FAIM: An Antagonist of Fas-Killing and Beyond
Fas Apoptosis Inhibitory Molecule (FAIM) is an anti-apoptotic protein that is up-regulated in B cell receptor (BCR)-activated B cells and confers upon them resistance to Fas-mediated cell death. <i>Faim</i> has two alternatively spliced isoforms, with the short isoform ubiquitously expre...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/8/6/541 |
| _version_ | 1797716274327846912 |
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| author | Jianxin Huo Shengli Xu Kong-Peng Lam |
| author_facet | Jianxin Huo Shengli Xu Kong-Peng Lam |
| author_sort | Jianxin Huo |
| collection | DOAJ |
| description | Fas Apoptosis Inhibitory Molecule (FAIM) is an anti-apoptotic protein that is up-regulated in B cell receptor (BCR)-activated B cells and confers upon them resistance to Fas-mediated cell death. <i>Faim</i> has two alternatively spliced isoforms, with the short isoform ubiquitously expressed in various tissues and the long isoform mainly found in the nervous tissues. FAIM is evolutionarily conserved but does not share any significant primary sequence homology with any known protein. The function of FAIM has been extensively studied in the past 20 years, with its primary role being ascribed to be anti-apoptotic. In addition, several other functions of FAIM were also discovered in different physiological and pathological conditions, such as cell growth, metabolism, Alzheimer’s disease and tumorigenesis. However, the detailed molecular mechanisms underlying FAIM’s role in these conditions remain unknown. In this review, we summarize comprehensively the functions of FAIM in these different contexts and discuss its potential as a diagnostic, prognostic or therapeutic target. |
| first_indexed | 2024-03-12T08:19:09Z |
| format | Article |
| id | doaj.art-bd79ae0d314146cfae112e0d90947693 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T08:19:09Z |
| publishDate | 2019-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-bd79ae0d314146cfae112e0d909476932023-09-02T18:36:40ZengMDPI AGCells2073-44092019-06-018654110.3390/cells8060541cells8060541FAIM: An Antagonist of Fas-Killing and BeyondJianxin Huo0Shengli Xu1Kong-Peng Lam2Bioprocessing Technology Institute, Agency for Science, Technology and Research, Singapore 138668, SingaporeBioprocessing Technology Institute, Agency for Science, Technology and Research, Singapore 138668, SingaporeBioprocessing Technology Institute, Agency for Science, Technology and Research, Singapore 138668, SingaporeFas Apoptosis Inhibitory Molecule (FAIM) is an anti-apoptotic protein that is up-regulated in B cell receptor (BCR)-activated B cells and confers upon them resistance to Fas-mediated cell death. <i>Faim</i> has two alternatively spliced isoforms, with the short isoform ubiquitously expressed in various tissues and the long isoform mainly found in the nervous tissues. FAIM is evolutionarily conserved but does not share any significant primary sequence homology with any known protein. The function of FAIM has been extensively studied in the past 20 years, with its primary role being ascribed to be anti-apoptotic. In addition, several other functions of FAIM were also discovered in different physiological and pathological conditions, such as cell growth, metabolism, Alzheimer’s disease and tumorigenesis. However, the detailed molecular mechanisms underlying FAIM’s role in these conditions remain unknown. In this review, we summarize comprehensively the functions of FAIM in these different contexts and discuss its potential as a diagnostic, prognostic or therapeutic target.https://www.mdpi.com/2073-4409/8/6/541FAIMB cellsFas-mediated apoptosisTCR-mediated apoptosismetabolismAlzheimer’s diseaseMultiple myelomaAktc-FLIP |
| spellingShingle | Jianxin Huo Shengli Xu Kong-Peng Lam FAIM: An Antagonist of Fas-Killing and Beyond Cells FAIM B cells Fas-mediated apoptosis TCR-mediated apoptosis metabolism Alzheimer’s disease Multiple myeloma Akt c-FLIP |
| title | FAIM: An Antagonist of Fas-Killing and Beyond |
| title_full | FAIM: An Antagonist of Fas-Killing and Beyond |
| title_fullStr | FAIM: An Antagonist of Fas-Killing and Beyond |
| title_full_unstemmed | FAIM: An Antagonist of Fas-Killing and Beyond |
| title_short | FAIM: An Antagonist of Fas-Killing and Beyond |
| title_sort | faim an antagonist of fas killing and beyond |
| topic | FAIM B cells Fas-mediated apoptosis TCR-mediated apoptosis metabolism Alzheimer’s disease Multiple myeloma Akt c-FLIP |
| url | https://www.mdpi.com/2073-4409/8/6/541 |
| work_keys_str_mv | AT jianxinhuo faimanantagonistoffaskillingandbeyond AT shenglixu faimanantagonistoffaskillingandbeyond AT kongpenglam faimanantagonistoffaskillingandbeyond |