High Antiparasitic and Antimicrobial Performance of Biosynthesized NiO Nanoparticles via Wasted Olive Leaf Extract
Samia Q Alghamdi,1 NF Alotaibi,2 Sameera N Al-Ghamdi,3 Laila S Alqarni,4 Touseef Amna,1 Shaima MN Moustafa,5 Ibrahim Hotan Alsohaimi,2 IA Alruwaili,2 AM Nassar2 1Department of Biology, Faculty of Science, Al-Baha University, Al-Baha, 65799 Saudi Arabia; 2Chemistry Department, College of Science, Jou...
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| Format: | Article |
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Dove Medical Press
2024-02-01
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| Series: | International Journal of Nanomedicine |
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| Online Access: | https://www.dovepress.com/high-antiparasitic-and-antimicrobial-performance-of-biosynthesized-nio-peer-reviewed-fulltext-article-IJN |
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| author | Alghamdi SQ Alotaibi NF Al-Ghamdi SN Alqarni LS Amna T Moustafa SMN Alsohaimi IH Alruwaili IA Nassar AM |
| author_facet | Alghamdi SQ Alotaibi NF Al-Ghamdi SN Alqarni LS Amna T Moustafa SMN Alsohaimi IH Alruwaili IA Nassar AM |
| author_sort | Alghamdi SQ |
| collection | DOAJ |
| description | Samia Q Alghamdi,1 NF Alotaibi,2 Sameera N Al-Ghamdi,3 Laila S Alqarni,4 Touseef Amna,1 Shaima MN Moustafa,5 Ibrahim Hotan Alsohaimi,2 IA Alruwaili,2 AM Nassar2 1Department of Biology, Faculty of Science, Al-Baha University, Al-Baha, 65799 Saudi Arabia; 2Chemistry Department, College of Science, Jouf University, Sakaka, Saudi Arabia; 3Chemistry Department, Faculty of Science, Al-Baha University, Al-Baha, Saudi Arabia; 4Chemistry Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11623 Saudi Arabia; 5Biology Department, College of Science, Jouf University, Sakaka, Saudi ArabiaCorrespondence: AM Nassar, Jouf University, Sakaka, Aljouf, 2014, Saudi Arabia, Tel +966555978016, Email amnassar@ju.edu.saBackground: Nowadays, recycling agricultural waste is of the utmost importance in the world for the production of valuable bioactive compounds and environmental protection. Olive leaf bioactive compounds have a significant potential impact on the pharmaceutical industry. These compounds possess remarkable biological characteristics, including antimicrobial, antiviral, anti-inflammatory, hypoglycemic, and antioxidant properties.Methods: The present study demonstrates a green synthetic approach for the fabrication of nickel oxide nanoparticles (NiO-olive) using aqueous wasted olive leaf extract. Calcination of NiO-olive at 500°C led to the fabrication of pure NiO nanoparticles (NiO-pure). Different techniques, such as thermal gravimetric analysis (TGA), Fourier-transform infrared spectra (FTIR), ultraviolet-visible spectra (UV-Vis), X-ray diffraction (XRD), scanning electron microscopy (SEM) fitted with energy-dispersive X-ray analysis (EDX), and transmission electron microscopy (TEM), were used to characterize both NiO-olive and NiO-pure. The extract and nanoparticles were assessed for antiparasitic activity against adult ticks (Hyalomma dromedarii) and antimicrobial activity against Bacillus cereus, Pseudomonas aeruginosa, Aspergillus niger, and Candida albicans.Results: From XRD, the crystal sizes of NiO-olive and NiO-pure were 32.94 nm and 13.85 nm, respectively. TGA, FTIR, and EDX showed the presence of olive organic residues in NiO-olive and their absence in NiO-pure. SEM and TEM showed an asymmetrical structure of NiO-olive and a regular, semi-spherical structure of NiO-pure. UV–Vis spectra showed surface plasmon resonance of NPs. Antiparasitic activity showed the highest mortality rate of 95% observed at a concentration of 0.06 mg/mL after four days of incubation. The antimicrobial activity showed the largest inhibition zone diameter of 33 ± 0.2 mm against the Candida albicans strain.Conclusion: Nanoparticles of NiO-olive outperformed nanoparticles of NiO-pure and olive leaf extract in both antiparasitic and antimicrobial tests. These findings imply that NiO-olive may be widely used as an eco-friendly and effective antiparasitic and disinfection of sewage.Keywords: biosynthesis, olive, NiO-NP, antiparasitic, antimicrobial] |
| first_indexed | 2024-03-08T00:26:06Z |
| format | Article |
| id | doaj.art-bd7589df6ae24596bafce683ee4ecb46 |
| institution | Directory Open Access Journal |
| issn | 1178-2013 |
| language | English |
| last_indexed | 2024-03-08T00:26:06Z |
