The Effects of Riluzole on Cisplatin-induced Ototoxicity
Abstract Introduction Riluzole (2-amino-6-trifluoromethoxy benzothiazole) is known as a neuroprotective, antioxidant, antiapoptotic agent. It may have beneficial effects on neuronal cell death due to cisplatin-induced ototoxicity. Objective To evaluate the effect of riluzol...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações Ltda.
2019-03-01
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| Series: | International Archives of Otorhinolaryngology |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1676654 |
| _version_ | 1818354881271955456 |
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| author | Selin Üstün Bezgin Kadir Kemal Uygur Çağıl Gökdoğan Çiğdem Elmas Güleser Göktaş |
| author_facet | Selin Üstün Bezgin Kadir Kemal Uygur Çağıl Gökdoğan Çiğdem Elmas Güleser Göktaş |
| author_sort | Selin Üstün Bezgin |
| collection | DOAJ |
| description | Abstract
Introduction Riluzole (2-amino-6-trifluoromethoxy benzothiazole) is known as a neuroprotective, antioxidant, antiapoptotic agent. It may have beneficial effects on neuronal cell death due to cisplatin-induced ototoxicity.
Objective To evaluate the effect of riluzole on cisplatin-induced ototoxicity in guinea pigs.
Methods Twenty-four guinea pigs, studied in three groups, underwent auditory brainstem response evaluation using click and 8 kHz tone burst stimuli. Subsequently, 5 mg/kg of cisplatin were administered to all animals for 3 days intraperitoneally (i.p.) to induce ototoxicity. Half an hour prior to cisplatin, groups 1, 2 and 3 received 2 ml of saline i.p., 6 mg/kg of riluzole hydrochloride i.p., and 8 mg/kg of riluzole hydrochloride i.p., respectively, for 3 days. The auditory brainstem responses were repeated 24 hours after the last drug administration. The cochleae were analyzed by transmission electron microscopy (TEM).
Results After drug administiration, for 8,000 Hz stimulus, group 1 had significantly higher threshold shifts when compared with groups 2 (p < 0.05) and 3 (p < 0.05), and there was no significant difference in threshold shifts between groups 2 and 3 (p > 0.05). Transmission electron microscopy findings demonstrated the protective effect of riluzole on the hair cells and the stria vascularis, especially in the group treated with 8 mg/kg of riluzole hydrochloride.
Conclusion We can say that riluzole may have a protective effect on cisplatin- induced ototoxicity. However, additional studies are needed to confirm these results and the mechanisms of action of riluzole. |
| first_indexed | 2024-12-13T19:32:28Z |
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| id | doaj.art-bd72324b036540dfa0bacd8caa209bd4 |
| institution | Directory Open Access Journal |
| issn | 1809-9777 1809-4864 |
| language | English |
| last_indexed | 2024-12-13T19:32:28Z |
| publishDate | 2019-03-01 |
| publisher | Thieme Revinter Publicações Ltda. |
| record_format | Article |
| series | International Archives of Otorhinolaryngology |
| spelling | doaj.art-bd72324b036540dfa0bacd8caa209bd42022-12-21T23:33:54ZengThieme Revinter Publicações Ltda.International Archives of Otorhinolaryngology1809-97771809-48642019-03-012303e267e27510.1055/s-0038-1676654The Effects of Riluzole on Cisplatin-induced OtotoxicitySelin Üstün Bezgin0Kadir Kemal Uygur1Çağıl Gökdoğan2Çiğdem Elmas3Güleser Göktaş4Department of Otorhinolaryngology, Kanuni Sultan Süleyman Education and Research Hospital, İstanbul, TurkeyDepartment of Otorhinolaryngology, Gazi University Faculty of Medicine, Ankara, TurkeyDepartment of Otorhinolaryngology, Muğla Sıtkı Koçman University Faculty of Medicine, Muğla, TurkeyDepartment of Histology and Embryology, Gazi University Faculty of Medicine, Ankara, TurkeyDepartment of Histology and Embryology, Lokman Hekim University, Faculty of Medicine, Ankara, TurkeyAbstract Introduction Riluzole (2-amino-6-trifluoromethoxy benzothiazole) is known as a neuroprotective, antioxidant, antiapoptotic agent. It may have beneficial effects on neuronal cell death due to cisplatin-induced ototoxicity. Objective To evaluate the effect of riluzole on cisplatin-induced ototoxicity in guinea pigs. Methods Twenty-four guinea pigs, studied in three groups, underwent auditory brainstem response evaluation using click and 8 kHz tone burst stimuli. Subsequently, 5 mg/kg of cisplatin were administered to all animals for 3 days intraperitoneally (i.p.) to induce ototoxicity. Half an hour prior to cisplatin, groups 1, 2 and 3 received 2 ml of saline i.p., 6 mg/kg of riluzole hydrochloride i.p., and 8 mg/kg of riluzole hydrochloride i.p., respectively, for 3 days. The auditory brainstem responses were repeated 24 hours after the last drug administration. The cochleae were analyzed by transmission electron microscopy (TEM). Results After drug administiration, for 8,000 Hz stimulus, group 1 had significantly higher threshold shifts when compared with groups 2 (p < 0.05) and 3 (p < 0.05), and there was no significant difference in threshold shifts between groups 2 and 3 (p > 0.05). Transmission electron microscopy findings demonstrated the protective effect of riluzole on the hair cells and the stria vascularis, especially in the group treated with 8 mg/kg of riluzole hydrochloride. Conclusion We can say that riluzole may have a protective effect on cisplatin- induced ototoxicity. However, additional studies are needed to confirm these results and the mechanisms of action of riluzole.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1676654riluzolecisplatinototoxicityauditory brainstem responsetransmission electron microscopy |
| spellingShingle | Selin Üstün Bezgin Kadir Kemal Uygur Çağıl Gökdoğan Çiğdem Elmas Güleser Göktaş The Effects of Riluzole on Cisplatin-induced Ototoxicity International Archives of Otorhinolaryngology riluzole cisplatin ototoxicity auditory brainstem response transmission electron microscopy |
| title | The Effects of Riluzole on Cisplatin-induced Ototoxicity |
| title_full | The Effects of Riluzole on Cisplatin-induced Ototoxicity |
| title_fullStr | The Effects of Riluzole on Cisplatin-induced Ototoxicity |
| title_full_unstemmed | The Effects of Riluzole on Cisplatin-induced Ototoxicity |
| title_short | The Effects of Riluzole on Cisplatin-induced Ototoxicity |
| title_sort | effects of riluzole on cisplatin induced ototoxicity |
| topic | riluzole cisplatin ototoxicity auditory brainstem response transmission electron microscopy |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1676654 |
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