Adjuvant Effect of Orally Applied Preparations Containing Non-Digestible Polysaccharides on Influenza Vaccination in Healthy Seniors: A Double-Blind, Randomised, Controlled Pilot Trial
Senior individuals can suffer from immunosenescence and novel strategies to bolster the immune response could contribute to healthy ageing. In this double-blind, randomised, controlled pilot trial, we investigated the ability of non-digestible polysaccharide (NPS) preparations to enhance the immune...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/8/2683 |
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| author | Christiane Laue Yala Stevens Monique van Erp Ekaterina Papazova Edlyn Soeth Angelika Pannenbeckers Ellen Stolte Ruwen Böhm Sophie Le Gall Xavier Falourd Simon Ballance Svein H. Knutsen Iris Pinheiro Sam Possemiers Paul M. Ryan R. Paul Ross Catherine Stanton Jerry M. Wells Sylvie van der Werf Jurriaan J. Mes Juergen Schrezenmeir |
| author_facet | Christiane Laue Yala Stevens Monique van Erp Ekaterina Papazova Edlyn Soeth Angelika Pannenbeckers Ellen Stolte Ruwen Böhm Sophie Le Gall Xavier Falourd Simon Ballance Svein H. Knutsen Iris Pinheiro Sam Possemiers Paul M. Ryan R. Paul Ross Catherine Stanton Jerry M. Wells Sylvie van der Werf Jurriaan J. Mes Juergen Schrezenmeir |
| author_sort | Christiane Laue |
| collection | DOAJ |
| description | Senior individuals can suffer from immunosenescence and novel strategies to bolster the immune response could contribute to healthy ageing. In this double-blind, randomised, controlled pilot trial, we investigated the ability of non-digestible polysaccharide (NPS) preparations to enhance the immune response in a human vaccination model. In total, 239 subjects (aged 50–79 years) were randomised to consume one of five different NPS (yeast β-glucan (YBG), shiitake β-glucan (SBG), oat β-glucan (OBG), arabinoxylan (AX), bacterial exopolysaccharide (EPS)) or control (CTRL) product daily for five weeks. After two weeks of intervention, subjects were vaccinated with seasonal influenza vaccine. The post-vaccination increases in haemagglutination inhibition antibody titres and seroprotection rate against the influenza strains were non-significantly enhanced in the NPS intervention groups compared to CTRL. Specifically, a trend towards a higher mean log<sub>2</sub> fold increase was observed in the AX group (uncorrected <i>p</i> = 0.074) combined with a trend for an increased seroprotection rate, AX group (48.7%) compared to CTRL (25.6%) (uncorrected <i>p</i> = 0.057), for the influenza A H1N1 strain. Subjects consuming AX also had a reduced incidence of common colds compared to CTRL (1 vs. 8; <i>p</i> = 0.029 in Fisher exact test). No adverse effects of NPS consumption were reported. The findings of this pilot study warrant further research to study AX as an oral adjuvant to support vaccine efficacy. |
| first_indexed | 2024-03-10T08:31:31Z |
| format | Article |
| id | doaj.art-bd7e6d341c80497aa3687374c57c0af3 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T08:31:31Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-bd7e6d341c80497aa3687374c57c0af32023-11-22T09:04:30ZengMDPI AGNutrients2072-66432021-08-01138268310.3390/nu13082683Adjuvant Effect of Orally Applied Preparations Containing Non-Digestible Polysaccharides on Influenza Vaccination in Healthy Seniors: A Double-Blind, Randomised, Controlled Pilot TrialChristiane Laue0Yala Stevens1Monique van Erp2Ekaterina Papazova3Edlyn Soeth4Angelika Pannenbeckers5Ellen Stolte6Ruwen Böhm7Sophie Le Gall8Xavier Falourd9Simon Ballance10Svein H. Knutsen11Iris Pinheiro12Sam Possemiers13Paul M. Ryan14R. Paul Ross15Catherine Stanton16Jerry M. Wells17Sylvie van der Werf18Jurriaan J. Mes19Juergen Schrezenmeir20Clinical Research Center Kiel, Kiel Center of Innovation and Technology, 24118 Kiel, GermanyBioActor, Brightlands Health Campus, 6229 GS Maastricht, The NetherlandsBioActor, Brightlands Health Campus, 6229 GS Maastricht, The NetherlandsClinical Research Center Kiel, Kiel Center of Innovation and Technology, 24118 Kiel, GermanyClinical Research Center Kiel, Kiel Center of Innovation and Technology, 24118 Kiel, GermanyClinical Research Center Kiel, Kiel Center of Innovation and Technology, 24118 Kiel, GermanyHost-Microbe Interactomics, Wageningen University & Research, 6708 WD Wageningen, The NetherlandsClinical Research Center Kiel, Kiel Center of Innovation and Technology, 24118 Kiel, GermanyUR1268 BIA, INRA, 44316 Nantes, FranceUR1268 BIA, INRA, 44316 