Salidroside reduces neuropathology in Alzheimer’s disease models by targeting NRF2/SIRT3 pathway

Salidroside reduces neuropathology in Alzheimer’s disease models by targeting NRF2/SIRT3 pathway

Abstract Background Neurite dystrophy is a pathologic hallmark of Alzheimer’s disease (AD). However, drug discovery targeting neurite protection in AD remains largely unexplored. Methods Aβ-induced neurite and mitochondrial damage assays were used to evaluate Aβ toxicity and the neuroprotective effi...

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Bibliographic Details
Main Authors: Yuyuan Yao, Zhichu Ren, Ruihan Yang, Yilan Mei, Yuying Dai, Qian Cheng, Chong Xu, Xiaogang Xu, Sanying Wang, Kyoung Mi Kim, Ji Heon Noh, Jian Zhu, Ningwei Zhao, Yong U. Liu, Genxiang Mao, Jian Sima
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Cell & Bioscience
Subjects:
Alzheimer’s disease
Mitochondrial protection
SAL
SIRT3
NRF2
Online Access:https://doi.org/10.1186/s13578-022-00918-z

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