Molecular biomarkers in multiple sclerosis
Abstract Multiple sclerosis (MS) is an inflammatory-neurodegenerative disease of the central nervous system presenting with significant inter- and intraindividual heterogeneity. However, the application of clinical and imaging biomarkers is currently not able to allow individual characterization and...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-12-01
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| Series: | Journal of Neuroinflammation |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12974-019-1674-2 |
| _version_ | 1818622759127744512 |
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| author | Tjalf Ziemssen Katja Akgün Wolfgang Brück |
| author_facet | Tjalf Ziemssen Katja Akgün Wolfgang Brück |
| author_sort | Tjalf Ziemssen |
| collection | DOAJ |
| description | Abstract Multiple sclerosis (MS) is an inflammatory-neurodegenerative disease of the central nervous system presenting with significant inter- and intraindividual heterogeneity. However, the application of clinical and imaging biomarkers is currently not able to allow individual characterization and prediction. Complementary, molecular biomarkers which are easily quantifiable come from the areas of immunology and neurobiology due to the causal pathomechanisms and can excellently complement other disease characteristics. Only a few molecular biomarkers have so far been routinely used in clinical practice as their validation and transfer take a long time. This review describes the characteristics that an ideal MS biomarker should have and the challenges of establishing new biomarkers. In addition, clinically relevant and promising biomarkers from the blood and cerebrospinal fluid are presented which are useful for MS diagnosis and prognosis as well as for the assessment of therapy response and side effects. |
| first_indexed | 2024-12-16T18:30:16Z |
| format | Article |
| id | doaj.art-bd7d34bf98db4562bb32589f3fa45762 |
| institution | Directory Open Access Journal |
| issn | 1742-2094 |
| language | English |
| last_indexed | 2024-12-16T18:30:16Z |
| publishDate | 2019-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Neuroinflammation |
| spelling | doaj.art-bd7d34bf98db4562bb32589f3fa457622022-12-21T22:21:19ZengBMCJournal of Neuroinflammation1742-20942019-12-0116111110.1186/s12974-019-1674-2Molecular biomarkers in multiple sclerosisTjalf Ziemssen0Katja Akgün1Wolfgang Brück2MS center, Center of Clinical Neuroscience, University Clinic Carl-Gustav Carus, Dresden University of TechnologyMS center, Center of Clinical Neuroscience, University Clinic Carl-Gustav Carus, Dresden University of TechnologyInstitute of Neuropathology, University Medical CenterAbstract Multiple sclerosis (MS) is an inflammatory-neurodegenerative disease of the central nervous system presenting with significant inter- and intraindividual heterogeneity. However, the application of clinical and imaging biomarkers is currently not able to allow individual characterization and prediction. Complementary, molecular biomarkers which are easily quantifiable come from the areas of immunology and neurobiology due to the causal pathomechanisms and can excellently complement other disease characteristics. Only a few molecular biomarkers have so far been routinely used in clinical practice as their validation and transfer take a long time. This review describes the characteristics that an ideal MS biomarker should have and the challenges of establishing new biomarkers. In addition, clinically relevant and promising biomarkers from the blood and cerebrospinal fluid are presented which are useful for MS diagnosis and prognosis as well as for the assessment of therapy response and side effects.https://doi.org/10.1186/s12974-019-1674-2Multiple sclerosisMolecular biomarkerOligoclonal bandsNeurofilamentCerebrospinal fluidTreatment response |
| spellingShingle | Tjalf Ziemssen Katja Akgün Wolfgang Brück Molecular biomarkers in multiple sclerosis Journal of Neuroinflammation Multiple sclerosis Molecular biomarker Oligoclonal bands Neurofilament Cerebrospinal fluid Treatment response |
| title | Molecular biomarkers in multiple sclerosis |
| title_full | Molecular biomarkers in multiple sclerosis |
| title_fullStr | Molecular biomarkers in multiple sclerosis |
| title_full_unstemmed | Molecular biomarkers in multiple sclerosis |
| title_short | Molecular biomarkers in multiple sclerosis |
| title_sort | molecular biomarkers in multiple sclerosis |
| topic | Multiple sclerosis Molecular biomarker Oligoclonal bands Neurofilament Cerebrospinal fluid Treatment response |
| url | https://doi.org/10.1186/s12974-019-1674-2 |
| work_keys_str_mv | AT tjalfziemssen molecularbiomarkersinmultiplesclerosis AT katjaakgun molecularbiomarkersinmultiplesclerosis AT wolfgangbruck molecularbiomarkersinmultiplesclerosis |