Unprescribed and unnoticed: Retrospective chart review of adverse events of interactions between antidepressants and over-the-counter drugs
Aim: To systematically evaluate prevalence and clinical characteristics of adverse effects of antidepressants and OTC drugs interactions in a retrospective chart review.Methodology: Dataset of 1,145 registered adverse events were evaluated. Reports were selected for further analysis if pharmacoepide...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-08-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.965432/full |
| _version_ | 1798037197820002304 |
|---|---|
| author | Jarosław Woroń Jarosław Woroń Jarosław Woroń Adrian Andrzej Chrobak Daniel Ślęzak Marcin Siwek |
| author_facet | Jarosław Woroń Jarosław Woroń Jarosław Woroń Adrian Andrzej Chrobak Daniel Ślęzak Marcin Siwek |
| author_sort | Jarosław Woroń |
| collection | DOAJ |
| description | Aim: To systematically evaluate prevalence and clinical characteristics of adverse effects of antidepressants and OTC drugs interactions in a retrospective chart review.Methodology: Dataset of 1,145 registered adverse events were evaluated. Reports were selected for further analysis if pharmacoepidemiological avaluation indicated the presence of high probability of a causal relationship between antidepressants and OTC interaction and the occurrence of side effect. Following variables were extracted from the records: sex, age, medical comorbidities, antidepressant and other concomitant medications, clinical consequences ant the possible interaction mechanisms.Results: 368 showed causal relationship with the simultaneous use of antidepressant with another drug. 15 adverse events (4%) were related to the use of OTC medicine, particularly omeprazole, diphenhydramine, Japanese ginkgo biloba, ibuprofen, diclofenac and sildenafil. All of the analysed side effects were categorized as the result of pharmacokinetic interactions. Here we report identified OTC drugs with corresponding antidepressants and clinical manifestations of DDI. Omeprazole: agomelatine (nausea, abnormal dreams), fluoxetine (extrapyramidal symptoms, paresthesias), sertraline (vertigo, yawning), escitalopram (oral vesiculation). Diphenhydramine: sertraline (diaphoresis, insomnia, vertigo), paroxetine (pruritus, headache), duloxetine (oropharyngeal pain). Japanese ginkgo biloba: citalopram (bradycardia), trazodone (vertigo, taste pervesion), mianserine (restless legs syndrome). Diclofenac: escitalopram (oral vesiculation), and fluoxetine (restless legs syndrome). Ibuprofen: agomelatine (anxiety and nausea), sertraline and omeprazole (QTc prolongation). Sildenafil: fluoxetine (genital oedema) and sertraline (myocardial infarction).Conclusion: The use of OTC drugs by the patients should be monitored. Pharmacokinetic interactions between nonprescribed medicines and antidepressants may increase concentration and severity of side effects of latter ones. |
| first_indexed | 2024-04-11T21:23:19Z |
| format | Article |
| id | doaj.art-bd7367c80dda4a27b769dd0c08a8cfec |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-11T21:23:19Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-bd7367c80dda4a27b769dd0c08a8cfec2022-12-22T04:02:31ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-08-011310.3389/fphar.2022.965432965432Unprescribed and unnoticed: Retrospective chart review of adverse events of interactions between antidepressants and over-the-counter drugsJarosław Woroń0Jarosław Woroń1Jarosław Woroń2Adrian Andrzej Chrobak3Daniel Ślęzak4Marcin Siwek5Department of Clinical Pharmacology, Chair of Pharmacology, Faculty of Medicine, Jagiellonian University Medical College, Kraków, PolandDepartment of Anesthesiology and Intensive Care No. 1, Department of Internal Medicine and Geriatrics, University Hospital in Cracow, Kraków, PolandUniversity Center for Monitoring and Research on Adverse Drug Effects in Krakow, Kraków, PolandDepartment of Adult Psychiatry, Chair of Psychiatry, Jagiellonian University Medical College, Kraków, PolandDivision of Medical Rescue, Faculty of Health Sciences with the Institute of Maritime and Tropical Medicine, Medical University of Gdańsk, Gdańsk, PolandDepartment of Affective Disorders, Chair of Psychiatry, Jagiellonian University Medical College, Kraków, PolandAim: To systematically evaluate prevalence and clinical characteristics of adverse effects of antidepressants and OTC