| publishDate | 2024-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-bd7589df6ae24596bafce683ee4ecb462024-02-15T19:18:25ZengDove Medical PressInternational Journal of Nanomedicine1178-20132024-02-01Volume 191469148590467High Antiparasitic and Antimicrobial Performance of Biosynthesized NiO Nanoparticles via Wasted Olive Leaf ExtractAlghamdi SQAlotaibi NFAl-Ghamdi SNAlqarni LSAmna TMoustafa SMNAlsohaimi IHAlruwaili IANassar AMSamia Q Alghamdi,1 NF Alotaibi,2 Sameera N Al-Ghamdi,3 Laila S Alqarni,4 Touseef Amna,1 Shaima MN Moustafa,5 Ibrahim Hotan Alsohaimi,2 IA Alruwaili,2 AM Nassar2 1Department of Biology, Faculty of Science, Al-Baha University, Al-Baha, 65799 Saudi Arabia; 2Chemistry Department, College of Science, Jouf University, Sakaka, Saudi Arabia; 3Chemistry Department, Faculty of Science, Al-Baha University, Al-Baha, Saudi Arabia; 4Chemistry Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11623 Saudi Arabia; 5Biology Department, College of Science, Jouf University, Sakaka, Saudi ArabiaCorrespondence: AM Nassar, Jouf University, Sakaka, Aljouf, 2014, Saudi Arabia, Tel +966555978016, Email amnassar@ju.edu.saBackground: Nowadays, recycling agricultural waste is of the utmost importance in the world for the production of valuable bioactive compounds and environmental protection. Olive leaf bioactive compounds have a significant potential impact on the pharmaceutical industry. These compounds possess remarkable biological characteristics, including antimicrobial, antiviral, anti-inflammatory, hypoglycemic, and antioxidant properties.Methods: The present study demonstrates a green synthetic approach for the fabrication of nickel oxide nanoparticles (NiO-olive) using aqueous wasted olive leaf extract. Calcination of NiO-olive at 500°C led to the fabrication of pure NiO nanoparticles (NiO-pure). Different techniques, such as thermal gravimetric analysis (TGA), Fourier-transform infrared spectra (FTIR), ultraviolet-visible spectra (UV-Vis), X-ray diffraction (XRD), scanning electron microscopy (SEM) fitted with energy-dispersive X-ray analysis (EDX), and transmission electron microscopy (TEM), were used to characterize both NiO-olive and NiO-pure. The extract and nanoparticles were assessed for antiparasitic activity against adult ticks (Hyalomma dromedarii) and antimicrobial activity against Bacillus cereus, Pseudomonas aeruginosa, Aspergillus niger, and Candida albicans.Results: From XRD, the crystal sizes of NiO-olive and NiO-pure were 32.94 nm and 13.85 nm, respectively. TGA, FTIR, and EDX showed the presence of olive organic residues in NiO-olive and their absence in NiO-pure. SEM and TEM showed an asymmetrical structure of NiO-olive and a regular, semi-spherical structure of NiO-pure. UV–Vis spectra showed surface plasmon resonance of NPs. Antiparasitic activity showed the highest mortality rate of 95% observed at a concentration of 0.06 mg/mL after four days of incubation. The antimicrobial activity showed the largest inhibition zone diameter of 33 ± 0.2 mm against the Candida albicans strain.Conclusion: Nanoparticles of NiO-olive outperformed nanoparticles of NiO-pure and olive leaf extract in both antiparasitic and antimicrobial tests. These findings imply that NiO-olive may be widely used as an eco-friendly and effective antiparasitic and disinfection of sewage.Keywords: biosynthesis, olive, NiO-NP, antiparasitic, antimicrobial]https://www.dovepress.com/high-antiparasitic-and-antimicrobial-performance-of-biosynthesized-nio-peer-reviewed-fulltext-article-IJNbiosynthesisolivenio-npantiparasiticantimicrobial |
| spellingShingle | Alghamdi SQ Alotaibi NF Al-Ghamdi SN Alqarni LS Amna T Moustafa SMN Alsohaimi IH Alruwaili IA Nassar AM High Antiparasitic and Antimicrobial Performance of Biosynthesized NiO Nanoparticles via Wasted Olive Leaf Extract International Journal of Nanomedicine biosynthesis olive nio-np antiparasitic antimicrobial |
| title | High Antiparasitic and Antimicrobial Performance of Biosynthesized NiO Nanoparticles via Wasted Olive Leaf Extract |
| title_full | High Antiparasitic and Antimicrobial Performance of Biosynthesized NiO Nanoparticles via Wasted Olive Leaf Extract |
| title_fullStr | High Antiparasitic and Antimicrobial Performance of Biosynthesized NiO Nanoparticles via Wasted Olive Leaf Extract |
| title_full_unstemmed | High Antiparasitic and Antimicrobial Performance of Biosynthesized NiO Nanoparticles via Wasted Olive Leaf Extract |
| title_short | High Antiparasitic and Antimicrobial Performance of Biosynthesized NiO Nanoparticles via Wasted Olive Leaf Extract |
| title_sort | high antiparasitic and antimicrobial performance of biosynthesized nio nanoparticles via wasted olive leaf extract |
| topic | biosynthesis olive nio-np antiparasitic antimicrobial |
| url | https://www.dovepress.com/high-antiparasitic-and-antimicrobial-performance-of-biosynthesized-nio-peer-reviewed-fulltext-article-IJN |
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