Nantes, FranceNofima, Norwegian Institute of Food Fisheries & Aquaculture Research , 1433 Ås, NorwayNofima, Norwegian Institute of Food Fisheries & Aquaculture Research , 1433 Ås, NorwayProdigest, Technologiepark-Zwijnaarde, 9052 Ghent, BelgiumProdigest, Technologiepark-Zwijnaarde, 9052 Ghent, BelgiumTeagasc, Food Research Centre, Moorepark, Fermoy, Co., P61 C996 Cork, IrelandAPC Microbiome Ireland, University College Cork, T12 YT20 Cork, IrelandTeagasc, Food Research Centre, Moorepark, Fermoy, Co., P61 C996 Cork, IrelandHost-Microbe Interactomics, Wageningen University & Research, 6708 WD Wageningen, The NetherlandsInstitut Pasteur, 75015 Paris, FranceWageningen Food and Biobased Research, Wageningen University & Research, 6708 WG Wageningen, The NetherlandsClinical Research Center Kiel, Kiel Center of Innovation and Technology, 24118 Kiel, GermanySenior individuals can suffer from immunosenescence and novel strategies to bolster the immune response could contribute to healthy ageing. In this double-blind, randomised, controlled pilot trial, we investigated the ability of non-digestible polysaccharide (NPS) preparations to enhance the immune response in a human vaccination model. In total, 239 subjects (aged 50–79 years) were randomised to consume one of five different NPS (yeast β-glucan (YBG), shiitake β-glucan (SBG), oat β-glucan (OBG), arabinoxylan (AX), bacterial exopolysaccharide (EPS)) or control (CTRL) product daily for five weeks. After two weeks of intervention, subjects were vaccinated with seasonal influenza vaccine. The post-vaccination increases in haemagglutination inhibition antibody titres and seroprotection rate against the influenza strains were non-significantly enhanced in the NPS intervention groups compared to CTRL. Specifically, a trend towards a higher mean log<sub>2</sub> fold increase was observed in the AX group (uncorrected <i>p</i> = 0.074) combined with a trend for an increased seroprotection rate, AX group (48.7%) compared to CTRL (25.6%) (uncorrected <i>p</i> = 0.057), for the influenza A H1N1 strain. Subjects consuming AX also had a reduced incidence of common colds compared to CTRL (1 vs. 8; <i>p</i> = 0.029 in Fisher exact test). No adverse effects of NPS consumption were reported. The findings of this pilot study warrant further research to study AX as an oral adjuvant to support vaccine efficacy.https://www.mdpi.com/2072-6643/13/8/2683adjuvantimmunitynon-digestible polysaccharideprebioticsarabinoxylanβ-glucan |
| spellingShingle | Christiane Laue Yala Stevens Monique van Erp Ekaterina Papazova Edlyn Soeth Angelika Pannenbeckers Ellen Stolte Ruwen Böhm Sophie Le Gall Xavier Falourd Simon Ballance Svein H. Knutsen Iris Pinheiro Sam Possemiers Paul M. Ryan R. Paul Ross Catherine Stanton Jerry M. Wells Sylvie van der Werf Jurriaan J. Mes Juergen Schrezenmeir Adjuvant Effect of Orally Applied Preparations Containing Non-Digestible Polysaccharides on Influenza Vaccination in Healthy Seniors: A Double-Blind, Randomised, Controlled Pilot Trial Nutrients adjuvant immunity non-digestible polysaccharide prebiotics arabinoxylan β-glucan |
| title | Adjuvant Effect of Orally Applied Preparations Containing Non-Digestible Polysaccharides on Influenza Vaccination in Healthy Seniors: A Double-Blind, Randomised, Controlled Pilot Trial |
| title_full | Adjuvant Effect of Orally Applied Preparations Containing Non-Digestible Polysaccharides on Influenza Vaccination in Healthy Seniors: A Double-Blind, Randomised, Controlled Pilot Trial |
| title_fullStr | Adjuvant Effect of Orally Applied Preparations Containing Non-Digestible Polysaccharides on Influenza Vaccination in Healthy Seniors: A Double-Blind, Randomised, Controlled Pilot Trial |
| title_full_unstemmed | Adjuvant Effect of Orally Applied Preparations Containing Non-Digestible Polysaccharides on Influenza Vaccination in Healthy Seniors: A Double-Blind, Randomised, Controlled Pilot Trial |
| title_short | Adjuvant Effect of Orally Applied Preparations Containing Non-Digestible Polysaccharides on Influenza Vaccination in Healthy Seniors: A Double-Blind, Randomised, Controlled Pilot Trial |
| title_sort | adjuvant effect of orally applied preparations containing non digestible polysaccharides on influenza vaccination in healthy seniors a double blind randomised controlled pilot trial |
| topic | adjuvant immunity non-digestible polysaccharide prebiotics arabinoxylan β-glucan |
| url | https://www.mdpi.com/2072-6643/13/8/2683 |
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