drugs interactions in a retrospective chart review.Methodology: Dataset of 1,145 registered adverse events were evaluated. Reports were selected for further analysis if pharmacoepidemiological avaluation indicated the presence of high probability of a causal relationship between antidepressants and OTC interaction and the occurrence of side effect. Following variables were extracted from the records: sex, age, medical comorbidities, antidepressant and other concomitant medications, clinical consequences ant the possible interaction mechanisms.Results: 368 showed causal relationship with the simultaneous use of antidepressant with another drug. 15 adverse events (4%) were related to the use of OTC medicine, particularly omeprazole, diphenhydramine, Japanese ginkgo biloba, ibuprofen, diclofenac and sildenafil. All of the analysed side effects were categorized as the result of pharmacokinetic interactions. Here we report identified OTC drugs with corresponding antidepressants and clinical manifestations of DDI. Omeprazole: agomelatine (nausea, abnormal dreams), fluoxetine (extrapyramidal symptoms, paresthesias), sertraline (vertigo, yawning), escitalopram (oral vesiculation). Diphenhydramine: sertraline (diaphoresis, insomnia, vertigo), paroxetine (pruritus, headache), duloxetine (oropharyngeal pain). Japanese ginkgo biloba: citalopram (bradycardia), trazodone (vertigo, taste pervesion), mianserine (restless legs syndrome). Diclofenac: escitalopram (oral vesiculation), and fluoxetine (restless legs syndrome). Ibuprofen: agomelatine (anxiety and nausea), sertraline and omeprazole (QTc prolongation). Sildenafil: fluoxetine (genital oedema) and sertraline (myocardial infarction).Conclusion: The use of OTC drugs by the patients should be monitored. Pharmacokinetic interactions between nonprescribed medicines and antidepressants may increase concentration and severity of side effects of latter ones.https://www.frontiersin.org/articles/10.3389/fphar.2022.965432/fullantidepressantsdrug-drug interactionsover-the-counter drugsadverse effectsdepression |
| spellingShingle | Jarosław Woroń Jarosław Woroń Jarosław Woroń Adrian Andrzej Chrobak Daniel Ślęzak Marcin Siwek Unprescribed and unnoticed: Retrospective chart review of adverse events of interactions between antidepressants and over-the-counter drugs Frontiers in Pharmacology antidepressants drug-drug interactions over-the-counter drugs adverse effects depression |
| title | Unprescribed and unnoticed: Retrospective chart review of adverse events of interactions between antidepressants and over-the-counter drugs |
| title_full | Unprescribed and unnoticed: Retrospective chart review of adverse events of interactions between antidepressants and over-the-counter drugs |
| title_fullStr | Unprescribed and unnoticed: Retrospective chart review of adverse events of interactions between antidepressants and over-the-counter drugs |
| title_full_unstemmed | Unprescribed and unnoticed: Retrospective chart review of adverse events of interactions between antidepressants and over-the-counter drugs |
| title_short | Unprescribed and unnoticed: Retrospective chart review of adverse events of interactions between antidepressants and over-the-counter drugs |
| title_sort | unprescribed and unnoticed retrospective chart review of adverse events of interactions between antidepressants and over the counter drugs |
| topic | antidepressants drug-drug interactions over-the-counter drugs adverse effects depression |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.965432/full |
| work_keys_str_mv | AT jarosławworon unprescribedandunnoticedretrospectivechartreviewofadverseeventsofinteractionsbetweenantidepressantsandoverthecounterdrugs AT jarosławworon unprescribedandunnoticedretrospectivechartreviewofadverseeventsofinteractionsbetweenantidepressantsandoverthecounterdrugs AT jarosławworon unprescribedandunnoticedretrospectivechartreviewofadverseeventsofinteractionsbetweenantidepressantsandoverthecounterdrugs AT adrianandrzejchrobak unprescribedandunnoticedretrospectivechartreviewofadverseeventsofinteractionsbetweenantidepressantsandoverthecounterdrugs AT danielslezak unprescribedandunnoticedretrospectivechartreviewofadverseeventsofinteractionsbetweenantidepressantsandoverthecounterdrugs AT marcinsiwek unprescribedandunnoticedretrospectivechartreviewofadverseeventsofinteractionsbetweenantidepressantsandoverthecounterdrugs |