatin-Like 1 in Males With Coronary Artery Disease: A Randomized Double-Blind Clinical TrialShirin Jafari Salim0Shahab Alizadeh1Mahmoud Djalali2Ebrahim Nematipour3Mohammad Hassan Javanbakht4Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, IranDepartment of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, IranDepartment of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, IranDepartment of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences (TUMS), Tehran, IranDepartment of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, IranAdipokines are mediators of body composition and are involved in obesity-related complications such as cardiovascular disease. Omega-3 supplementation has not been studied in the setting of body composition and follistatin-like 1 (FSTL1) levels in patients with coronary artery disease (CAD). This study aimed to investigate the effect of omega-3 polyunsaturated fatty acid (ω-3 PUFA) supplementation on body composition indices and serum levels of FSTL1 in CAD patients. A total of 42 male (aged 45–65 years) subjects with angiographically confirmed CAD were included in this randomized, double-blind, placebo-controlled trial study. The subjects were randomly divided into omega-3 and placebo groups. During the 8-week intervention, the omega-3 group received 1,200 mg of omega-3 daily, while the placebo group received paraffin. Before and after the study, anthropometric measurements and body composition components were taken; serum FSTL1 levels were assessed by an enzyme-linked immunosorbent assay (ELISA) kit. In the omega-3 group, a significant 27.6% increase in serum FSTL1 was seen after 8 weeks of intervention ( p = .001), but no significant difference in posttreatment levels of FSTL1 was observed between the two groups ( p > .05). At the end of the study, a significant decrease in low-density lipoprotein cholesterol (LDL-C; 94.29 ± 22.04 vs. 112.24 ± 24.5; p = .01) and high-sensitivity C-reactive protein (hs-CRP; 1.92 ± 0.79 vs. 3.19 ± 2.51; p = .03) concentration was detected between the two groups. Changes in fasting blood sugar, fasting insulin, body composition, and anthropometric parameters were not significant within and between the groups. Oral omega-3 might increase FSTL1 and decrease LDL-C and hs-CRP concentrations in CAD patients. However, omega-3 supplementation did not have any effect on FSTL1 levels between the groups.https://doi.org/10.1177/1557988317720581 |
| spellingShingle | Shirin Jafari Salim Shahab Alizadeh Mahmoud Djalali Ebrahim Nematipour Mohammad Hassan Javanbakht Effect of Omega-3 Polyunsaturated Fatty Acids Supplementation on Body Composition and Circulating Levels of Follistatin-Like 1 in Males With Coronary Artery Disease: A Randomized Double-Blind Clinical Trial American Journal of Men's Health |
| title | Effect of Omega-3 Polyunsaturated Fatty Acids Supplementation on Body Composition and Circulating Levels of Follistatin-Like 1 in Males With Coronary Artery Disease: A Randomized Double-Blind Clinical Trial |
| title_full | Effect of Omega-3 Polyunsaturated Fatty Acids Supplementation on Body Composition and Circulating Levels of Follistatin-Like 1 in Males With Coronary Artery Disease: A Randomized Double-Blind Clinical Trial |
| title_fullStr | Effect of Omega-3 Polyunsaturated Fatty Acids Supplementation on Body Composition and Circulating Levels of Follistatin-Like 1 in Males With Coronary Artery Disease: A Randomized Double-Blind Clinical Trial |
| title_full_unstemmed | Effect of Omega-3 Polyunsaturated Fatty Acids Supplementation on Body Composition and Circulating Levels of Follistatin-Like 1 in Males With Coronary Artery Disease: A Randomized Double-Blind Clinical Trial |
| title_short | Effect of Omega-3 Polyunsaturated Fatty Acids Supplementation on Body Composition and Circulating Levels of Follistatin-Like 1 in Males With Coronary Artery Disease: A Randomized Double-Blind Clinical Trial |
| title_sort | effect of omega 3 polyunsaturated fatty acids supplementation on body composition and circulating levels of follistatin like 1 in males with coronary artery disease a randomized double blind clinical trial |
| url | https://doi.org/10.1177/1557988317720581 |
| work_keys_str_mv | AT shirinjafarisalim effectofomega3polyunsaturatedfattyacidssupplementationonbodycompositionandcirculatinglevelsoffollistatinlike1inmaleswithcoronaryarterydiseasearandomizeddoubleblindclinicaltrial AT shahabalizadeh effectofomega3polyunsaturatedfattyacidssupplementationonbodycompositionandcirculatinglevelsoffollistatinlike1inmaleswithcoronaryarterydiseasearandomizeddoubleblindclinicaltrial AT mahmouddjalali effectofomega3polyunsaturatedfattyacidssupplementationonbodycompositionandcirculatinglevelsoffollistatinlike1inmaleswithcoronaryarterydiseasearandomizeddoubleblindclinicaltrial AT ebrahimnematipour effectofomega3polyunsaturatedfattyacidssupplementationonbodycompositionandcirculatinglevelsoffollistatinlike1inmaleswithcoronaryarterydiseasearandomizeddoubleblindclinicaltrial AT mohammadhassanjavanbakht effectofomega3polyunsaturatedfattyacidssupplementationonbodycompositionandcirculatinglevelsoffollistatinlike1inmaleswithcoronaryarterydiseasearandomizeddoubleblindclinicaltrial |