Identification and validation of prognostic and immunotherapeutic responses in esophageal squamous carcinoma based on hypoxia phenotype-related genes

Identification and validation of prognostic and immunotherapeutic responses in esophageal squamous carcinoma based on hypoxia phenotype-related genes

The study aimed to investigate the clinical significance of the interaction between hypoxia and the immune system in esophageal squamous cell carcinoma (ESCC) microenvironment. A comprehensive evaluation of 13 hypoxia phenotype-related genes (HPRs) was conducted using data from TCGA-ESCC and two GEO...

Full description

Bibliographic Details
Main Authors:	Kai Xie, Zhe Chen, Jian Feng, Liangbin Pan, Nan Wang, Jing Luo, Yu Yao, Haitao Ma, Yu Feng, Wei Jiang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-03-01
Series:	Frontiers in Pharmacology
Subjects:	esophageal squamous cell carcinoma hypoxia tumor microenvironment immunotherapy Prognosis PKP1
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1344317/full

Similar Items

Analysis of immunotherapeutic response-related signatures in esophageal squamous-cell carcinoma
by: Bohao Zheng, et al.
Published: (2023-02-01)

Heparanase is a prognostic biomarker independent of tumor purity and hypoxia based on bioinformatics and immunohistochemistry analysis of esophageal squamous cell carcinoma
by: Yu Wang, et al.
Published: (2022-07-01)

Establishment of a risk model by integrating hypoxia genes in predicting prognosis of esophageal squamous cell carcinoma
by: Wanyi Xiao, et al.
Published: (2023-01-01)

Ferroptosis patterns and tumor microenvironment infiltration characterization in esophageal squamous cell cancer
by: Lu-Lu Zhang, et al.
Published: (2022-12-01)

A fibroblast-associated signature predicts prognosis and immunotherapy in esophageal squamous cell cancer
by: Qianhe Ren, et al.
Published: (2023-05-01)

Phenotypic profiling and prognostic significance of immune infiltrates in esophageal squamous cell carcinoma
by: Chuqing Pan, et al.
Published: (2021-01-01)

Distinct immune signatures for predicting the immunotherapy efficacy of esophageal squamous cell carcinoma or adenocarcinoma
by: Peng Wu, et al.
Published: (2025-01-01)

A Prognostic Signature Based on Immunogenomic Profiling Offers Guidance for Esophageal Squamous Cell Cancer Treatment
by: Jianyao Gao, et al.
Published: (2021-02-01)

Deciphering the Hypoxia-immune interface in esophageal squamous carcinoma: a prognostic network model
by: Jie Hu, et al.
Published: (2023-12-01)

Immune evasion in esophageal squamous cell cancer: From the perspective of tumor microenvironment
by: Rongyang Li, et al.
Published: (2023-01-01)

Identification of Hypoxia-Related Molecular Classification and Associated Gene Signature in Oral Squamous Cell Carcinoma
by: Chen Li, et al.
Published: (2021-11-01)

Hypoxia induced changes in miRNAs and their target mRNAs in extracellular vesicles of esophageal squamous cancer cells
by: Fangyu Chen, et al.
Published: (2020-03-01)

Research Progress of Predictive Markers for Efficacy of Immune Checkpoint Inhibitors for Esophageal Squamous Cell Carcinoma
by: CHEN Rongshan, et al.
Published: (2022-12-01)

Immunohistochemistry and oxygen saturation endoscopic imaging reveal hypoxia in submucosal invasive esophageal squamous cell carcinoma
by: Nobuhisa Minakata, et al.
Published: (2023-08-01)

Identification of Immune-Cell-Related Prognostic Biomarkers of Esophageal Squamous Cell Carcinoma Based on Tumor Microenvironment
by: Yiyao Cui, et al.
Published: (2021-10-01)

From tumor microenvironment to emerging biomarkers: the reshaping of the esophageal squamous cell carcinoma tumor microenvironment by neoadjuvant chemotherapy combined with immunotherapy
by: Zhengzhou Qiu, et al.
Published: (2024-12-01)

The intratumoral landscape of T cell receptor repertoire in esophageal squamous cell carcinoma
by: Meng Yang, et al.
Published: (2024-11-01)

Identification of the Prognostic Value of Tumor Microenvironment-Related Genes in Esophageal Squamous Cell Carcinoma
by: Donglei Zhang, et al.
Published: (2020-12-01)

