Ugi Reaction on α-Phosphorated Ketimines for the Synthesis of Tetrasubstituted α-Aminophosphonates and Their Applications as Antiproliferative Agents

Ugi Reaction on α-Phosphorated Ketimines for the Synthesis of Tetrasubstituted α-Aminophosphonates and Their Applications as Antiproliferative Agents

An Ugi three-component reaction using preformed α-phosphorated <i>N</i>-tosyl ketimines with different isocyanides in the presence of a carboxylic acid affords tetrasubstituted α-aminophosphonates. Due to the high steric hindrance, the expected acylated amines undergo a spontaneous elimi...

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Bibliographic Details
Main Authors: Adrián López-Francés, Xabier del Corte, Edorta Martínez de Marigorta, Francisco Palacios, Javier Vicario
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Molecules
Subjects:
multicomponent synthesis
Ugi reaction
α-aminophosphonates
tetrasubstituted carbons
antiproliferative effect
Online Access:https://www.mdpi.com/1420-3049/26/6/1654

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