Differential Antihypertensive Effects of Oral Doses of Acetylcholine between Spontaneously Hypertensive Rats and Normotensive Rats
Acetylcholine (ACh) is a novel antihypertensive food component. Here, we demonstrate the differential effects of oral ACh on high and normal blood pressure in rats. Spontaneously hypertensive rats (SHRs) and Wistar–Kyoto (WKY) rats were administered ACh orally. The blood pressure and heart rate of S...
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MDPI AG
2021-09-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/10/9/2107 |
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| author | Shohei Yamaguchi Kento Matsumoto Wenhao Wang Kozo Nakamura |
| author_facet | Shohei Yamaguchi Kento Matsumoto Wenhao Wang Kozo Nakamura |
| author_sort | Shohei Yamaguchi |
| collection | DOAJ |
| description | Acetylcholine (ACh) is a novel antihypertensive food component. Here, we demonstrate the differential effects of oral ACh on high and normal blood pressure in rats. Spontaneously hypertensive rats (SHRs) and Wistar–Kyoto (WKY) rats were administered ACh orally. The blood pressure and heart rate of SHRs were significantly lowered with ACh doses of 10<sup>−5</sup> and 10<sup>−3</sup> mol/kg body weight (b.w.), and the urinary catecholamine levels were significantly decreased with 10<sup>−3</sup> mol/kg b.w. In contrast, oral ACh administration had no effect on WKY rats. This difference was likely caused by differences in sympathetic nervous activity and the baroreflex between strains. Comparison of gene sequences between the two strains revealed <i>Chga</i> mutations, suggesting that changes in the expression of chromogranin A might be involved in the baroreflex in SHRs. Oral ACh had an antihypertensive effect under hypertension but not normotension, indicating that this may be used safely to prevent hypertension. |
| first_indexed | 2024-03-10T07:40:57Z |
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| id | doaj.art-bd7a9083f9ec48cbacc0c7742595bcbb |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-10T07:40:57Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
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| series | Foods |
| spelling | doaj.art-bd7a9083f9ec48cbacc0c7742595bcbb2023-11-22T13:04:19ZengMDPI AGFoods2304-81582021-09-01109210710.3390/foods10092107Differential Antihypertensive Effects of Oral Doses of Acetylcholine between Spontaneously Hypertensive Rats and Normotensive RatsShohei Yamaguchi0Kento Matsumoto1Wenhao Wang2Kozo Nakamura3Department of Science and Technology, Graduate School of Medicine, Science and Technology, Shinshu University, 8304, Minamiminowa, Nagano 399-4598, JapanItoen Co., Ltd., 21, Mekami, Makinohara, Shizuoka 421-0516, JapanDepartment of Science and Technology, Graduate School of Medicine, Science and Technology, Shinshu University, 8304, Minamiminowa, Nagano 399-4598, JapanDepartment of Science and Technology, Graduate School of Medicine, Science and Technology, Shinshu University, 8304, Minamiminowa, Nagano 399-4598, JapanAcetylcholine (ACh) is a novel antihypertensive food component. Here, we demonstrate the differential effects of oral ACh on high and normal blood pressure in rats. Spontaneously hypertensive rats (SHRs) and Wistar–Kyoto (WKY) rats were administered ACh orally. The blood pressure and heart rate of SHRs were significantly lowered with ACh doses of 10<sup>−5</sup> and 10<sup>−3</sup> mol/kg body weight (b.w.), and the urinary catecholamine levels were significantly decreased with 10<sup>−3</sup> mol/kg b.w. In contrast, oral ACh administration had no effect on WKY rats. This difference was likely caused by differences in sympathetic nervous activity and the baroreflex between strains. Comparison of gene sequences between the two strains revealed <i>Chga</i> mutations, suggesting that changes in the expression of chromogranin A might be involved in the baroreflex in SHRs. Oral ACh had an antihypertensive effect under hypertension but not normotension, indicating that this may be used safely to prevent hypertension.https://www.mdpi.com/2304-8158/10/9/2107acetylcholineblood pressurefunctional foodspontaneously hypertensive ratsWistar–Kyoto rats |
| spellingShingle | Shohei Yamaguchi Kento Matsumoto Wenhao Wang Kozo Nakamura Differential Antihypertensive Effects of Oral Doses of Acetylcholine between Spontaneously Hypertensive Rats and Normotensive Rats Foods acetylcholine blood pressure functional food spontaneously hypertensive rats Wistar–Kyoto rats |
| title | Differential Antihypertensive Effects of Oral Doses of Acetylcholine between Spontaneously Hypertensive Rats and Normotensive Rats |
| title_full | Differential Antihypertensive Effects of Oral Doses of Acetylcholine between Spontaneously Hypertensive Rats and Normotensive Rats |
| title_fullStr | Differential Antihypertensive Effects of Oral Doses of Acetylcholine between Spontaneously Hypertensive Rats and Normotensive Rats |
| title_full_unstemmed | Differential Antihypertensive Effects of Oral Doses of Acetylcholine between Spontaneously Hypertensive Rats and Normotensive Rats |
| title_short | Differential Antihypertensive Effects of Oral Doses of Acetylcholine between Spontaneously Hypertensive Rats and Normotensive Rats |
| title_sort | differential antihypertensive effects of oral doses of acetylcholine between spontaneously hypertensive rats and normotensive rats |
| topic | acetylcholine blood pressure functional food spontaneously hypertensive rats Wistar–Kyoto rats |
| url | https://www.mdpi.com/2304-8158/10/9/2107 |
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