Identification of prognostic hypoxia-related genes signature on the tumor microenvironment in esophageal cancer
by: Linlin Tan, et al.
Published: (2021-09-01)

Systematic profiling of ferroptosis gene signatures predicts prognostic factors in esophageal squamous cell carcinoma
by: Tong Lu, et al.
Published: (2021-06-01)

Identification of a Prognostic Gene Signature Based on Lipid Metabolism-Related Genes in Esophageal Squamous Cell Carcinoma
by: Shen GY, et al.
Published: (2023-11-01)

Research Status and Progress on Immunotherapy for Advanced Esophageal Squamous Cell Carcinoma in Hebei Province
by: Xiaoyang DUAN, et al.
Published: (2025-02-01)

Prognostic significance of baseline peripheral blood lymphocyte subsets on second-line immunotherapy in advanced esophageal squamous cell carcinoma
by: Qike Wang, et al.
Published: (2023-08-01)

Pre-immunotherapy radiotherapy enhanced the efficacy of multi-line sintilimab in unresectable advanced esophageal squamous cell carcinoma
by: Shuhui Xu, et al.
Published: (2023-02-01)

Prognostic Value of Lactate Dehydrogenase in Second-Line Immunotherapy for Advanced Esophageal Squamous Cell Carcinoma
by: Yan Li, et al.
Published: (2022-06-01)

SIRT1 overexpression is an independent prognosticator for patients with esophageal squamous cell carcinoma
by: Ming-Chun Ma, et al.
Published: (2018-04-01)

Preoperative pembrolizumab combined with chemoradiotherapy for esophageal squamous cell carcinoma: Trial designCentral MessagePerspective
by: Yuyan Zheng, MD, et al.
Published: (2022-03-01)

Spatial transcriptomic analysis of tumor microenvironment in esophageal squamous cell carcinoma with HIV infection
by: Yuanli Zuo, et al.
Published: (2025-02-01)

Study on the efficacy and safety of neoadjuvant immunotherapy combined with chemotherapy regimen for III–IVA esophageal squamous cell carcinoma post-surgery
by: Chunyang Li, et al.
Published: (2024-01-01)

The value of intervention with radiotherapy after first-line chemo-immunotherapy in locally advanced or metastatic esophageal squamous cell carcinoma: A multi-center retrospective study
by: Hui-Hui Hu, et al.
Published: (2024-09-01)

The Role of Tumor Microenvironment in Invasion and Metastasis of Esophageal Squamous Cell Carcinoma
by: Shuyue Zheng, et al.
Published: (2022-06-01)

Prognostic factors for esophageal respiratory fistula in unresectable esophageal squamous cell carcinoma treated with radiotherapy
by: Jia-Chao Qi, et al.
Published: (2024-07-01)

Patterns and prognostic predictive value of perineural invasion in esophageal squamous cell carcinoma
by: Yu Ma, et al.
Published: (2022-12-01)

Intratumoral microbiome impacts immune infiltrates in tumor microenvironment and predicts prognosis in esophageal squamous cell carcinoma patients
by: Shuyue Zhang, et al.
Published: (2023-04-01)

Neoadjuvant chemoimmunotherapy was associated with better short‐term survival of patients with locally advanced esophageal squamous cell carcinoma compared to neoadjuvant chemoradiotherapy
by: Xiaofeng Duan, et al.
Published: (2024-08-01)

Prognostic significance of Glasgow prognostic score in patients undergoing esophagectomy for esophageal squamous cell carcinoma
by: Ji-Feng Feng, et al.
Published: (2014-01-01)

Eosinophils Exert Antitumorigenic Effects in the Development of Esophageal Squamous Cell CarcinomaSummary
by: Justin Jacobse, et al.
Published: (2023-01-01)

Roles of circRNA dysregulation in esophageal squamous cell carcinoma tumor microenvironment
by: Jingyi Li, et al.
Published: (2023-06-01)

Development and validation of a prognostic model for esophageal carcinoma based on immune microenvironment using system bioinformatics
by: Chenchun Fu, et al.
Published: (2023-01-01)

Comparison of neoadjuvant nab‐paclitaxel plus immunotherapy versus paclitaxel plus immunotherapy for esophageal squamous cell carcinoma
by: Yafan Yang, et al.
Published: (2023-03-01)